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|Application / Reactivity||Human|
|Cytometry by Time of Flight (CyTOF)||2 Antibodies|
|ELISA (Detection)||1 Antibodies|
|Enzyme Immunoassay (EIA)||4 Antibodies|
|Flow Cytometry (FACS)||97 Antibodies|
|Functional Studies (Func)||2 Antibodies|
|Immunochromatography (IC)||2 Antibodies|
|Immunocytochemistry (ICC)||13 Antibodies|
|Immunofluorescence (IF)||38 Antibodies|
|Immunofluorescence (Cultured Cells) (IF (cc))||13 Antibodies|
|Immunofluorescence (fixed cells) (IF/ICC)||2 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||16 Antibodies|
|Immunohistochemistry (IHC)||86 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||50 Antibodies|
|Immunoprecipitation (IP)||4 Antibodies|
|Intracellular Flow Cytometry (ICFC)||2 Antibodies|
|Neutralization (Neut)||2 Antibodies|
|Antigen||Colony Stimulating Factor 1 Receptor (CSF1R) Antibodies|
|Conjugate||This CSF1R antibody is un-conjugated Alternatives|
Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)
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Product Details anti-CSF1R AntibodyTarget Details CSF1R Application Details Handling Images
Binds to epitope aa 349-512.
Cellular Localization:Cell membrane. Mol. Wt. of Antigen: 130-150 kDa Does not react with Mouse and Cat.
|Characteristics||Synonyms: CSF-1-R, Fms proto-oncogene, c-fms, CSF1R, FMS, Macrophage colony-stimulating factor 1receptor|
|Purification||IgG purified from ascites fluid by ammonium sulfate precipitation|
|Immunogen||v-ras-transformed rat NRK cells expressing transduced human CSF-1R|
Target Details CSF1RProduct Details anti-CSF1R Antibody Application Details Handling Images back to top
|Alternative Name||CD115 (CSF1R Antibody Abstract)|
|Background||CD115, also known as c-fms, macrophage Colony Stimulating Factor Receptor (M-CSFR), or CSF-1R, exists in immature (gp130c-fms) and mature (gp150c-fms) forms. CSF-1R exhibits an intrinsic tyrosine-specific protein kinase activity. It is expressed on the cells of the mononuclear phagocyte lineage. CSF-1R is an integral transmembrane glycoprotein consisting of a 512 amino acid extracellular domain that includes the CSF-1 binding site, a single 25 amino acid membrane-spanning segment, and a 435 amino acid cytoplasmic portion that includes the tyrosine kinase domain.Synonyms: CSF-1-R, CSF1R, FMS, Fms proto-oncogene, Macrophage colony-stimulating factor 1 receptor, c-fms|
|Research Area||CD Antigens, Surface Receptors of Immune Cells|
|Pathways||RTK Signaling, Inositol Metabolic Process, Cell-Cell Junction Organization|
Application DetailsProduct Details anti-CSF1R Antibody Target Details CSF1R Handling Images back to top
Blocks Ligand Binding, Blocks Ligand-dependent Proliferation and inhibitsCSF-1-independend Growth of Cells Expressing Mutant CSF-1R (see Ref.2, use azide freeantibody ABIN180374). Also useful for Immunofluorescence (see Ref.1) andImmunohistology (Acetone-fixed frozen sections). Positive Control: Tonsil.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CSF1R Antibody Target Details CSF1R Application Details Images back to top
|Buffer||10 mM PBS, pH 7.4, with 0.2 % BSA and 0.09 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
Store at 2-8 °C for up to one month or in aliquots at -20 °C for longer. Avoid repeated freezethaw cycles!
Shelf life: one year from despatch.
|Expiry Date||12 months|