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Browse our BDNF Proteins (BDNF)

Full name:
Brain-Derived Neurotrophic Factor Proteins (BDNF)
On are 89 Brain-Derived Neurotrophic Factor (BDNF) Proteins from 19 different suppliers available. Additionally we are shipping BDNF Antibodies (277) and BDNF Kits (136) and many more products for this protein. A total of 521 BDNF products are currently listed.
ANON2, bdnf, bdnf-A, BULN2
list all proteins Gene Name GeneID UniProt
BDNF 12064 P21237
BDNF 627 P23560
BDNF 24225 P23363

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BDNF Proteins (BDNF) by Origin

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Top referenced BDNF Proteins

  1. Human BDNF Protein expressed in Escherichia coli (E. coli) - ABIN1046638 : Jones, Reichardt: Molecular cloning of a human gene that is a member of the nerve growth factor family. in Proceedings of the National Academy of Sciences of the United States of America 1990 (PubMed)
    Show all 2 references for ABIN1046638

  2. Human BDNF Protein expressed in Escherichia coli (E. coli) - ABIN2681231 : Skup: BDNF and NT-3 widen the scope of neurotrophin activity: pharmacological implications. in Acta neurobiologiae experimentalis 1994 (PubMed)

  3. Human BDNF Protein expressed in Escherichia coli (E. coli) - ABIN413062 : Kobayashi, Saito, Sato, Furusawa, Hosokawa, Tsutsumi, Asada, Kamada, Ohshima, Hisanaga: Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5. in The Journal of biological chemistry 2014 (PubMed)

  4. Human BDNF Protein expressed in Wheat germ - ABIN1346621 : Martin Bauknight, Chakrabarty, Hwang, Malone, Joshi, Bruce, Sander Connolly, Winfree, Cunningham, Martin, Haque: Convection enhanced drug delivery of BDNF through a microcannula in a rodent model to strengthen connectivity of a peripheral motor nerve bridge model to bypass spinal cord injury. in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2012 (PubMed)

More Proteins for BDNF Interaction Partners

Zebrafish Brain-Derived Neurotrophic Factor (BDNF) interaction partners

  1. BDNF-TrkB (show NTRK2 Proteins) influences the expression level of components of chemokine (show CCL1 Proteins) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.

  2. Light regulates the expression of the BDNF/TrkB2 (show NTRK2 Proteins) system in the adult zebrafish retina.

  3. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (show RACGAP1 Proteins) (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3 (show PARD3 Proteins)) protein.

  4. the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons

  5. The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB (show NTRK2 Proteins) in zebrafish.

  6. The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript

  7. Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin (show HTT Proteins) knockdown in zebrafish.

Xenopus laevis Brain-Derived Neurotrophic Factor (BDNF) interaction partners

  1. Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.

  2. BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway

  3. Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein (show MAG Proteins) .

  4. These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.

  5. In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC (show POMC Proteins)-derived alphaMSH (show POMC Proteins), and that the light controls the biosynthesis and secretion of BDNF and of POMC (show POMC Proteins) end-products.

  6. BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.

  7. BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.

  8. BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis

  9. BDNF induces glial cell proliferation as well as axonal outgrowth and myelination in vivo.

  10. PACAP stimulates the expression of BDNF transcript IV.

Rhesus Monkey Brain-Derived Neurotrophic Factor (BDNF) interaction partners

  1. Study showed that complex relationships exist between BDNF/TrkB (show NTRK2 Proteins) gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence

  2. In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC (show Arc Proteins) expressions are strongly correlated with spontaneous physical activity.

  3. A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.

  4. In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.

Mouse (Murine) Brain-Derived Neurotrophic Factor (BDNF) interaction partners

  1. that BDNF expressed in taste receptor cells is required to maintain normal levels of innervation in adulthood

  2. BDNF expression levels in hypothalamic and adipose tissue were markedly down-regulated in mice with monosodium glutamate (show GRIN1 Proteins) induced obesity.

  3. Study indicates that diminished mature BDNF trophic signaling through the TrkB (show NTRK2 Proteins) receptor, rather than an induction in proBDNF, is a main contributing factor to the vulnerability of striatal neurons in the zQ175 HD mouse model

  4. decapitation at 20:00 h is the best time for BDNF-related measurement in chronic mild stress experiment, since the difference reaches the maximum

  5. Alcohol enhances the psychostimulant and conditioning effects of mephedrone in adolescent mice; postulation of unique roles of D3 receptors and BDNF in place preference acquisition

  6. PLD1 participates in BDNF-induced signaling in cortical neurons.

  7. BDNF application can rescue the morphological deficits in hippocampal pyramidal neurons devoid of Jacob (show NELF Proteins). Taken together, the data suggest that the absence of Jacob (show NELF Proteins) in early development interrupts a positive feedback loop between BDNF signaling

  8. Brain ischaemia induces shedding of a BDNF-scavenger ectodomain from TrkB (show NTRK2 Proteins) receptors by excitotoxicity activation of metalloproteinases and gamma-secretases.

