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Browse our SMN1 Proteins (SMN1)

Full name:
Survival of Motor Neuron 1, Telomeric Proteins (SMN1)
On www.antibodies-online.com are 9 Survival of Motor Neuron 1, Telomeric (SMN1) Proteins from 4 different suppliers available. Additionally we are shipping SMN1 Antibodies (111) and SMN1 Kits (27) and many more products for this protein. A total of 154 SMN1 products are currently listed.
Synonyms:
AEP, AI849087, BCD541, Catf1, GEMIN1, nmd, RIPE3b1, sma, SMA1, SMA2, SMA3, SMA4, SMA@, Smbp-2, Smbp2, Smn, SMN2, SMNT, Smubp2, T-BCD541, TDRD16A
list all proteins Gene Name GeneID UniProt
SMN1 20589  
SMN1 6606 Q16637
SMN1 64301 O35876

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SMN1 Proteins (SMN1) by Origin

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More Proteins for SMN1 Interaction Partners

Cow (Bovine) Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. Data show that the coding sequence of survival of motor neuron 2 (SMN2) differs from that of survival motor neuron 1 (SMN1) by a single nucleotide (c.840C>T) at codon 280 in exon 7.

  2. SMN (show SNRPN Proteins) protein functions in cytoplasmic Sm-core assembly and in the recruitment of the snRNA cap hypermethylase

Mouse (Murine) Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. Survival motor neuron 1, and survival motor neuron 2, depletion results in increased alternative splicing events.

  2. these results demonstrate that SMN (show STMN1 Proteins) deficiency impacts spleen development and suggests a potential role for immunological development in Spinal muscular atrophy.

  3. Itch monoubiquitinates SMN (show STMN1 Proteins) and monoubiquitination of SMN (show STMN1 Proteins) plays an important role in regulating its cellular localization.

  4. muscle does not appear to require high levels of SMN (show STMN1 Proteins) above what is produced by two copies of SMN2

  5. Findings demonstrate that high expression of SMN (show STMN1 Proteins) in the motor neuron is both necessary and sufficient for proper function of the motor unit. In addition, SMN (show STMN1 Proteins) high expression in neurons and glia has a major impact on survival.

  6. This study identifies pathways related to the function of Smn (show STMN1 Proteins) and associated with differential motor unit vulnerability, thus presenting a number of exciting targets for future therapeutic development.

  7. Smn (show STMN1 Proteins) complex deficiency caused constipation, delayed gastric emptying, slow intestinal transit and reduced colonic motility.

  8. Primary cell culture and two different SMA model mice to demonstrate that reduced levels of Smn (show STMN1 Proteins) lead to a profound disruption in the expression of myogenic genes.

  9. Results suggest that SMN (show STMN1 Proteins) plays a role in the maintenance of pluripotent embryonic stem cells and neuronal differentiation in mice.

  10. AAV9-mediated SMN (show STMN1 Proteins) gene therapy elicits cure for spinal muscular atrophy.

Human Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. U12-dependent intron retention is induced upon siRNA knock-down of SMN1 in HeLa cells.

  2. Deletion in SMN1 gene is associated with spinal muscular atrophy.

  3. Itch monoubiquitinates SMN (show STMN1 Proteins) and monoubiquitination of SMN (show STMN1 Proteins) plays an important role in regulating its cellular localization.

  4. Data indicate that survival motor neuron 1 protein (SMN1) gene copy number can be precisely determined for the diagnosis of spinal muscular atrophy (SMA).

  5. SMN (show STMN1 Proteins) may assemble translational platforms associated with and governed by the plasma membrane.

  6. A strong correlation was observed between the SMN2 copy number and spinal muscular atrophy phenotype

  7. The results of this study show that, the plasmid containing UTR elements causes to twice more SMN (show STMN1 Proteins) gene expression in transfected cells.

  8. Data show that the coding sequence of survival of motor neuron 2 (SMN2) differs from that of survival motor neuron 1 (SMN1) by a single nucleotide (c.840C>T) at codon 280 in exon 7.

  9. The Cajal bodies fail to recruit SMN (show STMN1 Proteins) and spliceosomal snRNPs, but contain the proteasome activator PA28, a molecular marker associated with the cellular stress response.

  10. PLS3 (show PLS3 Proteins) is a genuine spinal muscular atrophy protective modifier in SMN1-deleted individuals

Pig (Porcine) Survival of Motor Neuron 1, Telomeric (SMN1) interaction partners

  1. first cloning and identification of the swine SMN1 gene and show that there is significant sequence homology between swine and human SMN (show SNRPN Proteins) throughout the coding region

SMN1 Protein Profile

Protein Summary

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy\; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Two transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with SMN1

  • survival of motor neuron 1, telomeric (SMN1)
  • immunoglobulin mu binding protein 2 (Ighmbp2)
  • survival motor neuron 1 (Smn1)
  • survival of motor neuron 1, telomeric (Smn1)
  • survival of motor neuron 1, telomeric-like (LOC100348318)
  • AEP protein
  • AI849087 protein
  • BCD541 protein
  • Catf1 protein
  • GEMIN1 protein
  • nmd protein
  • RIPE3b1 protein
  • sma protein
  • SMA1 protein
  • SMA2 protein
  • SMA3 protein
  • SMA4 protein
  • SMA@ protein
  • Smbp-2 protein
  • Smbp2 protein
  • Smn protein
  • SMN2 protein
  • SMNT protein
  • Smubp2 protein
  • T-BCD541 protein
  • TDRD16A protein

Protein level used designations for SMN1

survival of motor neuron 2, centromeric , survival motor neuron protein , ATP-dependent helicase IGHMBP2 , DNA-binding protein SMUBP-2 , antifreeze enhancer-binding protein , cardiac transcription factor 1 , immunoglobulin S mu binding protein 2 , immunoglobulin mu-binding protein 2 , neuromuscular degeneration , p110 subunit , survival of motor neuron protein , component of gems 1 , gemin-1 , survival motor neuron 1 protein , tudor domain containing 16A , survival motor neuron 1

GENE ID SPECIES
461829 Pan troglodytes
677703 Macaca mulatta
100171813 Pongo abelii
100308165 Bos taurus
20589 Mus musculus
20595 Mus musculus
6606 Homo sapiens
100170853 Sus scrofa
64301 Rattus norvegicus
100713418 Cavia porcellus
281492 Bos taurus
101110178 Ovis aries
100348318 Oryctolagus cuniculus
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