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The results suggest that RPA phosphorylation enhances the recruitment of PRP19 to RPA-ssDNA and stimulates RPA ubiquitylation through a process requiring both PRP19 and RFWD3, thereby triggering a phosphorylation-ubiquitylation circuitry that promotes ATR activation and homologous recombination.
role of Pso4 in DNA repair and DNA damage
Study demonstrates that the levels of Prp19 and Cdc5L (show CDC5L Proteins) are overexpressed in hepatocellular carcinoma (HCC (show FAM126A Proteins)). Prp19 binds with Cdc5L (show CDC5L Proteins) and its downregulation results in reduction of Cdc5L (show CDC5L Proteins). Mechanistic insights reveal that silencing Prp19 compromises translation activity of Cdc5L (show CDC5L Proteins) and facilitates lysosome-induced degradation of Cdc5L (show CDC5L Proteins) in HCC (show FAM126A Proteins) cells.
We report that PRP19 expression is elevated in lung carcinoma tissues compared to non-tumor tissues
These findings suggest that SKAP promotes ultraviolet rays-induced cell apoptosis by negatively regulating the anti-apoptotic protein Prp19.
involvement of hPso4 in the recombinational repair of DSBs
DNA damage induces down-regulation of Prp19 via impairing Prp19 stability in hepatocellular carcinoma cells.
The Prp19-CDC5L (show CDC5L Proteins) complex plays a crucial role during human pre-mRNA splicing by catalytic activation of the spliceosome.
Prp19 complex as the first spliceosome subcomplex that directly contributes to mitosis in vertebrates independently of its function in interphase.
PRP19 directly binds RPA and localizes to DNA damage sites via RPA, promoting RPA ubiquitylation in a DNA-damage-induced manner.
SNEV(P) (rp19/) (PSO) (4) deficiency increases PUVA-induced senescence in mouse skin
the alpha-variant of Prp19 gene plays a pivotal role in neural differentiation and that the beta-variant participates in neuronal/astroglial cell fate decisions
Down-regulation of Prp19p expression with RNA interference in 3T3-L1 cells repressed lipid droplet formation with the reduction in the level of expression of perilipin (show PLIN1 Proteins) and S3-12 (show PLIN4 Proteins)
SNEV is indispensable for early mouse development; MEFs (mouse embryonic fibroblasts) with reduced SNEV levels have lowered proliferative potential.
Immunofluorescence microscopy revealed that a domain of amino acids 167-250 is necessary for the recruitment of Prp19p to lipid droplets and that a domain of amino acids 1-166 is necessary for the recruitment of Prp19p to a nucleus.
The expression of SNEV is closely associated with the growth of murine hematopoietic stem cells (HSCs) and determines the proliferative and repopulating capacity of phenotypically defined HSC (show FUT1 Proteins) subsets.
The knockdown of PRPF19 or EIF4A3 (show EIF4A3 Proteins) decreased splicing of Lhb (show LHB Proteins), or of both beta subunit (show POLG Proteins) transcripts, respectively.
PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008
pre-mRNA-processing factor 19
, nuclear matrix protein NMP200 related to splicing factor PRP19
, PRP19/PSO4 pre-mRNA processing factor 19 homolog
, PRP19/PSO4 homolog
, nuclear matrix protein 200
, senescence evasion factor
, neuronal differentiation-related gene protein
, pre-mRNA processing factor 19
, nuclear matrix protein SNEV
, prp19 beta