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Browse our Glycyl-tRNA Synthetase (GARS) ELISA Kits

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Glycyl-tRNA Synthetase ELISA Kits (GARS)
On www.antibodies-online.com are 15 Glycyl-tRNA Synthetase (GARS) ELISA Kits from 8 different suppliers available. Additionally we are shipping Glycyl-tRNA Synthetase Antibodies (60) and Glycyl-tRNA Synthetase Proteins (8) and many more products for this protein. A total of 89 Glycyl-tRNA Synthetase products are currently listed.
Synonyms:
Aat-gly, CG6778, CMT2D, Dmel\\CG6778, DSMAV, fb02f03, gars, GB13467, Gena201, GENA202, GlyRS, GRS, HMN5, MGC79495, Nmf249, RGD1559871, Sgrp23, si:dkey-276i5.1, SMAD1, team, wu:fb02f03
list all ELISA KIts Gene Name GeneID UniProt
GARS 2617 P41250
Mouse GARS GARS 353172 Q9CZD3
Rat GARS GARS 297113  

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Glycyl-tRNA Synthetase (GARS) ELISA Kits by Reactivity

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More ELISA Kits for Glycyl-tRNA Synthetase Interaction Partners

Fruit Fly (Drosophila melanogaster) Glycyl-tRNA Synthetase (GARS) interaction partners

  1. Our findings suggest that mutant GlyRS gains access to ectopic sub-compartments of the motor neuron, providing a possible explanation for the selective neuropathology caused by mutations in a widely expressed gene.

Human Glycyl-tRNA Synthetase (GARS) interaction partners

  1. Data indicate that dimerization is required for the dominant neurotoxicity of disease-associated GARS mutations and provide a rapid, tractable model for studying newly identified GARS variants for a role in human disease.

  2. one of the mRNAs isoforms tightly controls expression and localization of human GARS.

  3. This study reports two crystal structures of human GlyRS variants, in the free form and in complex with tRNA(Gly) respectively, and reveal new aspects of the glycylation mechanism.

  4. GARS mutations are an uncommon cause of Charcot-Marie-Tooth Disease (CMT) in Taiwan. The p.Asp146Tyr and p.Met238Arg mutations are associated with early-onset axonal CMT.

  5. Our findings suggest that mutant GlyRS gains access to ectopic sub-compartments of the motor neuron, providing a possible explanation for the selective neuropathology caused by mutations in a widely expressed gene.

  6. Expression of three CMT-mutant GARS proteins in Drosophila induces defects in motor performance and motor and sensory neuron morphology, and shortens lifespan.

  7. The c.999G>T mutation is a novel mutation of the glycyl-tRNA synthetase gene that has not been previously reported. The phenotype of this family is Charcot-Marie-Tooth disease type 2D, which is first reported in Chinese population.

  8. we propose that the disease-causing L129P mutant of glycyl-tRNA synthetase is linked to a distribution defect in peripheral nerves in vivo.

  9. our data indicate that impaired function is a key component of GARS-mediated CMT disease and emphasize the need for careful genetic and functional evaluation before implicating a variant in disease onset.

  10. We developed an ELISA to detect anti-glycyl-tRNA synthetase by using recombinant protein

Mouse (Murine) Glycyl-tRNA Synthetase (GARS) interaction partners

  1. findings link the selective pathology of Charcot-Marie-Tooth disease type 2D to the neomorphic binding activity of GlyRS(CMT2D) that antagonizes the VEGF (show VEGFA ELISA Kits)-Nrp1 (show NRP1 ELISA Kits) interaction, meaning the VEGF (show VEGFA ELISA Kits)-Nrp1 (show NRP1 ELISA Kits) signalling axis is an actionable target for treating CMT2D

  2. Results indicate that Charcot-Marie-Tooth peripheral neuropathies, type 2D (CMT2D) phenotype is caused by novel pathogenic roles for the mutant GARS that specifically affect peripheral neurons.

  3. a glycyl-tRNA synthetase (GARS) mutation causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy

  4. Gars(C201R) mutation significantly delayed disease onset in the SOD1 (show SOD1 ELISA Kits)(G93A);Gars(C201R/+) double heterozygous mutant mice and increased lifespan by 29% on the genetic background investigated

Zebrafish Glycyl-tRNA Synthetase (GARS) interaction partners

  1. Data indicate that dimerization is required for the dominant neurotoxicity of disease-associated GARS mutations and provide a rapid, tractable model for studying newly identified GARS variants for a role in human disease.

Pig (Porcine) Glycyl-tRNA Synthetase (GARS) interaction partners

  1. Expression levels of ADSL (show ADSL ELISA Kits), GARS-AIRS-GART (show GART ELISA Kits), and DGAT1 (show DGAT1 ELISA Kits) were higher in longissimus lumborum muscle than in heart or liver tissues

Glycyl-tRNA Synthetase (GARS) Antigen Profile

Antigen Summary

This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.

Alternative names and synonyms associated with Glycyl-tRNA Synthetase (GARS)

  • Glycyl-tRNA synthetase (Aats-gly) Elisa Kit
  • glycyl-tRNA synthetase (Aats-gly) Elisa Kit
  • glycyl-tRNA synthetase (GARS) Elisa Kit
  • glycyl-tRNA synthetase (gars) Elisa Kit
  • glycyl-tRNA synthetase (glyQ) Elisa Kit
  • glycyl-tRNA synthetase (TTHA0543) Elisa Kit
  • glycyl-tRNA synthetase (Gars) Elisa Kit
  • glycyl-tRNA synthetase (LOC692991) Elisa Kit
  • glycyl-tRNA synthetase-like (LOC100512260) Elisa Kit
  • Aat-gly Elisa Kit
  • CG6778 Elisa Kit
  • CMT2D Elisa Kit
  • Dmel\\CG6778 Elisa Kit
  • DSMAV Elisa Kit
  • fb02f03 Elisa Kit
  • gars Elisa Kit
  • GB13467 Elisa Kit
  • Gena201 Elisa Kit
  • GENA202 Elisa Kit
  • GlyRS Elisa Kit
  • GRS Elisa Kit
  • HMN5 Elisa Kit
  • MGC79495 Elisa Kit
  • Nmf249 Elisa Kit
  • RGD1559871 Elisa Kit
  • Sgrp23 Elisa Kit
  • si:dkey-276i5.1 Elisa Kit
  • SMAD1 Elisa Kit
  • team Elisa Kit
  • wu:fb02f03 Elisa Kit

Protein level used designations for GARS

Aats-gly-PA , Aats-gly-PB , Aats-gly-PC , CG6778-PA , CG6778-PB , CG6778-PC , glycyl-tRNA synthetase , glycine--tRNA ligase , AP-4-A synthetase , Charcot-Marie-Tooth neuropathy 2D , Charcot-Marie-Tooth neuropathy, neuronal type, D , diadenosine tetraphosphate synthetase , glycine tRNA ligase , glyRS , storage granule protein 23 , glycyl-tran synthetase

GENE ID SPECIES
39644 Drosophila melanogaster
408392 Apis mellifera
463329 Pan troglodytes
475268 Canis lupus familiaris
493218 Xenopus (Silurana) tropicalis
884595 Chlamydia trachomatis D/UW-3/CX
3169948 Thermus thermophilus HB8
100388470 Callithrix jacchus
2617 Homo sapiens
353172 Mus musculus
297113 Rattus norvegicus
337230 Danio rerio
446482 Xenopus laevis
428403 Gallus gallus
408010 Bos taurus
692991 Bombyx mori
100174405 Pongo abelii
100512260 Sus scrofa
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