Browse our anti-SMN1 (SMN1) Antibodies

Full name:
anti-Survival of Motor Neuron 1, Telomeric Antibodies (SMN1)
On www.antibodies-online.com are 108 Survival of Motor Neuron 1, Telomeric (SMN1) Antibodies from 16 different suppliers available. Additionally we are shipping SMN1 Kits (29) and SMN1 Proteins (9) and many more products for this protein. A total of 153 SMN1 products are currently listed.
Synonyms:
AEP, AI849087, BCD541, Catf1, GEMIN1, nmd, RIPE3b1, sma, SMA1, SMA2, SMA3, SMA4, SMA@, Smbp-2, Smbp2, Smn, SMN2, SMNT, Smubp2, T-BCD541, TDRD16A
list all antibodies Gene Name GeneID UniProt
SMN1 20589  
SMN1 6606 Q16637
SMN1 64301 O35876

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anti-Mouse (Murine) SMN1 Antibodies:

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Top referenced anti-SMN1 Antibodies

  1. Mouse (Murine) Monoclonal SMN1 Primary Antibody for ICC, FACS - ABIN108567 : Liu, Dreyfuss: A novel nuclear structure containing the survival of motor neurons protein. in The EMBO journal 1996 (PubMed)
    Show all 2 references for 108567

  2. Human Monoclonal SMN1 Primary Antibody for FACS, IHC - ABIN969407 : Hendrickson, Donohoe, Akmaev, Sugarman, Labrousse, Boguslavskiy, Flynn, Rohlfs, Walker, Allitto, Sears, Scholl: Differences in SMN1 allele frequencies among ethnic groups within North America. in Journal of medical genetics 2009 (PubMed)

  3. Dog (Canine) Polyclonal SMN1 Primary Antibody for WB - ABIN2778671 : Hirano, Angelini, Montagna, Hays, Tanji, Mitsumoto, Gordon, Naini, DiMauro, Rowland: Amyotrophic lateral sclerosis with ragged-red fibers. in Archives of neurology 2008 (PubMed)

  4. Human Polyclonal SMN1 Primary Antibody for IHC, ELISA - ABIN1585252 : Smith, Kuliszewski, Liao, Rudenko, Stewart, Leong-Poi: Sustained improvement in perfusion and flow reserve after temporally separated delivery of vascular endothelial growth factor and angiopoietin-1 plasmid deoxyribonucleic acid. in Journal of the American College of Cardiology 2012 (PubMed)

  5. Human Monoclonal SMN1 Primary Antibody for IHC, ELISA - ABIN1585251 : Zhu, Guo, Yao, Yan, Xue, Hao, Zhou, Zhu, Qin, Lu: Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef protein in promotion of angiogenesis and oncogenesis: role of the AKT signaling pathway. in Oncogene 2014 (PubMed)

More Antibodies against SMN1 Interaction Partners

Cow (Bovine) Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. Data show that the coding sequence of survival of motor neuron 2 (SMN2) differs from that of survival motor neuron 1 (SMN1) by a single nucleotide (c.840C>T) at codon 280 in exon 7.

  2. SMN (show SNRPN Antibodies) protein functions in cytoplasmic Sm-core assembly and in the recruitment of the snRNA cap hypermethylase

Mouse (Murine) Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. miR (show MLXIP Antibodies)-431 expression was highly increased, and a number of its putative mRNA targets were significantly downregulated in motor neurons after SMN (show STMN1 Antibodies) loss. Further, we found that miR (show MLXIP Antibodies)-431 regulates motor neuron neurite length by targeting several molecules previously identified to play a role in motor neuron axon outgrowth, including chondrolectin (show CHODL Antibodies)

  2. To determine the dependence of oligodendrocyte (OL)on the Smn (show STMN1 Antibodies) protein(SMN1), we utilized the Smn (show STMN1 Antibodies)-/-;SMN2 (severe) mouse model. Our data suggest that despite the multi-functionality and ubiquitous expression of the Smn (show STMN1 Antibodies) protein, it does not play a key role in myelination of the CNS, at least in the context of spinal muscular atrophy pathogenesis.

  3. our studies show that this G-motif represents a novel and essential determinant for axonal localization of the Anxa2 (show ANXA2 Antibodies) mRNA mediated by the SMN (show STMN1 Antibodies) complex.

  4. A long non-coding RNA (lncRNA) that arises from the antisense strand of SMN (show STMN1 Antibodies), SMN (show STMN1 Antibodies)-AS1 (show ARSB Antibodies), is enriched in neurons and transcriptionally represses SMN (show STMN1 Antibodies) expression by recruiting the epigenetic Polycomb (show CBX2 Antibodies) repressive complex-2.

  5. SMN1 expression restoration is curative in a spinal muscular atrophy model mice.

  6. Survival motor neuron 1, and survival motor neuron 2, depletion results in increased alternative splicing events.

  7. these results demonstrate that SMN (show STMN1 Antibodies) deficiency impacts spleen development and suggests a potential role for immunological development in Spinal muscular atrophy.

