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Human BDNF Protein expressed in Escherichia coli (E. coli) - ABIN1046638
Jones, Reichardt: Molecular cloning of a human gene that is a member of the nerve growth factor family. in Proceedings of the National Academy of Sciences of the United States of America 1990
Show all 2 references for ABIN1046638
Human BDNF Protein expressed in Escherichia coli (E. coli) - ABIN413062
Kobayashi, Saito, Sato, Furusawa, Hosokawa, Tsutsumi, Asada, Kamada, Ohshima, Hisanaga: Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5. in The Journal of biological chemistry 2014
Human BDNF Protein expressed in Wheat germ - ABIN1346621
Martin Bauknight, Chakrabarty, Hwang, Malone, Joshi, Bruce, Sander Connolly, Winfree, Cunningham, Martin, Haque: Convection enhanced drug delivery of BDNF through a microcannula in a rodent model to strengthen connectivity of a peripheral motor nerve bridge model to bypass spinal cord injury. in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2012
These results suggest an involvement of the BDNF/TrkB (show NTRK2 Proteins) system in the regulation of food intake and energy balance in zebrafish, as in mammals
BDNF-TrkB (show NTRK2 Proteins) influences the expression level of components of chemokine (show CCL1 Proteins) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF/TrkB2 (show NTRK2 Proteins) system in the adult zebrafish retina.
Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (show RACGAP1 Proteins) (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3 (show PARD3 Proteins)) protein.
the results demonstrate that bdnf mediates non-cell-autonomous maintenance of position and thereby the identity of differentiated neurons
The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB (show NTRK2 Proteins) in zebrafish.
The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript
Loss of BDNF is a major cause of the developmental abnormalities seen with huntingtin (show HTT Proteins) knockdown in zebrafish.
Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system.
BDNF suppresses neuromuscular junction maturation through cAMP-PKA signaling pathway
Findings demonstrate the neurotrophin, BDNF-dependent formation of integrin beta1-based adhesions in the growth cone and reveal how a positive regulator of substrate adhesions can block the negative remodeling and growth inhibitory effects of myelin-associated glycoprotein (show MAG Proteins) .
These results indicate that brief sensory stimulation, by initiating nuclear transcription and de novo protein synthesis of BDNF, can facilitate the refinement of response properties in the developing visual system.
In the Xenopus melanotrope, BDNF biosynthesis and processing occur along the secretory granule maturation axis, together with that of POMC (show POMC Proteins)-derived alphaMSH (show POMC Proteins), and that the light controls the biosynthesis and secretion of BDNF and of POMC (show POMC Proteins) end-products.
BDNF released from the neural lobe of the pituitary gland acts as a neurohormone stimulating the secretory activity of the melanotrope cells in the intermediate pituitary lobe.
BDNF influences synaptic connectivity in multiple ways, promoting not only the morphological maturation of axonal arbors but also their stabilization, but also their stabilization.
BDNF, in addition to its neural and hormonal roles, can be released as a neurohormone from the neural pituitary lobe of X. laevis
BDNF induces glial cell proliferation as well as axonal outgrowth and myelination in vivo.
PACAP stimulates the expression of BDNF transcript IV.
Study showed that complex relationships exist between BDNF/TrkB (show NTRK2 Proteins) gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC (show Arc Proteins) expressions are strongly correlated with spontaneous physical activity.
A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.
In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.
Inhibition of BDNF-AS protected retinal ganglion cells against ischemia by increasing the levels of BDNF.
Human microvascular endothelial cells promote the development of dorsal root ganglion neurons via BDNF pathway in a co-culture system.
Results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the brain-derived neurotrophic factor -ERK1/2-cAMP response element-binding protein pathway through tropomyosin receptor kinase (show NTRK1 Proteins) B activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.
The decrease in ARC (show NOL3 Proteins) BDNF may support increased feeding in food-deprived mice, whereas the increase in the VMH may moderate overeating in WD-fed mice.
The results of the present study identify BDNF expression within mesocorticolimbic brain structures as a reasonable target for further investigations into the neural mechanisms underlying ABA.
BDNF triggers multiple effects including neuronal intrinsic growth capacity improvement and distal portion atrophy protection to promote behavioral recovery following sciatic nerve crush injury in mouse.
the nicotine-induced decrease in BDNF was inhibited in the presence of mecamylamine. We also detected a3 and b4 mRNA in intestinal mucosal cells and a3 protein expression in intestinal enteroendocrine cells. We conclude that STC-1 (show STC1 Proteins) cells and intestinal enteroendocrine cells express nAChRs.
loss of DTNBP1 (show DTNBP1 Proteins) in pyramidal neurons diminished activity-dependent secretion of brain-derived neurotrophic factor (BDNF).
FTY720-treated Tg mice had reduced aSyn aggregation and less constipation, occurring in part by increasing both pro-BDNF and mature BDNF levels.
Expression levels of brain derived neurotrophic factor, postsynaptic density 95, and p-cyclic-AMP response element binding protein levels were significantly elevated in the testosterone (T) group, but flutamide reduced the T-induced effects in these biomarkers to control levels.
genetic association/nutrigenomic studies in population in South Korea: Data suggest that an SNP in BDNF (rs6265) is negatively associated with type 2 diabetes; BDNF Val/Met and Met/Met variants (rs6265) decrease risk for glucose intolerance and type 2 diabetes. Middle-aged individuals with BDNF Val/Val are prone to developing type 2 diabetes even with low energy intake and low protein intake.
The results of the present study show that the BDNF Val66Met polymorphism is an important moderator of the relation between child maltreatment and reappraisal ability, and that this G x E interaction fits a strong differential susceptibility model.
Significant associations were identified at 3.5 years old for TMEM18 (show TMM18 Proteins) rs6548238, NEGR1 (show NEGR1 Proteins) rs2815752, BDNF rs10767664 and rs6265 (1 year old and 3.5 years old) with anthropometric phenotypes
Role of BDNF gene variants in susceptibility to schizophrenia and in some aspects of cognitive function.
Significant differences of serum BDNF levels were found between male patients with schizophrenia with and without metabolic syndrome, but not in females. This finding suggested the gender difference behind the mechanism of BDNF in metabolic syndrome in schizophrenia.
BDNF mutations are associated with Obesity.
TPH2 (show TDO2 Proteins) SNP rs4570625 interaction with BDNF Val66Met predicts a high-risk emotional phenotype
Results indicated that phosphorylation of glycogen synthase kinase 3beta at Ser9 might be involved in Human endogenous retrovirus W family envelope (HERV-W env (show ERVW-1 Proteins))-induced brain-derived neurotrophic factor expression, and will hopefully improve our understanding of the role of HERV-W env (show ERVW-1 Proteins) in neurological and psychiatric diseases (schizophrenia, etc).
the prevalence of phantosmia in the general older population is not negligible and that some factors that are beneficial for preserved olfactory function, such as female gender and the BDNF met allele, are also associated with the occurrence of phantom smells.
These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin (show INS Proteins) and leptin (show LEP Proteins).
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.
Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin factor (BDNF) signaling pathway.
Taken together, these data indicate that recurrent tethering stress in sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated by an overactive neuroendocrine system.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (show MMP9 Proteins) and MMP-2 (show MMP2 Proteins), caspase-3 (show CASP3 Proteins) and BDNF
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene.
brain-derived neurotrophic factor
, brain derived neurotrophic factor
, anorexia BDNF
, brain derived neurothrophic factor
, neurotrophic factor