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CXCL8 (show IL8 Proteins) production from lung cancer cells could be initiated by an autocrine mechanism or external sources of BTC.
Data suggest that BTC (betacellulin), AREG (amphiregulin (show AREG Proteins)), and EREG (epiregulin (show EREG Proteins)) induced prostaglandin E2 production by induction of COX-2 (prostaglandin-endoperoxide synthase 2 (show PTGS2 Proteins)) through MAP kinase (show MAPK1 Proteins) signaling in granulosa cells.
BTC has properties of increasing retinal vascular leakage that could contribute to the development of diabetic retinopathy.
Data suggest a novel receptor-independent role for betacellulin intracellular-domain fragment signaling due to its ability to inhibit cell growth in vitro.
These are the first data that demonstrate an influence of betacellulin upon mesenchymal stem cells and the first to implicate HIF-alpha in betacellulin-mediated proliferation.
The solution structure of the EGF (show EGF Proteins)-like domain of betacellulin has been determined using two-dimensional nuclear magnetic resonance spectroscopy
Betacellulin and heregulin/NDF (show NRG1 Proteins)-alpha are involved in epidermal morphogenesis and/or in maintenance of the differentiated phenotype.
although BTC and EGF share overlapping signaling properties, the ability of BTC to enhance Erk activation occurs independent of Ras.
BTC may play a pivotal role as a local growth factor in promoting the differentiated villous trophoblastic function via ErbB-1 (show EGFR Proteins) in early placentas and in contributing to placental growth through EVT cell function via ErbB-4 (show ERBB4 Proteins) in term placentas.
Betacellulin is expressed in malignant fibrous histiocytoma and is a regulator of tumor growth.
BTC induces expansion of neural stem cells and neuroblasts, and promotes neurogenesis in the olfactory bulb and dentate gyrus.
Betacellulin exerts proliferative activity on beta cells through the activation of ErbB-1 (show EGFR Proteins) and ErbB-2 (show ERBB2 Proteins) receptors
BTC overexpression enhances glucose-induced insulin (show INS Proteins) secretion in Mesenchyma Stem Cells
Betacellulin protects from pancreatitis by activating stress-activated protein kinase.
Excess of betacellulin exerts no deleterious effects on the structure or function of the male reproductive tract in mice.
structure of the BTC gene
Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling.
epidermal growth factor (EGF (show EGF Proteins)) family members amphiregulin (show AREG Proteins), epiregulin (show EREG Proteins), and beta-cellulin are paracrine mediators that propagate the LH signal throughout the ovulatory follicle
Mice overexpressing BTC exhibit high early postnatal mortality, reduced body weight gain, impaired longitudinal growth, cataract, retinal and bone abnormalities, and lung disease.
identified hitherto unknown effects of betacellulin (BTC) overabundance in reproduction and suggests BTC as a novel candidate protein for the modulation of fertility.
The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor.