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UCK1 and 2 are both expressed in several neuroblastoma (show ARHGEF16 Proteins) cell lines, including four MYCN (show MYCN Proteins) single copy cell lines and five MYCN (show MYCN Proteins) amplified cell lines
ribavirin is a potential substrate of UCK-1, and RMP formed could be chemically coupled to AsOR to form a conjugate for liver specific targeting.
This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms.
uridine-cytidine kinase 1
, UCK 1
, cytidine monophosphokinase 1
, uridine monophosphokinase 1
, uridine monophosphate kinase