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Identification and characterization a novel protein component of the survival of motor neurons complex termed Gemin7 using native purified SMN (show STMN1 ELISA Kits) complexes and peptide sequencing by mass spectrometry
Unrip (show STRAP ELISA Kits) is recruited to the active SMN (show STMN1 ELISA Kits) complex via a stable interaction with Gemin7
Gemin8 (show GEMIN8 ELISA Kits) has an essential role in the proper structural organization of the SMN (show STMN1 ELISA Kits) complex and the involvement of the heteromeric subunit containing Gemin6 (show GEMIN6 ELISA Kits), Gemin7, Gemin8 (show GEMIN8 ELISA Kits), and Unrip (show STRAP ELISA Kits) in the recruitment of Sm proteins to the snRNP (show LSM2 ELISA Kits) assembly pathway
The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear 'gems' (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.
gem (nuclear organelle) associated protein 7
, gem-associated protein 7
, gemin 7