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WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells
Downregulation of the ARP2 (show ACTR2 Proteins)/3 complex signaling pathway, a common final pathway for multiple signaling cascades that regulate the actin cytoskeleton, would compromise the structural stability of spines, leading to their loss. In concert with findings from deletion of the ARP2 (show ACTR2 Proteins)/3 complex in mice, these findings support the idea that spine deficits in the DLPFC may contribute to subcortical hyperdopaminergia in schizophrenia.
Recent reports now demonstrate a novel aspect of the ARP2 (show ACTR2 Proteins)/3 complex and the nucleating-promoting factors in the maintenance of endothelial barrier function and junction remodeling of established endothelial cell junctions.
FOXF1 (show FOXF1 Proteins) repressed cell growth and expression of collagen-1 and actin-related protein 2 (show ACTR2 Proteins)/3 complex, subunit 2 (show CCT2 Proteins).
The Arp2 (show ACTR2 Proteins)/3 complex is recruited to invading Rickettsia parkeri and is required for efficient invasion.
Filopodia initiation: focus on the Arp2 (show ACTR2 Proteins)/3 complex and formins
Endogenous Nogo-B (show RTN4 Proteins), which may exert its effects through ARPC 2/3 and MYL-9 (show MYL9 Proteins), is necessary for the migration and contraction of airway smooth muscle cells.
The results identify Arp2/3 complex as a key factor in the generation of the dynamic actin cluster during mitosis.
Arp2/3 complex genes have roles in actin organization and possibly in cancer phenotypes
The actin-related protein 2 (show ACTR2 Proteins) accumulated in punctate structures that formed an extensivenetwork in a region corresponding to the postition of the Golgi complex.
The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin.
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.
actin related protein 2/3 complex, subunit 2, 34kDa
, actin related protein 2/3 complex subunit 2
, actin-related protein 2/3 complex subunit 2
, arp2/3 complex 34 kDa subunit
, ARP2/3 protein complex subunit 34
, actin related protein 2/3 complex, subunit 2 (34 kD)