Browse our Glycyl-tRNA Synthetase Proteins (GARS)

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Glycyl-tRNA Synthetase Proteins (GARS)
On www.antibodies-online.com are 9 Glycyl-tRNA Synthetase (GARS) Proteins from 5 different suppliers available. Additionally we are shipping Glycyl-tRNA Synthetase Antibodies (69) and Glycyl-tRNA Synthetase Kits (17) and many more products for this protein. A total of 101 Glycyl-tRNA Synthetase products are currently listed.
Synonyms:
Aat-gly, CG6778, CMT2D, Dmel\\CG6778, DSMAV, fb02f03, gars, GB13467, Gena201, GENA202, GlyRS, GRS, HMN5, MGC79495, Nmf249, RGD1559871, Sgrp23, si:dkey-276i5.1, SMAD1, team, wu:fb02f03
list all proteins Gene Name GeneID UniProt
GARS 2617 P41250
GARS 353172 Q9CZD3
GARS 297113  

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Glycyl-tRNA Synthetase Proteins (GARS) by Origin

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More Proteins for Glycyl-tRNA Synthetase Interaction Partners

Fruit Fly (Drosophila melanogaster) Glycyl-tRNA Synthetase (GARS) interaction partners

  1. Our findings suggest that mutant GlyRS gains access to ectopic sub-compartments of the motor neuron, providing a possible explanation for the selective neuropathology caused by mutations in a widely expressed gene.

Human Glycyl-tRNA Synthetase (GARS) interaction partners

  1. At the active site, a glycyl-AMP (show APRT Proteins) molecule is synthesized and is waiting for the transfer of the glycyl moiety to occur.

  2. GlyRS functions as a chaperone that critically supports neddylation.

  3. Data indicate that dimerization is required for the dominant neurotoxicity of disease-associated GARS mutations and provide a rapid, tractable model for studying newly identified GARS variants for a role in human disease.

  4. one of the mRNAs isoforms tightly controls expression and localization of human GARS.

  5. This study reports two crystal structures of human GlyRS variants, in the free form and in complex with tRNA(Gly) respectively, and reveal new aspects of the glycylation mechanism.

  6. GARS mutations are an uncommon cause of Charcot-Marie-Tooth Disease (CMT) in Taiwan. The p.Asp146Tyr and p.Met238Arg mutations are associated with early-onset axonal CMT.

  7. Our findings suggest that mutant GlyRS gains access to ectopic sub-compartments of the motor neuron, providing a possible explanation for the selective neuropathology caused by mutations in a widely expressed gene.

  8. Expression of three CMT-mutant GARS proteins in Drosophila induces defects in motor performance and motor and sensory neuron morphology, and shortens lifespan.

  9. The c.999G>T mutation is a novel mutation of the glycyl-tRNA synthetase gene that has not been previously reported. The phenotype of this family is Charcot-Marie-Tooth disease type 2D, which is first reported in Chinese population.

  10. we propose that the disease-causing L129P mutant of glycyl-tRNA synthetase is linked to a distribution defect in peripheral nerves in vivo.

Mouse (Murine) Glycyl-tRNA Synthetase (GARS) interaction partners

  1. findings link the selective pathology of Charcot-Marie-Tooth disease type 2D to the neomorphic binding activity of GlyRS(CMT2D) that antagonizes the VEGF (show VEGFA Proteins)-Nrp1 (show NRP1 Proteins) interaction, meaning the VEGF (show VEGFA Proteins)-Nrp1 (show NRP1 Proteins) signalling axis is an actionable target for treating CMT2D

  2. Results indicate that Charcot-Marie-Tooth peripheral neuropathies, type 2D (CMT2D) phenotype is caused by novel pathogenic roles for the mutant GARS that specifically affect peripheral neurons.

  3. a glycyl-tRNA synthetase (GARS) mutation causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy

  4. Gars(C201R) mutation significantly delayed disease onset in the SOD1 (show SOD1 Proteins)(G93A);Gars(C201R/+) double heterozygous mutant mice and increased lifespan by 29% on the genetic background investigated

Zebrafish Glycyl-tRNA Synthetase (GARS) interaction partners

  1. Data indicate that dimerization is required for the dominant neurotoxicity of disease-associated GARS mutations and provide a rapid, tractable model for studying newly identified GARS variants for a role in human disease.

Pig (Porcine) Glycyl-tRNA Synthetase (GARS) interaction partners

  1. Expression levels of ADSL (show ADSL Proteins), GARS-AIRS-GART (show GART Proteins), and DGAT1 (show DGAT1 Proteins) were higher in longissimus lumborum muscle than in heart or liver tissues

Glycyl-tRNA Synthetase (GARS) Protein Profile

Protein Summary

This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.

Alternative names and synonyms associated with Glycyl-tRNA Synthetase (GARS)

  • Glycyl-tRNA synthetase (Aats-gly)
  • glycyl-tRNA synthetase (Aats-gly)
  • glycyl-tRNA synthetase (GARS)
  • glycyl-tRNA synthetase (gars)
  • glycyl-tRNA synthetase (glyQ)
  • glycyl-tRNA synthetase (TTHA0543)
  • glycyl-tRNA synthetase (Gars)
  • glycyl-tRNA synthetase (LOC692991)
  • glycyl-tRNA synthetase-like (LOC100512260)
  • Aat-gly protein
  • CG6778 protein
  • CMT2D protein
  • Dmel\\CG6778 protein
  • DSMAV protein
  • fb02f03 protein
  • gars protein
  • GB13467 protein
  • Gena201 protein
  • GENA202 protein
  • GlyRS protein
  • GRS protein
  • HMN5 protein
  • MGC79495 protein
  • Nmf249 protein
  • RGD1559871 protein
  • Sgrp23 protein
  • si:dkey-276i5.1 protein
  • SMAD1 protein
  • team protein
  • wu:fb02f03 protein

Protein level used designations for Glycyl-tRNA Synthetase Proteins (GARS)

Aats-gly-PA , Aats-gly-PB , Aats-gly-PC , CG6778-PA , CG6778-PB , CG6778-PC , glycyl-tRNA synthetase , glycine--tRNA ligase , AP-4-A synthetase , Charcot-Marie-Tooth neuropathy 2D , Charcot-Marie-Tooth neuropathy, neuronal type, D , diadenosine tetraphosphate synthetase , glycine tRNA ligase , glyRS , storage granule protein 23 , glycyl-tran synthetase

GENE ID SPECIES
39644 Drosophila melanogaster
408392 Apis mellifera
463329 Pan troglodytes
475268 Canis lupus familiaris
493218 Xenopus (Silurana) tropicalis
884595 Chlamydia trachomatis D/UW-3/CX
3169948 Thermus thermophilus HB8
100388470 Callithrix jacchus
2617 Homo sapiens
353172 Mus musculus
297113 Rattus norvegicus
337230 Danio rerio
446482 Xenopus laevis
428403 Gallus gallus
408010 Bos taurus
692991 Bombyx mori
100174405 Pongo abelii
100512260 Sus scrofa
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