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this study demonstrates that HRS acts as a key component of TLR7 (show TLR7 ELISA Kits) signaling to orchestrate immune and inflammatory responses during EV71 infection
Enhanced SRSF5 Protein Expression Reinforces Lamin A (show LMNA ELISA Kits) mRNA Production in HeLa Cells and Fibroblasts of Progeria Patients
Suggest that SRp40 might be associated with GRalpha transcripts in systemic lupus erythematosus patients.
We show that changes in alternative splicing of hnRNP A/B (show HNRNPAB ELISA Kits), affected by up regulation of SRSF5 (SRp40) or by treatment with C6-ceramide, occur within supraspliceosomes.
Relative levels of SRp20 (show SRSF3 ELISA Kits), SRp30c (show SFRS9 ELISA Kits), and SRp40 in TM cells control differential expression of the two alternatively spliced isoforms of the GR and thereby regulate GC responsiveness.
Here, the authors report that specific SR proteins, particularly SRp40 and SRp55 (show SRSF6 ELISA Kits), promote human immunodeficiency virus type 1 (HIV-1) Gag translation from unspliced (intron-containing) viral RNA.
SRp40 antagonizes ASF/SF2 (show SRSF1 ELISA Kits) and SRp55 (show SRSF6 ELISA Kits) by competing for binding to certain sites in exon 5, thereby promoting TF exon 5 exclusion, an event unique to asTF biosynthesis.
SR proteins 9G8 (show SFRS7 ELISA Kits), SC35 (show SRSF2 ELISA Kits), ASF/SF2 (show SRSF1 ELISA Kits), and SRp40 have effects on the utilization of the A1 to A5 splicing sites of HIV-1 RNA
activates the ESE (exon splicing enhancer) which regulates HIV-1 rev, env, vpu, and nef gene expression
SRp40 regulates the switch in splicing from production of CREMtau(2)alpha to CREMalpha
overexpression of SRSF5 enhances a specific endogenous pre-mRNA splicing event in proliferating cells, but not in differentiating cells, due to proteasome-mediated targeting of both endogenous and transfection-derived SRSF5.
Data show that Akt (show AKT1 ELISA Kits)-mediated signaling promotes protein kinase (show CDK7 ELISA Kits) CbetaII alternative splicing via phosphorylation of SRp40.
the effects of TGF-beta1 (show TGFB1 ELISA Kits) on FN splicing during chondrogenesis may be largely dependent on its effect on SRp40 isoform expression
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein have been found for this gene.
SR splicing factor 5
, delayed-early protein HRS
, pre-mRNA-splicing factor SRP40
, splicing factor, arginine/serine-rich 5
, splicing factor, arginine/serine-rich 5 (SRp40, HRS)
, insulin-induced growth response protein CL-4
, splicing factor arginine/serine-rich 5 (SRp40 HRS)