  8. Itch monoubiquitinates SMN (show STMN1 Antibodies) and monoubiquitination of SMN (show STMN1 Antibodies) plays an important role in regulating its cellular localization.

  9. muscle does not appear to require high levels of SMN (show STMN1 Antibodies) above what is produced by two copies of SMN2

  10. Findings demonstrate that high expression of SMN (show STMN1 Antibodies) in the motor neuron is both necessary and sufficient for proper function of the motor unit. In addition, SMN (show STMN1 Antibodies) high expression in neurons and glia has a major impact on survival.

Human Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. From the computational analysis, it is also possible that SMN's Lys45 and Asp36 act as two electrostatic clips at the SMN (show STMN1 Antibodies)-Gemin2 (show GEMIN2 Antibodies) complex structure interface

  2. our studies show that this G-motif represents a novel and essential determinant for axonal localization of the Anxa2 (show ANXA2 Antibodies) mRNA mediated by the SMN (show STMN1 Antibodies) complex.

  3. Loss of SMN1 is associated with Spinal muscular atrophy.

  4. A rare variant in exon 7 of SMN1 in three patients affected with type I or type II SMA. Most of the SMN1 transcripts exhibited complete loss of exon 7 in vivo. The variant disrupts Tra2beta1 binding.

  5. These results establish that SMN overexpression in motor neurons slows disease onset and outcome by ameliorating pathological signs in this model of mutant TDP-43-mediated amyotrophic lateral sclerosis (ALS).

  6. A long non-coding RNA (lncRNA) that arises from the antisense strand of SMN (show STMN1 Antibodies), SMN (show STMN1 Antibodies)-AS1 (show PTGDR Antibodies), is enriched in neurons and transcriptionally represses SMN (show STMN1 Antibodies) expression by recruiting the epigenetic Polycomb (show CBX2 Antibodies) repressive complex-2.

  7. We show that genes of the classical apoptosis pathway are involved in the smn-1-mediated neuronal death, and that this phenotype can be rescued by the expression of human SMN1, indicating a functional conservation between the two orthologs. Finally, we determined that Plastin3/plst-1 genetically interacts with smn-1 to prevent degeneration, and that treatment with valproic acid is able to rescue the degenerative phenotype

  8. SMN (show STMN1 Antibodies) functions as a natural inhibitor for IL-1beta (show IL1B Antibodies)-induced NF-kappaB (show NFKB1 Antibodies) signaling by targeting TRAF6 (show TRAF6 Antibodies) and the IKK (show CHUK Antibodies) complex.

  9. U12-dependent intron retention is induced upon siRNA knock-down of SMN1 in HeLa cells.

  10. Deletion in SMN1 gene is associated with spinal muscular atrophy.

Pig (Porcine) Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. first cloning and identification of the swine SMN1 gene and show that there is significant sequence homology between swine and human SMN (show SNRPN Antibodies) throughout the coding region

SMN1 Antigen Profile

Antigen Summary

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy\; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Two transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with SMN1

  • survival of motor neuron 1, telomeric (SMN1) antibody
  • immunoglobulin mu binding protein 2 (Ighmbp2) antibody
  • survival motor neuron 1 (Smn1) antibody
  • survival of motor neuron 1, telomeric (Smn1) antibody
  • survival of motor neuron 1, telomeric-like (LOC100348318) antibody
  • AEP antibody
  • AI849087 antibody
  • BCD541 antibody
  • Catf1 antibody
  • GEMIN1 antibody
  • nmd antibody
  • RIPE3b1 antibody
  • sma antibody
  • SMA1 antibody
  • SMA2 antibody
  • SMA3 antibody
  • SMA4 antibody
  • SMA@ antibody
  • Smbp-2 antibody
  • Smbp2 antibody
  • Smn antibody
  • SMN2 antibody
  • SMNT antibody
  • Smubp2 antibody
  • T-BCD541 antibody
  • TDRD16A antibody

Protein level used designations for SMN1

survival of motor neuron 2, centromeric , survival motor neuron protein , ATP-dependent helicase IGHMBP2 , DNA-binding protein SMUBP-2 , antifreeze enhancer-binding protein , cardiac transcription factor 1 , immunoglobulin S mu binding protein 2 , immunoglobulin mu-binding protein 2 , neuromuscular degeneration , p110 subunit , survival of motor neuron protein , component of gems 1 , gemin-1 , survival motor neuron 1 protein , tudor domain containing 16A , survival motor neuron 1

GENE ID SPECIES
461829 Pan troglodytes
677703 Macaca mulatta
100171813 Pongo abelii
100308165 Bos taurus
20589 Mus musculus
20595 Mus musculus
6606 Homo sapiens
100170853 Sus scrofa
64301 Rattus norvegicus
100713418 Cavia porcellus
281492 Bos taurus
101110178 Ovis aries
100348318 Oryctolagus cuniculus
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