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The Secretory Pathway Ca(2 (show CA2 ELISA Kits)+) -ATPases SPCA1 (show ATP2C1 ELISA Kits) and SPCA2 are strongly induced under osteogenic conditions that elicit microcalcifications. SPCA (show F7 ELISA Kits) gene expression is significantly elevated in breast cancer subtypes that are associated with microcalcifications.
we found that SPCA2-transfected cells display a higher number of cells entering S phase. Altogether, our results point at the important role of SPCA2 in regulation of cell cycle in cancer cells
Orai1 (show ORAI1 ELISA Kits)-mediated Ca(2 (show CA2 ELISA Kits)+)-influx and SPCA2-mediated Ca(2 (show CA2 ELISA Kits)+) uptake activity into the Golgi/secretory pathway might be coupled possibly in a microdomain. This channel/pump complex may efficiently transfer Ca(2 (show CA2 ELISA Kits)+) into the secretory pathway, which might play a role in SPCA2-expressing secretory cells, such as mammary gland during lactation.
Supporting a more general neurocognition role of ATP2C2 is the previous association of ATP2C2 with attention deficit hyperactivity disorder, a condition commonly comorbid with dyslexia and language impairment.
Findings reveal a signaling pathway in which the Orai1 (show ORAI1 ELISA Kits)-SPCA2 complex elicits constitutive store-independent Ca(2 (show CA2 ELISA Kits)+) signaling that promotes tumorigenesis.
SPCA2 may have a more specialized role in mammalian cells, possibly in cellular detoxification of Mn2+ ions.
hSPCA2 has the ability to transport Ca(2 (show CA2 ELISA Kits)+) and Mn(2+); both its transport and Ca(2 (show CA2 ELISA Kits)+)- and Mn(2+)-dependent phosphoprotein intermediate formation functions are insensitive to thapsigargin inhibition
analysis of SPCA1 (show ATP2C1 ELISA Kits) and SPCA2 isoenzymes by steady-state and transient kinetic analyses
ATP2C2 modulates phonological short-term memory in language impairment.
The goal of this study was to delineate the gene structure and regulation of a novel pancreas-specific isoform for Secretory Pathway Ca(2+) ATPase 2 (termed SPCA2C), which is encoded from the Atp2c2 gene.
SPCA2 and Orai1 (show TMEM132A ELISA Kits) function together to regulate store-independent calcium entry.
Atp2c2 transcription is regulated by MIST1
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity).
ATPase, Ca++ transporting, type 2C, member 2
, calcium-transporting ATPase type 2C member 2-like
, calcium-transporting ATPase 2C2
, secretory pathway Ca,Mn-ATPase
, ATPase 2C2
, calcium-transporting ATPase type 2C member 2
, secretory pathway Ca(2+)-ATPase 2
, secretory pathway calcium ATPase 2
, Secretory pathway Ca(2+)-ATPase 2
, secretory pathway Ca2+-ATPase
, putative secretory pathway Ca-ATPase SPCA2