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Human Polyclonal SART3 Primary Antibody for ELISA, WB - ABIN250557
Bell, Schreiner, Damianov, Reddy, Bindereif: p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor. in The EMBO journal 2002
Dog (Canine) Polyclonal SART3 Primary Antibody for IHC, WB - ABIN2780944
Liu, Li, Kim, Pace, He: HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110. in The Journal of biological chemistry 2002
Show all 2 Pubmed References
Cow (Bovine) Polyclonal SART3 Primary Antibody for WB - ABIN2780945
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
We show that PRP31 (show PRPF31 Antibodies), a component of U4 snRNP (show LSM2 Antibodies), is modified with K63-linked ubiquitin chains by the PRP19 (show PRPF19 Antibodies) complex and deubiquitinated by USP15 (show USP15 Antibodies) and its substrate targeting factor SART3. USP15SART3 makes a complex with USP4 (show USP4 Antibodies) and this ternary complex serves as a platform to deubiquitinate PRP31 (show PRPF31 Antibodies) and PRP3 (show CLCA4 Antibodies)
The complex structure of SART3 nuclear localization signal (NLS (show ALDH1A2 Antibodies)) and importin-alpha reveals bipartite binding, and removal of SART3 NLS (show ALDH1A2 Antibodies) prevents the entry of USP4 (show USP4 Antibodies) (and USP15 (show USP15 Antibodies)) into the nucleus and abrogates the subsequent deubiquitinase activity of USP4 (show USP4 Antibodies).
crystal structures of SART3 in the apo (show C9orf3 Antibodies)-form and in complex with the DUSP (show DUSP5 Antibodies)-UBL domain of USP15 (show USP15 Antibodies) at 2.0 and 3.0 A, respectively. Structural analysis reveals SART3 contains 12 half-a-tetratricopeptide (HAT (show MGEA5 Antibodies)) repeats, organized into two subdomains, HAT (show MGEA5 Antibodies)-N and HAT (show MGEA5 Antibodies)-C. SART3 dimerizes through the concave surface of HAT (show MGEA5 Antibodies)-C, whereas the HAT (show MGEA5 Antibodies)-C convex surface binds USP15 (show USP15 Antibodies) in a novel bipartite mode.
miR (show MLXIP Antibodies)-124 regulates Tip110 expression and differentiation of human cord blood CD34 (show CD34 Antibodies)(+) cells
Hypoxia led to Tip110 protein degradation through the ubiquitin-proteasome system. Under hypoxia, Tip110 stabilized p53 (show TP53 Antibodies), which in return destabilized Tip110.
SART3 recruits ubH2B, which may be evicted from DNA during transcription, for deubiquitination by Usp15 (show USP15 Antibodies)
YB-1 (show YBX1 Antibodies) potentiates the Tip110/Tat (show TAT Antibodies)-mediated transactivation of the HIV-1 LTR promoter.
findings show C-MYC (show MYC Antibodies) upregulates transcription of TIP110 through interaction with the TIP110 E-box in the TIP110 promoter, ensuring high-level Tip110 expression in proliferating embryonic stem cells (hESCs); further show TIP110 regulates OCT4 (show POU5F1 Antibodies) alternative splicing in hESCs
TIP110 is also expressed in human embryonic stem cells (hESCs) and expression was decreased with differentiation of these ESCs (show NR2E3 Antibodies).
Results suggest that U4 and U6 small nuclear ribonucleoproteins (snRNPs) accumulate in Cajal bodies for the purpose of assembly into U4/U6 snRNPs by SART3/p110.
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.
squamous cell carcinoma antigen recognized by T cells 3
, Squamous cell carcinoma antigen recognized by T-cells 3
, squamous cell carcinoma antigen recognized by T-cells 3-like
, earl grey
, squamous cell carcinoma antigen recognized by T-cells 3
, tat-interacting protein of 110 kDa
, tumor-rejection antigen SART3