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SF3a60, 66, and 120, but not SF1 (show NR5A1 Proteins), are essential for pre-mRNA splicing
SF3a3 functions as a co-repressor of Constitutive Androstane Receptor (show NR1I3 Proteins) transcriptional activity, in addition to its canonical function.
This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20.
splicing factor 3a, subunit 3, 60kDa
, splicing factor 3A subunit 3-like
, SAP 61
, spliceosome-associated protein 61
, splicing factor 3A subunit 3
, pre-mRNA splicing factor SF3a (60kD)
, spliceosome associated protein 61