Browse our SMN1 (SMN1) ELISA Kits

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Survival of Motor Neuron 1, Telomeric ELISA Kits (SMN1)
On www.antibodies-online.com are 29 Survival of Motor Neuron 1, Telomeric (SMN1) ELISA Kits from 6 different suppliers available. Additionally we are shipping SMN1 Antibodies (106) and SMN1 Proteins (9) and many more products for this protein. A total of 151 SMN1 products are currently listed.
Synonyms:
AEP, AI849087, BCD541, Catf1, GEMIN1, nmd, RIPE3b1, sma, SMA1, SMA2, SMA3, SMA4, SMA@, Smbp-2, Smbp2, Smn, SMN2, SMNT, Smubp2, T-BCD541, TDRD16A
list all ELISA KIts Gene Name GeneID UniProt
SMN1 20589  
SMN1 6606 Q16637
SMN1 64301 O35876

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More ELISA Kits for SMN1 Interaction Partners

Cow (Bovine) Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. Data show that the coding sequence of survival of motor neuron 2 (SMN2) differs from that of survival motor neuron 1 (SMN1) by a single nucleotide (c.840C>T) at codon 280 in exon 7.

  2. SMN (show SNRPN ELISA Kits) protein functions in cytoplasmic Sm-core assembly and in the recruitment of the snRNA cap hypermethylase

Mouse (Murine) Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. our studies show that this G-motif represents a novel and essential determinant for axonal localization of the Anxa2 (show ANXA2 ELISA Kits) mRNA mediated by the SMN (show STMN1 ELISA Kits) complex.

  2. A long non-coding RNA (lncRNA) that arises from the antisense strand of SMN (show STMN1 ELISA Kits), SMN (show STMN1 ELISA Kits)-AS1 (show ARSB ELISA Kits), is enriched in neurons and transcriptionally represses SMN (show STMN1 ELISA Kits) expression by recruiting the epigenetic Polycomb (show CBX2 ELISA Kits) repressive complex-2.

  3. SMN1 expression restoration is curative in a spinal muscular atrophy model mice.

  4. Survival motor neuron 1, and survival motor neuron 2, depletion results in increased alternative splicing events.

  5. these results demonstrate that SMN (show STMN1 ELISA Kits) deficiency impacts spleen development and suggests a potential role for immunological development in Spinal muscular atrophy.

  6. Itch monoubiquitinates SMN (show STMN1 ELISA Kits) and monoubiquitination of SMN (show STMN1 ELISA Kits) plays an important role in regulating its cellular localization.

  7. muscle does not appear to require high levels of SMN (show STMN1 ELISA Kits) above what is produced by two copies of SMN2

  8. Findings demonstrate that high expression of SMN (show STMN1 ELISA Kits) in the motor neuron is both necessary and sufficient for proper function of the motor unit. In addition, SMN (show STMN1 ELISA Kits) high expression in neurons and glia has a major impact on survival.

  9. This study identifies pathways related to the function of Smn (show STMN1 ELISA Kits) and associated with differential motor unit vulnerability, thus presenting a number of exciting targets for future therapeutic development.

  10. Smn (show STMN1 ELISA Kits) complex deficiency caused constipation, delayed gastric emptying, slow intestinal transit and reduced colonic motility.

Human Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. our studies show that this G-motif represents a novel and essential determinant for axonal localization of the Anxa2 (show ANXA2 ELISA Kits) mRNA mediated by the SMN (show STMN1 ELISA Kits) complex.

  2. Loss of SMN1 is associated with Spinal muscular atrophy.

  3. A rare variant in exon 7 of SMN1 in three patients affected with type I or type II SMA. Most of the SMN1 transcripts exhibited complete loss of exon 7 in vivo. The variant disrupts Tra2beta1 binding.

  4. These results establish that SMN overexpression in motor neurons slows disease onset and outcome by ameliorating pathological signs in this model of mutant TDP-43-mediated amyotrophic lateral sclerosis (ALS).