  9. This report showed that reduced BDNF signaling leads to elevation of STEP61 both in BDNF(+/-) mice and after acute BDNF knockdown in cortical cultures.

  10. Brain-derived neurotrophic factor (BDNF) and its specific receptor, tropomyosin (show TPM2 Proteins)-related kinase (TrkB (show NTRK2 Proteins)), have a role the in pathophysiology of depression.

Human Brain-Derived Neurotrophic Factor (BDNF) interaction partners

  1. Participants without the BDNF val(66)met polymorphism showed larger ipsilesional primary sensorimotor cortex activation volume and magnitude after stroke compared with those in whom the polymorphism was present

  2. Genetic variants of BDNF in adults with newly diagnosed epilepsy were associated with cognitive changes over the first year.

  3. the high-intensity interval-training protocol might represent an effective and preferred intervention for elevating BDNF levels and potentially promoting brain health

  4. The involvement of the BDNF Val66Met polymorphism is a common genetic susceptibility for obsessive-compulsive disorder and Tourette syndrome in the Chinese Han population, showing specific gender trends.

  5. Reduction in the concentration of BDNF in the acute phase of stroke is a factor for poor prognosis in terms of the functional status of patients on the 90th day after onset

  6. PFOS may inhibit BDNF-ERK (show EPHB2 Proteins)-CREB (show CREB1 Proteins) signalling by increasing miR (show MLXIP Proteins)-22 levels, which may, in part, explain the mechanism of PFOS neurotoxicity

  7. BDNF DNA methylation (show HELLS Proteins) may contribute to structural white matter changes in major depressive disorder.

  8. Findings suggest that brain-derived neurotrophic factor promotes the growth of neurons in vitro through crosstalk with the Wnt/beta-catenin signaling pathway, and that this interaction may be mediated by glycogen synthase kinase 3 beta.

  9. These findings suggest implication of the Val66Met polymorphism BDNF mutation in the development and severity of cervical spondylotic myelopathy

  10. Suggest that improved vascular function in individuals with greater functional capacity is mediated, at least partially, by an enhanced serum BDNF level.

Cow (Bovine) Brain-Derived Neurotrophic Factor (BDNF) interaction partners

  1. These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin (show INS Proteins) and leptin (show LEP Proteins).

  2. Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.

Pig (Porcine) Brain-Derived Neurotrophic Factor (BDNF) interaction partners

  1. Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.

  2. Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.

  3. FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (show MMP9 Proteins) and MMP-2 (show MMP2 Proteins), caspase-3 (show CASP3 Proteins) and BDNF

BDNF Protein Profile

Protein Summary

The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene.

Alternative names and synonyms associated with BDNF

  • brain-derived neurotrophic factor (bdnf)
  • brain-derived neurotrophic factor (bdnf-A)
  • brain-derived neurotrophic factor (BDNF)
  • brain derived neurotrophic factor (Bdnf)
  • brain-derived neurotrophic factor (Bdnf)
  • brain-derived neurotrophic factor (bdnf-b)
  • brain-derived neurotrophic factor-like (LOC100356949)
  • ANON2 protein
  • bdnf protein
  • bdnf-A protein
  • BULN2 protein

Protein level used designations for BDNF

brain-derived neurotrophic factor , brain derived neurotrophic factor , anorexia BDNF , abrineurin , neurotrophin , brain derived neurothrophic factor , neurotrophic factor , pre-pro-brain-derived

58118 Danio rerio
378585 Xenopus laevis
554233 Monodelphis domestica
701245 Macaca mulatta
751584 Taeniopygia guttata
100037853 Xenopus (Silurana) tropicalis
100135487 Cavia porcellus
100313500 Oncorhynchus mykiss
12064 Mus musculus
627 Homo sapiens
24225 Rattus norvegicus
617701 Bos taurus
396186 Gallus gallus
100730257 Cavia porcellus
397495 Sus scrofa
100009689 Equus caballus
403461 Canis lupus familiaris
493690 Felis catus
101117275 Ovis aries
100048914 Xenopus laevis
100500698 Ailuropoda melanoleuca
503511 Pan troglodytes
100356949 Oryctolagus cuniculus
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