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High MAT2A expression is associated with tamoxifen-resistant breast cancer.
METTL16 (show METTL16 ELISA Kits) that controls MAT2A intron retention in response to intracellular SAM (show TTN ELISA Kits) levels; splicing of the MAT2A retained intron is rapidly induced upon Met depletion, and this effect requires a conserved hairpin which is a METTL16 (show METTL16 ELISA Kits) m6A (show GPM6A ELISA Kits) substrate.
S-adenosyl-L-methionine (show AS3MT ELISA Kits) diminishes hepatitis C virus expression by altering MAT1A (show MAT1A ELISA Kits)/2A signaling in hepatocytes.
methionine adenosyltransferase II alpha (MAT2A), and the arginine methyltransferase, PRMT5 (show PRMT5 ELISA Kits), as vulnerable enzymes in cells with MTAP (show MTAP ELISA Kits) deletion.
acet (show EP300 ELISA Kits)ylation decreased in hepatocellular cancer
The data presented here support the conclusion that rare genetic variants in MAT2A predispose individuals to thoracic aortic disease.
Results suggest that MAT2A is downregulated in cancer tissues of renal cell carcinomas patients and has function of tumor suppressor though repressing the expression of heme oxygenase-1 (show HMOX1 ELISA Kits).
Liver-specific isoenzyme MAT1A (show MAT1A ELISA Kits) is genetically linked with an inborn metabolic disorder of hypermethioninemia, as well as a ubiquitously expressed isoenzyme MAT2A, whose enzymatic activity is regulated by an associated subunit MAT2B (show MAT2B ELISA Kits).
Differential gene expression of BACE1 (show BACE ELISA Kits) and PSEN1 (show PSEN1 ELISA Kits) in the knockdown cells, which is possibly a consequence of MAT2A deregulation and may indicate a self regulatory mechanism.
we found for the first time a post-transcriptional regulation of MAT1A (show MAT1A ELISA Kits) and MAT2A by AUF1 (show HNRNPD ELISA Kits) and HuR (show ELAVL1 ELISA Kits) in hepatocellular carcinoma.
SIRT1 (show SIRT1 ELISA Kits) knock-out embryos display reduced Mat2a expression and histone methylation and are sensitive to maternal methionine restriction-induced lethality, whereas maternal methionine supplementation increases the survival of SIRT1 (show SIRT1 ELISA Kits) knock-out newborn mice.
P300 (show NOTCH1 ELISA Kits) acetylates MAT IIalpha at lysine residue 81 and destabilizes MAT IIalpha by promoting its ubiquitylation and subsequent proteasomal degradation.
MATIIalpha represses the expression of cyclooxygenase 2 (COX-2 (show PTGS2 ELISA Kits)), encoded by Ptgs2 (show PTGS2 ELISA Kits), by specifically interacting with histone H3K9 methyltransferase SETDB1 (show SETDB1 ELISA Kits).
Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf (show MAF ELISA Kits) oncoprotein
MAT2A and MAT2beta (show MAT2B ELISA Kits) genes are induced during hepatic stellate cell activation
up-regulation of MAT2A also provides a growth advantage and s-adenosylmethionine and methylthioadenosine can block mitogenic signaling in colon cancer cells.
The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes.
methionine adenosyltransferase II, alpha
, S-adenosylmethionine synthetase isoform type-2-like
, MAT 2
, S-adenosylmethionine synthase isoform type-2
, adoMet synthase 2
, adoMet synthetase 2
, methionine adenosyltransferase 2
, S-adenosylmethionine synthetase isoform type-2
, non-hepatic-type S-adenosylmethionine synthetase