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|Antigen||AXL Receptor tyrosine Kinase (AXL) Antibodies|
|Conjugate||This AXL antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-AXL AntibodyTarget Details AXL Application Details Handling References for anti-AXL antibody (ABIN359785) Images
|Specificity||This antibody reacts to AXL.|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human AXL.|
Target Details AXLProduct Details anti-AXL Antibody Application Details Handling References for anti-AXL antibody (ABIN359785) Images back to top
|Alternative Name||AXL / UFO (AXL Antibody Abstract)|
|Background||AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains.Synonyms: Tyrosine-protein kinase receptor UFO|
|Gene ID||558, 9606|
|Pathways||RTK Signaling, Cellular Response to Molecule of Bacterial Origin|
Application DetailsProduct Details anti-AXL Antibody Target Details AXL Handling References for anti-AXL antibody (ABIN359785) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-AXL Antibody Target Details AXL Application Details References for anti-AXL antibody (ABIN359785) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-AXL antibody (ABIN359785)Product Details anti-AXL Antibody Target Details AXL Application Details Handling Images back to top
Lee, Strunk, Spritz: "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes." in: Oncogene, Vol. 8, Issue 12, pp. 3403-10, 1993
Janssen, Schulz, Steenvoorden, Schmidberger, Strehl, Ambros, Bartram: "A novel putative tyrosine kinase receptor with oncogenic potential." in: Oncogene, Vol. 6, Issue 11, pp. 2113-20, 1991
OBryan, Frye, Cogswell, Neubauer, Kitch, Prokop, Espinosa, Le Beau, Earp, Liu: "axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase." in: Molecular and cellular biology, Vol. 11, Issue 10, pp. 5016-31, 1991
Partanen, Mäkelä, Alitalo, Lehväslaiho, Alitalo: "Putative tyrosine kinases expressed in K-562 human leukemia cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 22, pp. 8913-7, 1991
ImagesProduct Details anti-AXL Antibody Target Details AXL Application Details Handling References for anti-AXL antibody (ABIN359785) back to top