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Mouse (Murine) CSF1 Protein expressed in HEK-293 - ABIN2666672
Erblich, Zhu, Etgen, Dobrenis, Pollard: Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits. in PLoS ONE 2011
Show all 6 references for ABIN2666672
Human CSF1 Protein expressed in Yeast - ABIN2004781
Pandit, Bohm, Jancarik, Halenbeck, Koths, Kim: Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor. in Science (New York, N.Y.) 1993
Show all 4 references for ABIN2004781
Mouse (Murine) CSF1 Protein expressed in Human Cells - ABIN2008633
Tokai, Kawasaki, Kikuchi, Ouchi: Cloning and characterization of the CSF1 gene of Saccharomyces cerevisiae, which is required for nutrient uptake at low temperature. in Journal of bacteriology 2000
Show all 4 references for ABIN2008633
Human CSF1 Protein expressed in Human Cells - ABIN2004779
Fan, Fan, Gewant, Royce, Nanes, Rubin: Increasing membrane-bound MCSF does not enhance OPGL-driven osteoclastogenesis from marrow cells. in American journal of physiology. Endocrinology and metabolism 2001
Show all 4 references for ABIN2004779
Human CSF1 Protein expressed in Escherichia coli (E. coli) - ABIN413611
Del Galdo, Wermuth, Addya, Fortina, Jimenez et al.: NF?B activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of ... in Annals of the rheumatic diseases 2010
the high level of colony-stimulating factor 1 expression during bovine pregnancy in uteroplacental tissues is consistent with its proposed role in placental physiology
results suggest that leukemia inhibitory factor (show LIF Proteins) and macrophage-colony stimulating factor (show CSF2 Proteins) are produced in the endometrium and may play different roles in early and mid-pregnancy
These results indicate that BARF1 blockade of CSF-1 signaling is an important immune evasion strategy for efficient acute EBV infection and a significant determinant for virus setpoint during persistent EBV infection.
the complete sequencing of M-CSF (show CSF1R Proteins) genes, gene organizaztion,splice varaiants, gene expression, and M-CSF (show CSF1R Proteins) role in the immune system
M-CSF macrophage conversion into foam cells reduces their proinflammatory responses to classical M1-polarizing activation
This can be achieved by either blocking the EGF (show EGF Proteins) or CSF-1 receptors or supressing the EGF (show EGF Proteins) or CSF-1 signal.
findings demonstrated that M-CSF binds to IL-34 (show IL34 Proteins); molecular docking studies predicted the formation of a heteromeric M-CSF/IL-34 (show IL34 Proteins) cytokine
RGC-32 (show C13orf15 Proteins) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4 (show IL4 Proteins).
Data show crystal structures of CSF1-CSF1R (show CSF1R Proteins) ternary complexes, and propose a mechanism for their cooperative action that relies on the adoption by dimeric CSF-1 of an active conformational state and homotypic receptor interactions.
In patients with CLE (show EIF2B5 Proteins), 100 and 150 mg PD-0360324 (monoclonal antibody against MCSF) every 2 weeks for 3 months suppressed a subset of circulating monocytes.
peripheral nerve injury induced de novo expression of colony-stimulating factor 1 (CSF1) in injured sensory neurons. CSF1 was transported to the spinal cord, where it targeted the microglial CSF1 receptor (CSF1R (show CSF1R Proteins)).
These findings highlight an essential role for PRKAA1 (show PRKAA1 Proteins)-mediated autophagy during differentiation of human monocytes.
These findings suggest a high usefulness of M-CSF in diagnosing the serous sub-type of epithelial ovarian cancer and in discriminating between cancer and non-carcinoma lesions
expression and release, from osteoblasts of macrophage colony-stimulating factor (show CSF2 Proteins) (M-CSF), which is indispensable for osteoclast differentiation, was inhibited by uPAR (show PLAUR Proteins) loss.
study concludes that Langerhans cells require IL-34 (show IL34 Proteins) when residing in fully differentiated and anatomically intact skin epidermis, but rely on neutrophil-derived CSF1 during inflamma
Proteomic Analysis Reveals Distinct Metabolic Differences Between Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF (show CSF2 Proteins)) and Macrophage Colony Stimulating Factor (show CSF2 Proteins) (M-CSF (show CSF1R Proteins)) Grown Macrophages Derived from Murine Bone Marrow Cells
Hematopoietic cells can be induced by M-CSF (show CSF1R Proteins) to dedifferentiate to multipotent stem cells.
M-CSF (show CSF1R Proteins) promotes macrophagic over granulocytic differentiation by inducing ERK (show EPHB2 Proteins) activation but also PKCd (show PKCd Proteins) expression, which in turn, down-regulates Fli-1 (show FLI1 Proteins) expression and prevents granulocytic differentiation.
Results identify CSF-1-activated macrophages as crucial mediators of detrimental Schwann cell dedifferentiation in Cx32 (show GJB1 Proteins)-deficient mice
Ceramide production in M-CSF (show CSF1R Proteins)-deprived macrophages arises from a combination of ASMase (show SMPD1 Proteins) activity and de novo synthesis.
CSF-1 did not rescue the growth and lung defects associated with hyperoxia in this model; however, an increase in CSF-1R (show CSF1R Proteins)+ macrophages was not associated with an exacerbation of lung injury.
CSF-1 neutralization led to a relatively uniform reduction in all inflammatory cell populations; GM-CSF (show CSF2 Proteins) neutralization resulted in the preferential loss among the monocyte/macrophage populations.
The results of this study indicated that the CSF1 overexpression observed in CNS pathologies likely has pleiotropic influences on microglia.
FoxO1 (show FOXO1 Proteins) is highly expressed in M-CSF (show CSF1R Proteins)-derived (M2-like) macrophage subsets, and this M2-like macrophages showed a preferential FoxO1 (show FOXO1 Proteins) enrichment on the IL-10 (show IL10 Proteins) promoter but not in GM-CSF (show CSF2 Proteins)-derived (M1-like) macrophages
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants.
macrophage colony-stimulating factor 1
, colony stimulating factor 1 (macrophage)
, macrophage colony-stimulating factor 1-like
, colony-stimulating factor 1