antibodies-online.com | News | New Antibodies

Cancer diagnostics research: anti-Mitotic cells antibody

news@antikoerper-online.de (David Kitz Kramer) — Thu, 11 Mar 2010 15:35:00 +0100

The cell cycle of eukaryotic cells consists of various phases. Two of them can be identified morphologically and biochemically. The first phase that can be distinguished happens during cell mitosis (M-phase), in which the cell divides into two identical daughter cells; chromosome condensation and spindle formation are microscopically visible. The second discernible phase is the S-phase where the DNA of a cell is replicated. Antibodies recognizing the phases of the cell cycle are of value for example in cancer research.

Broadly applicable: Nitro Tyrosine Antibody

news@antikoerper-online.de (David Kitz Kramer) — Thu, 11 Mar 2010 15:08:00 +0100

Tyrosine nitration is a posttranslational modification generated by a nitrogen free radical (peroxinitrite ONOO^-). This reactive nitrogen specie reacts with macromolecules of the organism and alters their functions. This modification can lead to cell death during cell-stress conditions. Nitration is involved in many signalling pathways and plays a role in diverse research-areas ranging from Alzheimer's Disease over Immunology to Virology.

Frequently cited: Antibody detects antibacterial protein Cathelicidin

news@antikoerper-online.de (David Kitz Kramer) — Thu, 11 Mar 2010 11:40:00 +0100

Cathelicidin acts as effector of the innate immune system and possesses antimicrobial and immunomodulatory functions. Cathelicidin binds to bacterial lipopolysaccharides, and hence serves a critical role in the mammalian immune defence against bacterial infection. These peptides have been isolated from several species of mammals, and are part of a family of proteins situated in specific granules of polymorphonuclear leukocytes.

New research-area: Autophagy

news@antikoerper-online.de (David Kitz Kramer) — Wed, 10 Mar 2010 16:17:00 +0100

Autophagy is a cell-function that takes care of destruction and recycling of cell components. Thereby autophagy assures a balance between synthesis and catalysis of cell components. Autophagy is also part of the immune response, and belongs to the innate immune system. Malfunctions of autophagy can lead to development of various diseases. Now antibodies-online.com offers more than 140 antibodies for research in the field of autophagy.

New antibody: Enhanced Green Fluorescent Protein (EGFP) antibody

news@antikoerper-online.de (David Kitz Kramer) — Tue, 09 Mar 2010 16:27:00 +0100

The Enhanced Green Fluorescent Protein (EGFP) is a 29 kDa recombinant protein that emits fluorescent light of a wavelength of 488/507 nm. This Protein A purified rabbit polyclonal antibody detects EGFP and is specifically suitable for western blotting applications. In the 1960s and 1970s GFP was first purified from Aequorea victoria. It was not until the early 1990s that molecular biologists succeeded in utilizing wtGFP as a tool with multiple applications in genetics and molecular biology. EGFP has been optimized for brighter fluorescence and expression in mammalian cells.

More product information: »Show datasheet

Superior quality antibody: hsc70 (hsp-like) antibody frequently cited

news@antikoerper-online.de (David Kitz Kramer) — Tue, 09 Mar 2010 15:23:00 +0100

Heat shock proteins (HSP) support the maintenance of three dimensional structures of proteins for instance by protecting them from denaturation due to heat. They can be found everywhere in the organism and are expressed extensively, for example, under stress condition caused by exposure to high heat, UV-rays or ethanol.

Epigenetics tool: 5-Methylcytidine antibody

news@antikoerper-online.de (David Kitz Kramer) — Mon, 08 Mar 2010 14:23:00 +0100

This 5-methylcytidine (5meC or 5-MeCyd) antibody is a commonly use reference in epigenetic research that allows to detect methylation of cytidines. DNA methylation is a DNA modification process, which is involved in the control of gene expression, which leads to genes being silenced or enhanced in their expression having pre-recursions for a large variety of disorders. Recently, this part of genetics has become a vibrant research area that spans various fields of molecular biology and genetics. The importance of epigenetics lies in the fact that it has a great impact on the phenotype despite identical genotypes.

