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Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.
results establish TAM (show CCNA1 Antibodies) receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease
These results suggest that TAM (show CCNA1 Antibodies) receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.
Gas6 (show GAS6 Antibodies)-induced Axl signaling is a critical driver of pancreatic cancer progression.
The results indicate that Axl and Mer (show ERH Antibodies) receptors cooperatively regulate the systemic immune tolerance to male germ cell antigens.
Vascular depletion of Axl reduced vein graft stiffness. Axl expression determined the STAT1 (show STAT1 Antibodies)-SOCS1 (show SOCS1 Antibodies) balance in vein graft intima and progression of the remodeling.
Gas6 (show GAS6 Antibodies)/Axl signaling is essential for delaying the cellular senescence process regulated by the PI3K/Akt (show AKT1 Antibodies)/FoxO (show FOXO3 Antibodies) signaling pathway.
Low MITF (show MITF Antibodies)/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.
nuclear receptor agonists increase MerTK (show MERTK Antibodies) and Axl expression on plaque-associated immune cells, consequently licensing their phagocytic activity and promoting plaque clearance.
Optimal TAM (show CCNA1 Antibodies) signaling requires coincident TAM (show CCNA1 Antibodies) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (show CCNA1 Antibodies) receptor tyrosine kinases Tyro3 (show TYRO3 Antibodies), Axl, and Mer (show ERH Antibodies) and their ligands Gas6 (show GAS6 Antibodies) and Protein S.
activation of receptor tyrosine kinase (show RET Antibodies) Axl inhibits the osteogenic differentiation of vascular pericytes.
Incubation with sunitinib of renal cell carcinoma (show MOK Antibodies) cells causes significant upregulation of multiple phosphopeptides including Axl.
Identified an Axl-associated signature of 62 genes able to portray the high-grade ovarian cancer patients with the shortest overall survival.
AXL may have a role in proliferation, migration and survival in colorectal cancer cells
High HIF-1alpha expression is significantly associated with Axl and VEGF expression, and with markers of poor prognosis in this series of breast cancer.
Negative feedback regulation of AXL by miR (show MLXIP Antibodies)-34a modulates apoptosis in lung cancer cells by activating the transcription factor ELK1 (show ELK1 Antibodies) via the JNK (show MAPK8 Antibodies) signaling pathway.
patients possessing the favourable IFNL3 (show IL28B Antibodies) rs12979860 genotype associated with treatment response, showed lower AXL expression in the liver and a stronger induction of AXL in the blood, following their first dose of IFN.
Forced overexpression of Axl in LNCaP cells decreased metformin and taxotere sensitivity and knockdown of Axl in resistant cells increased sensitivity to these drugs.
The mRNA expression levels of Tyro-3 (show TYRO3 Antibodies), Axl were decreased in pSS (show CDSN Antibodies) patients. When considering the plasma level, increased levels of soluble Mer (show MERTK Antibodies) was observed with statistically significant difference.
Both CSF (show CSF2 Antibodies) and plasma Axl levels are significantly elevated in ruptured intracranial aneurysm patients.
Our data suggest that miR (show MLXIP Antibodies)-34a may function as a tumor suppressor through repression of oncogenic AXL in ovarian cancer
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
, tyrosine-protein kinase receptor UFO
, ufo oncogene homolog
, AXL receptor tyrosine kinase
, tyrosine-protein kinase receptor UFO-like
, AXL oncogene
, AXL transforming sequence/gene