Browse our anti-Shwachman-Bodian-Diamond Syndrome (SBDS) Antibodies

Full name:
anti-Shwachman-Bodian-Diamond Syndrome Antibodies (SBDS)
On www.antibodies-online.com are 48 Shwachman-Bodian-Diamond Syndrome (SBDS) Antibodies from 11 different suppliers available. Additionally we are shipping Shwachman-Bodian-Diamond Syndrome Proteins (17) and Shwachman-Bodian-Diamond Syndrome Kits (5) and many more products for this protein. A total of 74 Shwachman-Bodian-Diamond Syndrome products are currently listed.
Synonyms:
4733401P19Rik, AI836084, CGI-97, SDS, SWDS, zgc:56700

Most Popular Reactivities for anti-Shwachman-Bodian-Diamond Syndrome (SBDS) Antibodies

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Top referenced anti-Shwachman-Bodian-Diamond Syndrome Antibodies

  1. Human Monoclonal SBDS Primary Antibody for EIA, WB - ABIN1449399 : Boocock, Morrison, Popovic, Richards, Ellis, Durie, Rommens: Mutations in SBDS are associated with Shwachman-Diamond syndrome. in Nature genetics 2003 (PubMed)
    Show all 3 references for 1449399

  2. Cow (Bovine) Polyclonal SBDS Primary Antibody for IHC, WB - ABIN2782336 : Austin, Leary, Shimamura: The Shwachman-Diamond SBDS protein localizes to the nucleolus. in Blood 2005 (PubMed)
    Show all 2 references for 2782336

More Antibodies against Shwachman-Bodian-Diamond Syndrome Interaction Partners

Zebrafish Shwachman-Bodian-Diamond Syndrome (SBDS) interaction partners

  1. Knockdown of the zebrafish sbds ortholog fully recapitulates the spectrum of developmental abnormalities observed in the human Shwachman-Bodian-Diamond syndrome.

  2. The sbds gene function is essential for normal pancreas and myeloid development in zebrafish. Zebrafish is a model system to study sbds gene function and for evaluation of novel therapies for Shwachman-Diamond syndrome.

Human Shwachman-Bodian-Diamond Syndrome (SBDS) interaction partners

  1. SBDS function is specifically required for efficient translation re-initiation into the protein isoforms C/EBPalpha (show CEBPA Antibodies)-p30 (show CENPV Antibodies) and C/EBPbeta (show CEBPB Antibodies)-LIP, which is controlled by a single cis (show CISH Antibodies)-regulatory upstream open reading frame (uORF) in the 5' untranslated regions (5' UTRs) of both mRNAs.

  2. Association of EFL1 (show EFNA1 Antibodies) to SBDS did not modify the affinity for GTP (show AK3 Antibodies) but dramatically decreased that for GDP by increasing the dissociation rate of the nucleotide.

  3. The clinical diagnosis was confirmed by detection of compound heterozygous mutations in SBDS using whole-exome sequencing: a recurrent intronic mutation causing aberrant splicing (c.258+2T>C) and a novel missense variant in a highly conserved codon (c.41A>G, p.Asn14Ser), considered to be damaging for the protein structure by in silico prediction programs

  4. Upon EFL1 (show EFNA1 Antibodies) binding, SBDS is repositioned around helix 69, thus facilitating a conformational switch in EFL1 (show EFNA1 Antibodies) that displaces eIF6 (show EIF6 Antibodies) by competing for an overlapping binding site on the 60S ribosomal subunit.

  5. Genetic variations in exon 2 of SBDS gene do not appear to be contributing to aplastic anemia in the north Indian population.

  6. The interaction between EFL1 (show EFNA1 Antibodies) and SBDS was analyzed by size exclusion chromatography, gel shift assay, and isothermal titration calorimetry. The results showed that EFL1 (show EFNA1 Antibodies) interacted directly with SBDS.

  7. SBDS protein acts as a nucleotide exchange factor that stabilizes binding to GTP (show AK3 Antibodies) for human GTPase (show RACGAP1 Antibodies).

  8. Lack of mutation in exon 2 of sbds protein in acute myeloid leukemia (show BCL11A Antibodies) suggests this subset is unlikely to have underlying sds (show SDS Antibodies)

  9. We conclude that knockdown of SBDS leads to growth inhibition and defects in ribosome maturation

  10. SBDS protein facilitates the release of eIF6 (show EIF6 Antibodies), a factor that prevents ribosome joining.

Mouse (Murine) Shwachman-Bodian-Diamond Syndrome (SBDS) interaction partners

  1. Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes

  2. Sbds genotypes correlated with phenotypes in a mouse model of Shwachman-Diamond syndrome. Defects developed specifically in the pancreata of mice, reducing growth of mice and production of digestive enzymes.

  3. Sbds is required for osteoclastogenesis by regulating monocyte migration via Rac2 (show RAC2 Antibodies) and osteoclast differentiation signaling downstream of RANK.

  4. Sbds is an essential gene for early mammalian development, with an expression pattern consistent with a critical role in cell proliferation.

  5. loss of Sbds is sufficient to induce abnormalities in hematopoiesis

  6. The majority of Shwachman-Diamond syndrome cases are results of mutations in SBDS gene on chromosone 7q11.

Shwachman-Bodian-Diamond Syndrome (SBDS) Antigen Profile

Antigen Summary

This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located.

Alternative names and synonyms associated with Shwachman-Bodian-Diamond Syndrome (SBDS)

  • Shwachman-Bodian-Diamond syndrome (sbds) antibody
  • shwachman-Bodian-Diamond syndrome (LOAG_04440) antibody
  • Shwachman-Bodian-Diamond syndrome (SBDS) antibody
  • Shwachman-Bodian-Diamond syndrome (Sbds) antibody
  • Shwachman-Bodian-Diamond syndrome homolog (human) (Sbds) antibody
  • 4733401P19Rik antibody
  • AI836084 antibody
  • CGI-97 antibody
  • SDS antibody
  • SWDS antibody
  • zgc:56700 antibody

Protein level used designations for SBDS

ribosome maturation protein SBDS , shwachman-Bodian-Diamond syndrome protein homolog , shwachman-Bodian-Diamond syndrome , Shwachman-Bodian-Diamond syndrome homolog , protein 22A3

GENE ID SPECIES
448365 Xenopus (Silurana) tropicalis
9941848 Loa loa
394096 Danio rerio
100049749 Xenopus laevis
417477 Gallus gallus
51119 Homo sapiens
607017 Canis lupus familiaris
513237 Bos taurus
288615 Rattus norvegicus
100172536 Pongo abelii
66711 Mus musculus
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