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|Application / Reactivity||Human|
|Blocking Reagent (BR)||1 Antibodies|
|Enzyme Immunoassay (EIA)||4 Antibodies|
|Flow Cytometry (FACS)||38 Antibodies|
|Functional Studies (Func)||2 Antibodies|
|Immunochromatography (IC)||2 Antibodies|
|Immunocytochemistry (ICC)||11 Antibodies|
|Immunofluorescence (IF)||35 Antibodies|
|Immunofluorescence (Cultured Cells) (IF (cc))||11 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||13 Antibodies|
|Immunohistochemistry (IHC)||63 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||22 Antibodies|
|Immunoprecipitation (IP)||1 Antibodies|
|Intracellular Flow Cytometry (ICFC)||2 Antibodies|
|Neutralization (Neut)||2 Antibodies|
|Proximity Ligation Assay (PLA)||2 Antibodies|
|Western Blotting (WB)||173 Antibodies|
|Antigen||Colony Stimulating Factor 1 Receptor (CSF1R) Antibodies|
|Conjugate||This CSF1R antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-CSF1R AntibodyTarget Details CSF1R Application Details Handling References for anti-CSF1R Antibody (ABIN359787) Images
|Specificity||This antiobdy reacts to MCSF Receptor (CSF1R).|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CSF1R.|
Target Details CSF1RProduct Details anti-CSF1R Antibody Application Details Handling References for anti-CSF1R Antibody (ABIN359787) Images back to top
|Alternative Name||CD115 (CSF1R Antibody Abstract)|
|Background||CSF1R is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. This protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Synonyms: CSF-1-R, CSF1R, FMS, Fms proto-oncogene, Macrophage colony-stimulating factor 1 receptor, c-fms|
|Gene ID||1436, 9606|
|Research Area||CD Antigens, Surface Receptors of Immune Cells|
Application DetailsProduct Details anti-CSF1R Antibody Target Details CSF1R Handling References for anti-CSF1R Antibody (ABIN359787) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immumnohistochemistry: 1/50 - 1/100. Flow cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CSF1R Antibody Target Details CSF1R Application Details References for anti-CSF1R Antibody (ABIN359787) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-CSF1R Antibody (ABIN359787)Product Details anti-CSF1R Antibody Target Details CSF1R Application Details Handling Images back to top
Follows, Tagoh, Lefevre et al.: "Epigenetic consequences of AML1-ETO action at the human c-FMS locus." in: The EMBO journal, Vol. 22, Issue 11, pp. 2798-809, 2003 (PubMed).
Riccioni, Saulle, Militi et al.: "C-fms expression correlates with monocytic differentiation in PML-RAR alpha+ acute promyelocytic leukemia." in: Leukemia, Vol. 17, Issue 1, pp. 98-113, 2003 (PubMed).
Ide, Seligson, Memarzadeh et al.: "Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 22, pp. 14404-9, 2002 (PubMed).
Zhu, Gläser, Mrowietz: "Vitamin D(3) and analogues modulate the expression of CSF-1 and its receptor in human dendritic cells." in: Biochemical and biophysical research communications, Vol. 297, Issue 5, pp. 1211-7, 2002 (PubMed).
Flick, Sapi, Kacinski: "Hormonal regulation of the c-fms proto-oncogene in breast cancer cells is mediated by a composite glucocorticoid response element." in: Journal of cellular biochemistry, Vol. 85, Issue 1, pp. 10-23, 2002 (PubMed).
ImagesProduct Details anti-CSF1R Antibody Target Details CSF1R Application Details Handling References for anti-CSF1R Antibody (ABIN359787) back to top