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Data suggest that protein-protein interactions localize U2A' (SNRPA1 (show SNRPA ELISA Kits)) to the U2 snRNP (show LSM2 ELISA Kits) (U2 small nuclear ribonucleoprotein (show RBP31 ELISA Kits)) and exclude it from the U1 snRNP (show LSM2 ELISA Kits), rather than to enhance U2 snRNA (U2 small nuclear RNA; RNU2-1) binding of U2B'' (SNRPB2).
The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.
U2 small nuclear ribonucleoprotein B''
, U2 small nuclear ribonucleoprotein B
, U2 snRNP B''
, small nuclear ribonucleoprotein polypeptide B2