Browse our Uridine Monophosphate Synthetase Proteins (UMPS)

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Uridine Monophosphate Synthetase Proteins (UMPS)
On www.antibodies-online.com are 8 Uridine Monophosphate Synthetase (UMPS) Proteins from 5 different suppliers available. Additionally we are shipping Uridine Monophosphate Synthetase Antibodies (32) and Uridine Monophosphate Synthetase Kits (1) and many more products for this protein. A total of 45 Uridine Monophosphate Synthetase products are currently listed.
Synonyms:
1700095D23Rik, AA408257, AL033308, BB164745, OPRT, UMPS, zgc:55702, zgc:55723
list all proteins Gene Name GeneID UniProt
UMPS 7372 P11172
UMPS 22247 P13439
Rat UMPS UMPS 288051  

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Uridine Monophosphate Synthetase Proteins (UMPS) by Origin

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Top referenced Uridine Monophosphate Synthetase Proteins

  1. Human UMPS Protein expressed in Escherichia coli (E. coli) - ABIN1098695 : Suchi, Mizuno, Kawai, Tsuboi, Sumi, Okajima, Hodgson, Ogawa, Wada: Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families. in American journal of human genetics 1997 (PubMed)
    Show all 2 references for 1098695

  2. Human UMPS Protein expressed in HEK-293 Cells - ABIN2735007 : Bardeleben, Sharma, Reeve, Bassilian, Frost, Hoang, Shi, Lichtenstein: Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-β-riboside-induced apoptosis in multiple myeloma cells. in Molecular cancer therapeutics 2013 (PubMed)

More Proteins for Uridine Monophosphate Synthetase Interaction Partners

Caenorhabditis elegans (C. elegans) Uridine Monophosphate Synthetase (UMPS) interaction partners

  1. the conserved uridine monophosphate phosphoribosyltransferase (UMPS), which acts in pyrimidine biosynthesis, is required for NAD(+) biosynthesis in place of the missing QPRTase (show QPRT Proteins)

Human Uridine Monophosphate Synthetase (UMPS) interaction partners

  1. Partial UMPS-deficiency should be included in the differential diagnosis of mild orotic aciduria.

  2. The UMPS 638 CC genotype might be a candidate biomarker predicting toxicity in patients receiving tegafur-uracil/leucovorin-based preoperative chemoradiation for locally advanced rectal cancer

  3. OPRT transition state analogues identify crucial components of potent inhibitors targeting OPRT enzymes.

  4. The observed mutations, aberrant splicing and downregulation of UMPS represent novel mechanisms for acquired 5-FU resistance in colorectal cancer

  5. [review] It is confirmed that the type I defect in hereditary orotic aciduria is caused by loss of uridine monophosphate (UMP)synthase activity

  6. OPRT expression in colorectal carcinoma tissues is not correlated with the toxicity of 5-FU, but OPRT expression in the normal tissues can help predict the toxicity associated with 5-FU.

  7. High expression levels of orotate phosphoribosyl transferase and thymidylate synthase (show TYMS Proteins) in colorectal cancer appear to be significantly involved in metastasis after curative surgery

  8. Although no association was detected between UMPS variants and gastrointestinal cancer risk in Caucasians, polymerase chain reaction-RFLP with BsrI digestion and DHPLC set up at 59 degrees C are reliable and cost-effective methods to genotype UMPS.

  9. orotate phosphoribosyl transferase/DPD (show DPYD Proteins) ratio has a relation to cancer staging and survival rate.

  10. Increased orotate phosphoribosyltransferase expression is associated with bladder cancers.

Uridine Monophosphate Synthetase (UMPS) Protein Profile

Protein Summary

This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with Uridine Monophosphate Synthetase (UMPS)

  • Uridine MonoPhosphate Synthetase (umps-1)
  • uridine monophosphate synthetase (umps)
  • uridine monophosphate synthetase (UMPS)
  • uridine monophosphate synthetase (Umps)
  • 1700095D23Rik protein
  • AA408257 protein
  • AL033308 protein
  • BB164745 protein
  • OPRT protein
  • UMPS protein
  • zgc:55702 protein
  • zgc:55723 protein

Protein level used designations for UMPS

Uridine MonoPhosphate Synthetase family member (umps-1) , uridine 5'-monophosphate synthase , uridine monophosphate synthetase , uridine monophosphate synthase , uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) , OMPdecase , OPRTase , UMP synthase , orotate phosphoribosyltransferase , orotidine 5'-phosphate decarboxylase , orotate phosphoribosyl transferase and orotidine-5'-decarboxylase

GENE ID SPECIES
176453 Caenorhabditis elegans
393143 Danio rerio
494728 Xenopus laevis
100070386 Equus caballus
100353794 Oryctolagus cuniculus
100556619 Anolis carolinensis
424256 Gallus gallus
460644 Pan troglodytes
496817 Xenopus (Silurana) tropicalis
715664 Macaca mulatta
780512 Ovis aries
7372 Homo sapiens
478593 Canis lupus familiaris
281568 Bos taurus
22247 Mus musculus
288051 Rattus norvegicus
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