Browse our LIMD1 Proteins (LIMD1)

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LIM Domains Containing 1 Proteins (LIMD1)
On are 6 LIM Domains Containing 1 (LIMD1) Proteins from 4 different suppliers available. Additionally we are shipping LIMD1 Antibodies (79) and many more products for this protein. A total of 87 LIMD1 products are currently listed.
AW822033, D9Ertd192e, LIMD1, xlimd1
list all proteins Gene Name GeneID UniProt
LIMD1 494021  
LIMD1 8994 Q9UGP4
LIMD1 29806 Q9QXD8

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LIMD1 Proteins (LIMD1) by Origin

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More Proteins for LIMD1 Interaction Partners

Human LIM Domains Containing 1 (LIMD1) interaction partners

  1. These results suggested that LIMD1 is a novel BRCA2-interacting protein and is involved in the centrosome localization of BRCA2 (show BRCA2 Proteins) and suppression of LIMD1, causing abnormal cell division in EC cells.

  2. Thus, the LIMD1-MYBL1 (show MYBL1 Proteins) Index had considerable clinical value for DLBCL subtype classification and prognosis.

  3. Cyclic stretch is associated with a JNK (show MAPK8 Proteins)-dependent increase in binding of a LATS inhibitor, LIMD1, to the LATS1 kinase and that reduction of LIMD1 expression suppresses the activation of YAP (show YAP1 Proteins) by cyclic stretch.

  4. LIMD1 prevents retinoblastoma phosphorylation and downregulates of E2F1 (show E2F1 Proteins) protein and blocks entry of cells into S-phase.

  5. Data show that the tumour suppressor protein LIMD1 acts as a molecular scaffold, simultaneously binding the PHDs and VHL (show VHL Proteins), thereby assembling a PHD (show PDC Proteins)-LIMD1-VHL (show VHL Proteins) protein complex and creating an enzymatic niche that enables efficient degradation of HIF-1alpha (show HIF1A Proteins).

  6. PU.1 is a major transcriptional activator of LIMD1

  7. LIMD1 inactivation as primary event than inactivation of RB1 (show RB1 Proteins) in head and neck squamous cell carcinoma development.

  8. LIMD1 is a tumor-suppressor gene, the protein product of which functionally interacts with pRB (show RB1 Proteins) and the loss of which promotes lung carcinogenesis

  9. These results suggest that some breast tumors have altered expression of LIMD1 RNA and that LIMD1 may be involved in cell anchoring via focal adhesions and in the cell cycle, particularly during mitosis.

  10. study demonstrates that LIMD1 represents a novel prognostic marker for breast cancer. Combined with the fact that LIMD1 expression is downregulated in lung cancers this clearly indicates that LIMD1 may represent a critical tumor suppressor gene

Mouse (Murine) LIM Domains Containing 1 (LIMD1) interaction partners

  1. Limd1 regulates AP-1 (show JUN Proteins) activation through an interaction with Traf6 (show TRAF6 Proteins) to influence osteoclast development

  2. Limd1 influences not only stress osteoclastogenesis but also osteoblast function and osteoblast progenitor commitment. Together, these data identify Limd1 as a novel regulator of both bone osetoclast and bone osteoblast development and function.

LIMD1 Protein Profile

Protein Summary

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG- dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1- responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation (By similarity).

Alternative names and synonyms associated with LIMD1

  • LIM domains containing 1 (limd1)
  • LIM and cysteine-rich domains 1 (Lmcd1)
  • LIM domains containing 1 (LIMD1)
  • LIM domains containing 1 (Limd1)
  • AW822033 protein
  • D9Ertd192e protein
  • LIMD1 protein
  • xlimd1 protein

Protein level used designations for LIMD1

LIM domain-containing protein 1 , LIM and cysteine-rich domains protein 1 , dyxin , LIM domains-containing protein 1

549360 Xenopus (Silurana) tropicalis
494021 Rattus norvegicus
779085 Xenopus laevis
8994 Homo sapiens
484796 Canis lupus familiaris
29806 Mus musculus
617525 Bos taurus
316101 Rattus norvegicus
420701 Gallus gallus
100738579 Sus scrofa
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