Recent study uses cystathionase antibody from antibodies-online.com

news@antikoerper-online.de (David Kitz Kramer) — Wed, 03 Mar 2010 17:40:00 +0100

Cancer cells have a high demand for cysteine as precursor of the antioxidant, glutathione, that is required to promote cell growth and division. The aim of a recent study by S Kandil, L Brennan, and GJ McBean, was to evaluate the relative contribution of different metabolic pathways to glutathione synthesis in astrocytoma/glioblastoma cells. The major finding was, that glutathione depletion causes a JNK- and p38MAPK -mediated increase in expression of cystathionine-γ-lyase that promotes flux through the transsulfuration pathway to compensate for loss of glutathione in C6 glioma cells. This study has been carried out with antibodies supplied by antibodies-online.com.

Frequently used: phospho-AKT1 monoclonal antibody

news@antikoerper-online.de (David Kitz Kramer) — Tue, 02 Mar 2010 11:39:00 +0100

There are three members in the AKT protein family in humans: AKT1, AKT2, and AKT3. These enzymes are members of the serine/threonine-specific protein kinase family. AKT1 (or AKT without numeral) regulates many downstream effectors. AKT1 is able to induce protein synthesis pathways, and is therefore a key signalling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth.

ELISA kits from CUSABIO

news@antikoerper-online.de (David Kitz Kramer) — Fri, 19 Feb 2010 12:47:00 +0100

antibodies-online.com now offers you ELISA kits from the company CUSABIO. Here you will find more than 4.000 ELISA kits from CUSABIO.

PCNA : Frequently published antibody

news@antikoerper-online.de (David Kitz Kramer) — Fri, 19 Feb 2010 10:53:00 +0100

Proliferating cell nuclear antigen (PCNA) plays a key role in DNA replication, repair, cell cycle regulation, and post-replicative transactions like DNA methylation and chromatin remodeling. It is an essential cellular component, originally characterized as playing an important role in dividing cells. PCNA is evolutionary highly conserved from yeast to human.

Oxidative Stress: Frequently used Antibody against 8-OHDG

news@antikoerper-online.de (David Kitz Kramer) — Wed, 17 Feb 2010 11:28:00 +0100

8-hydroxy-2'-deoxyguanosine (8 Hydroxyguanosine, 8-OHDG) is a product of damaged DNA. The anti-8-OHDG antibody (clone N45-1) is highly specific for 8 Hydroxyguanosine (8-OHDG) and has been tested for immunhistochemistry. This anti-8-OHDG antibody (clone N45-1) has been used in many published studies. The list of publications and information on cross-reactivity can be found on the »datasheet.

New: Interferon (IFN) gamma antibody

news@antikoerper-online.de (David Kitz Kramer) — Tue, 16 Feb 2010 17:43:00 +0100

IFNs belong to the large class of glycoproteins known as cytokines. As a immunresponse they are secreted due to exposure of pathogens, such as viruses, bacteria, or parasites Here you may find an anti-interferon (IFN) gamma antibody, which has been raised in rabbit.

Lactate Dehydrogenase (LDH): Frequently cited antibody

news@antikoerper-online.de (David Kitz Kramer) — Tue, 16 Feb 2010 16:09:00 +0100

In general, lactate dehydrogenase (LDH) is often used as a marker of tissue breakdown. lactate dehydrogenase shows a cytoplasmic localization. Lactate dehydrogenase is also known as L-lactate dehydrogenase A chain, LDH-A, LDH muscle subunit and LDH-M.

Glutamate Dehydrogenase: Frequently cited antibody

news@antikoerper-online.de (David Kitz Kramer) — Thu, 11 Feb 2010 15:29:00 +0100

Glutamate is a majorexcitatory neurotransmitter. One enzyme central to the metabolism of glutamate is glutamate dehydrogenase (GDH 1 , EC 1.4.1.3), that catalyzes the reversible deamination of L-glutamate to 2-oxoglutarate using NAD+ or NADP+. Mammalian GDH is composed of six identical subunits, and the regulation of GDH is very complex.