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Mouse (Murine) AXL ELISA Kit for Sandwich ELISA - ABIN1889307
OBryan, Frye, Cogswell, Neubauer, Kitch, Prokop, Espinosa, Le Beau, Earp, Liu: axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. in Molecular and cellular biology 1991
suggest that targeting receptor tyrosine kinase (show RET ELISA Kits) AXL (RTK-AXL) with BMS-777607 could represent a regimen for the treatment of primary and recurrent glioblastoma multiforme (GBM).
AXL is frequently expressed in high-grade serous ovarian cancers and its expression is significantly associated to tumors displaying poor prognosis.
Data suggest that AXL receptor tyrosine kinase (Axl) may facilitate tumour progression by promoting nasopharyngeal carcinoma (NPC (show NPC1 ELISA Kits)) cell migration and invasion.
High expression of Axl correlated with Upper Tract Urothelial Carcinoma.
Vimentin (show VIM ELISA Kits) and Axl mRNA and protein were expressed in a subset of human TNBC tumors.
Incubation with sunitinib of renal cell carcinoma cells causes significant upregulation of multiple phosphopeptides including Axl.
Identified an Axl-associated signature of 62 genes able to portray the high-grade ovarian cancer patients with the shortest overall survival.
AXL may have a role in proliferation, migration and survival in colorectal cancer cells
High HIF-1alpha expression is significantly associated with Axl and VEGF expression, and with markers of poor prognosis in this series of breast cancer.
Negative feedback regulation of AXL by miR (show MLXIP ELISA Kits)-34a modulates apoptosis in lung cancer cells by activating the transcription factor ELK1 (show ELK1 ELISA Kits) via the JNK (show MAPK8 ELISA Kits) signaling pathway.
Gas6 (show GAS6 ELISA Kits)/Axl and Akt (show AKT1 ELISA Kits)/FoxO1a (show FOXO1 ELISA Kits) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.
results establish TAM (show CCNA1 ELISA Kits) receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease
These results suggest that TAM (show CCNA1 ELISA Kits) receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.
Gas6 (show GAS6 ELISA Kits)-induced Axl signaling is a critical driver of pancreatic cancer progression.
The results indicate that Axl and Mer (show ERH ELISA Kits) receptors cooperatively regulate the systemic immune tolerance to male germ cell antigens.
Vascular depletion of Axl reduced vein graft stiffness. Axl expression determined the STAT1 (show STAT1 ELISA Kits)-SOCS1 (show SOCS1 ELISA Kits) balance in vein graft intima and progression of the remodeling.
Gas6 (show GAS6 ELISA Kits)/Axl signaling is essential for delaying the cellular senescence process regulated by the PI3K/Akt (show AKT1 ELISA Kits)/FoxO (show FOXO3 ELISA Kits) signaling pathway.
Low MITF (show MITF ELISA Kits)/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.
nuclear receptor agonists increase MerTK (show MERTK ELISA Kits) and Axl expression on plaque-associated immune cells, consequently licensing their phagocytic activity and promoting plaque clearance.
activation of receptor tyrosine kinase (show RET ELISA Kits) Axl inhibits the osteogenic differentiation of vascular pericytes.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
, AXL transforming sequence/gene
, tyrosine-protein kinase receptor UFO
, adhesion-related kinase
, ufo oncogene homolog