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Human Polyclonal PRDX3 Primary Antibody for IF (p), IHC (p) - ABIN735713
Gao, Liu, Chen, Lv, Wu, Mi, Wang: Comparative study of Hsp27, GSK3?, Wnt1 and PRDX3 in Hirschsprung's disease. in International journal of experimental pathology 2014
Human Polyclonal PRDX3 Primary Antibody for IF, WB - ABIN524343
Kannan, Nguyen, Makarem, Dong, Shih, Eirew, Raouf, Emerman, Eaves: Glutathione-dependent and -independent oxidative stress-control mechanisms distinguish normal human mammary epithelial cell subsets. in Proceedings of the National Academy of Sciences of the United States of America 2014
Human Polyclonal PRDX3 Primary Antibody for IF, WB - ABIN524344
Liu, Rong, Li, Liu, Wang, Li: Vasectomy induces oxidative stress and up-regulates the expression of peroxiredoxins in mouse testis in short and early periods after surgery. in The Journal of urology 2014
PRDX3 knockdown led to the down-regulation of ATP synthases and the decreased cellular ATP level, contributing to the slow-down of cell growth. Furthermore, silencing PRDX3 enhanced invasive properties of HepG2 cells via TIMP-1 (show TIMP1 Antibodies) down-regulation and the increased ECM (show MMRN1 Antibodies) degradation
Prx3 and Trx2 (show TXN2 Antibodies) comprise an adaptive system to sense changes in atmospheric oxygen tension and influence cellular injury responses through both detoxification of mitochondrial oxidants and regulation of mitochondrial redox-dependent signaling
PRX3 plays a crucial role in mitochondrial homeostasis.
High PRX3 expression is associated with invasion of lung adenocarcinoma.
We also found that forkhead box (show FOXO Antibodies) protein 1 (FOXM1 (show FOXM1 Antibodies))-induced peroxiredoxin 3 (PRDX3) maintains the mitochondrial function, and the FOXM1 (show FOXM1 Antibodies)/PRDX3 mitochondrial pathway maintains survival of colon CSCs
Oxidative stress promotes PRX2 (show PRDX2 Antibodies) and PRX3 hyperoxidation and attenuates pro-survival signaling in aging chondrocytes.
the species with one disulfide and one hyperoxidized active site was decameric for Prx2 (show PRDX2 Antibodies) and dimeric for Prx3. Reduction and re-oxidation of the hyperoxidized dimer of Prx3 produced hyperoxidized monomers
Data indicate that peroxiredoxin III (PrxIII) is a common direct target of both miroRNAs miR (show MLXIP Antibodies)-26a-5p and miR (show MLXIP Antibodies)-23b-3p.
Colon cancer stem cells overexpress the mitochondrial gene PRX3, which is required for maintenance of mitochondrial function and tumorigenesis, and is regulated by forkhead box protein 1, which also regulates expression of CD133 in these cells.
High serum PRDX3 levels are associated with hepatocellular carcinoma.
The importance of mitochondrial Prdx3 in regulating the oxidative stress environment in adipocytes.Loss of Prdx3 leads to decreased pS473 Akt (show AKT1 Antibodies) and insulin (show INS Antibodies)-stimulated glucose transport.
Oxidative stress promotes PRX2 (show PRRX2 Antibodies) and PRX3 hyperoxidation and attenuates pro-survival signaling in aging chondrocytes.
This study showed that from E10.5,Prdx3 showed strong ventral lateral expression. This increased ventral immunotaining persisted until E18.5 but became relatively less striking at later stages.
Prx3 plays a crucial role in mitochondrial homeostasis and thereby controls the contractile functions of skeletal muscle.
The SirT1 (show SIRT1 Antibodies) regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase (show SOD2 Antibodies), catalase (show CAT Antibodies), peroxiredoxins 3 and 5, thioredoxin 2 (show TXN2 Antibodies), thioredoxin reductase 2 (show TXNRD2 Antibodies), and uncoupling protein 2 (show UCP2 Antibodies).
Prx3 is up-regulated in response to oxidative stress; the maintenance of Prx3 levels in hair cells is a critical factor in their susceptibility to acquired hearing loss.
The concerted action of PrxIII and Srx (show SRX1 Antibodies) is important for protection against pyrazole-induced oxidative stress arising from the convergent induction of CYP2E1 (show CYP2E1 Antibodies)-derived and ER stress-derived ROS (show ROS1 Antibodies) in mitochondria.
PrxIII in mouse adrenal cortex is inactivated by H(2)O(2) produced by cytochrome P450 (show CYP Antibodies) enzymes during corticosterone production stimulated by adrenocorticotropic hormone.
endogenous Prx3 may play an essential role in maintaining normal characteristics of adipocytes and that defect in Prx3 alters mitochondrial redox state and function.
Immunohistochemical analysis revealed segment-specific alterations induced by the ischemic insult. Grx2 (show GRX2 Antibodies), Prx3, and Prx6 (show PRDX6 Antibodies) were highly expressed in proximal tubule cells
Data suggest that during ectogenesis of blastocysts infected with bovine Herpesvirus type 5, expression of AOP-1 is induced; this effect may be involved in inhibition of apoptosis in infected blastocysts/embryos.
PRDX3, also known as SP-22, is a mitochondrial 2-CYS (show DNAJC5 Antibodies) peroxiredoxin organized as a decameric toroid
This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.
thioredoxin-dependent peroxide reductase, mitochondrial
, peroxiredoxin 3
, mitochondrial thioredoxin-dependent peroxide reductase
, antioxidant protein 1
, peroxiredoxin III
, protein MER5 homolog
, Prx III
, anti-oxidant protein 1
, antioxidant protein
, mitochondrial Trx dependent peroxide reductase
, mitochondrial thioredoxin dependent peroxide reductase
, PRx III
, 5'-methylthioadenosine phosphorylase
, MTA phosphorylase
, anti-oxidant like protein-1