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Axl plays an essential role in the regulation of NK cell development as well as natural killer effector function.
Matrix metalloproteases ADAM10 and TACE (ADAM17) cleave AXL receptor tyrosine kinase (Axl) in lupus-prone leukocytes.
Gas6 (show GAS6 Antibodies)/Axl and Akt (show AKT1 Antibodies)/FoxO1a (show FOXO1 Antibodies) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.
results establish TAM (show CCNA1 Antibodies) receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease
These results suggest that TAM (show CCNA1 Antibodies) receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.
Gas6 (show GAS6 Antibodies)-induced Axl signaling is a critical driver of pancreatic cancer progression.
The results indicate that Axl and Mer (show ERH Antibodies) receptors cooperatively regulate the systemic immune tolerance to male germ cell antigens.
Vascular depletion of Axl reduced vein graft stiffness. Axl expression determined the STAT1 (show STAT1 Antibodies)-SOCS1 (show SOCS1 Antibodies) balance in vein graft intima and progression of the remodeling.
Gas6 (show GAS6 Antibodies)/Axl signaling is essential for delaying the cellular senescence process regulated by the PI3K/Akt (show AKT1 Antibodies)/FoxO (show FOXO3 Antibodies) signaling pathway.
activation of receptor tyrosine kinase (show RET Antibodies) Axl inhibits the osteogenic differentiation of vascular pericytes.
Study provides evidence that AXL and MET are associated with cell proliferation and metastasis in lung cancer, and the crosstalk between these receptors affects tumor progression.
these results confirm the correlation between AXL and PKCalpha (show PKCa Antibodies), and suggest PKCalpha (show PKCa Antibodies)-AXL signaling may be a treatment target, particularly in malignant cancer cells.
Authors concluded that the molecular mechanisms of AXL mediated resistance involved in the increased activity of the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and MAPK (show MAPK1 Antibodies)/ERK1/2 (show MAPK1/3 Antibodies) pathways, and AXL overexpression could promote resistance, but it can be weakened when AXL expression is silenced.
The study suggests that Axl may play a role in the function of endothelial progenitor cells, thereby being involved in the pathogenesis of preeclampsia.
Data show that strong AXL expression in surgically resected that lung adenocarcinomas (LADs) was a predictor of poor prognosis.
In this paper, we review the biology of the Gas6 (show GAS6 Antibodies)/Tyro3 (show TYRO3 Antibodies), Axl, and MerTK (show MERTK Antibodies)(collectively named TAM (show CCNA1 Antibodies) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .
Data show that mononuclear leukocytes (PBMC) AXL receptor tyrosine kinase (Axl) is rescued by combined matrix metalloproteases ADAM10 (show ADAM10 Antibodies) and TACE (ADAM17 (show ADAM17 Antibodies)) inhibition.
suggest that targeting receptor tyrosine kinase (show RET Antibodies) AXL (RTK-AXL) with BMS-777607 could represent a regimen for the treatment of primary and recurrent glioblastoma multiforme (GBM).
AXL is frequently expressed in high-grade serous ovarian cancers and its expression is significantly associated to tumors displaying poor prognosis.
Data suggest that AXL receptor tyrosine kinase (Axl) may facilitate tumour progression by promoting nasopharyngeal carcinoma (NPC (show NPC1 Antibodies)) cell migration and invasion.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
, tyrosine-protein kinase receptor UFO
, ufo oncogene homolog
, AXL receptor tyrosine kinase
, tyrosine-protein kinase receptor UFO-like
, AXL oncogene
, AXL transforming sequence/gene