  5. A long non-coding RNA (lncRNA) that arises from the antisense strand of SMN (show STMN1 ELISA Kits), SMN (show STMN1 ELISA Kits)-AS1 (show PTGDR ELISA Kits), is enriched in neurons and transcriptionally represses SMN (show STMN1 ELISA Kits) expression by recruiting the epigenetic Polycomb (show CBX2 ELISA Kits) repressive complex-2.

  6. We show that genes of the classical apoptosis pathway are involved in the smn-1-mediated neuronal death, and that this phenotype can be rescued by the expression of human SMN1, indicating a functional conservation between the two orthologs. Finally, we determined that Plastin3/plst-1 genetically interacts with smn-1 to prevent degeneration, and that treatment with valproic acid is able to rescue the degenerative phenotype

  7. SMN (show STMN1 ELISA Kits) functions as a natural inhibitor for IL-1beta (show IL1B ELISA Kits)-induced NF-kappaB (show NFKB1 ELISA Kits) signaling by targeting TRAF6 (show TRAF6 ELISA Kits) and the IKK (show CHUK ELISA Kits) complex.

  8. U12-dependent intron retention is induced upon siRNA knock-down of SMN1 in HeLa cells.

  9. Deletion in SMN1 gene is associated with spinal muscular atrophy.

  10. Itch monoubiquitinates SMN (show STMN1 ELISA Kits) and monoubiquitination of SMN (show STMN1 ELISA Kits) plays an important role in regulating its cellular localization.

Pig (Porcine) Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. first cloning and identification of the swine SMN1 gene and show that there is significant sequence homology between swine and human SMN (show SNRPN ELISA Kits) throughout the coding region

SMN1 Antigen Profile

Antigen Summary

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy\; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Two transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with SMN1

  • survival of motor neuron 1, telomeric (SMN1) Elisa Kit
  • immunoglobulin mu binding protein 2 (Ighmbp2) Elisa Kit
  • survival motor neuron 1 (Smn1) Elisa Kit
  • survival of motor neuron 1, telomeric (Smn1) Elisa Kit
  • survival of motor neuron 1, telomeric-like (LOC100348318) Elisa Kit
  • AEP Elisa Kit
  • AI849087 Elisa Kit
  • BCD541 Elisa Kit
  • Catf1 Elisa Kit
  • GEMIN1 Elisa Kit
  • nmd Elisa Kit
  • RIPE3b1 Elisa Kit
  • sma Elisa Kit
  • SMA1 Elisa Kit
  • SMA2 Elisa Kit
  • SMA3 Elisa Kit
  • SMA4 Elisa Kit
  • SMA@ Elisa Kit
  • Smbp-2 Elisa Kit
  • Smbp2 Elisa Kit
  • Smn Elisa Kit
  • SMN2 Elisa Kit
  • SMNT Elisa Kit
  • Smubp2 Elisa Kit
  • T-BCD541 Elisa Kit
  • TDRD16A Elisa Kit

Protein level used designations for SMN1

survival of motor neuron 2, centromeric , survival motor neuron protein , ATP-dependent helicase IGHMBP2 , DNA-binding protein SMUBP-2 , antifreeze enhancer-binding protein , cardiac transcription factor 1 , immunoglobulin S mu binding protein 2 , immunoglobulin mu-binding protein 2 , neuromuscular degeneration , p110 subunit , survival of motor neuron protein , component of gems 1 , gemin-1 , survival motor neuron 1 protein , tudor domain containing 16A , survival motor neuron 1

GENE ID SPECIES
461829 Pan troglodytes
677703 Macaca mulatta
100171813 Pongo abelii
100308165 Bos taurus
20589 Mus musculus
20595 Mus musculus
6606 Homo sapiens
100170853 Sus scrofa
64301 Rattus norvegicus
100713418 Cavia porcellus
281492 Bos taurus
101110178 Ovis aries
100348318 Oryctolagus cuniculus
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