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|Application / Reactivity||Mouse (Murine)|
|ELISA (Detection)||2 Antibodies|
|Enzyme Immunoassay (EIA)||3 Antibodies|
|Flow Cytometry (FACS)||56 Antibodies|
|Functional Studies (Func)||8 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||4 Antibodies|
|Immunofluorescence (IF)||12 Antibodies|
|Immunofluorescence (Cultured Cells) (IF (cc))||11 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||12 Antibodies|
|Immunohistochemistry (IHC)||41 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||8 Antibodies|
|Immunoprecipitation (IP)||2 Antibodies|
|Intracellular Flow Cytometry (ICFC)||1 Antibodies|
|Mass Cytometry (CyTOF)||2 Antibodies|
|Western Blotting (WB)||83 Antibodies|
|Antigen||Colony Stimulating Factor 1 Receptor (CSF1R) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This CSF1R antibody is conjugated to APC Alternatives|
Flow Cytometry (FACS), Mass Cytometry (CyTOF)
|7 references available|
|Supplier||Log in to see|
Product Details anti-CSF1R AntibodyTarget Details CSF1R Application Details Handling References for anti-CSF1R Antibody (ABIN2658444) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.|
Target Details CSF1RProduct Details anti-CSF1R Antibody Application Details Handling References for anti-CSF1R Antibody (ABIN2658444) Images back to top
|Alternative Name||CD115 (CSF1R Antibody Abstract)|
|Background||CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.|
|Research Area||CD Antigens, Surface Receptors of Immune Cells|
Application DetailsProduct Details anti-CSF1R Antibody Target Details CSF1R Handling References for anti-CSF1R Antibody (ABIN2658444) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-CSF1R Antibody Target Details CSF1R Application Details References for anti-CSF1R Antibody (ABIN2658444) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-CSF1R Antibody (ABIN2658444)Product Details anti-CSF1R Antibody Target Details CSF1R Application Details Handling Images back to top
Svahn, Grahnemo, Pálsdóttir et al.: "Dietary polyunsaturated fatty acids increase survival and decrease bacterial load during septic Staphylococcus aureus infection and improve neutrophil function in mice." in: Infection and immunity, Vol. 83, Issue 2, pp. 514-21, 2015 (PubMed).
Sauter, Pridans, Sehgal et al.: "Pleiotropic effects of extended blockade of CSF1R signaling in adult mice." in: Journal of leukocyte biology, Vol. 96, Issue 2, pp. 265-74, 2014 (PubMed).
Jaeger, Donadieu, Cognet et al.: "Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis." in: The Journal of experimental medicine, Vol. 209, Issue 3, pp. 565-80, 2012 (PubMed).
Yu, Chen, Xiong et al.: "CSF-1 receptor structure/function in MacCsf1r-/- macrophages: regulation of proliferation, differentiation, and morphology." in: Journal of leukocyte biology, Vol. 84, Issue 3, pp. 852-63, 2008 (PubMed).
Goswami, Sahai, Wyckoff et al.: "Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop." in: Cancer research, Vol. 65, Issue 12, pp. 5278-83, 2005 (PubMed).
Murayama, Yokode, Kataoka et al.: "Intraperitoneal administration of anti-c-fms monoclonal antibody prevents initial events of atherogenesis but does not reduce the size of advanced lesions in apolipoprotein E-deficient mice." in: Circulation, Vol. 99, Issue 13, pp. 1740-6, 1999 (PubMed).
Sudo, Nishikawa, Ogawa et al.: "Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M." in: Oncogene, Vol. 11, Issue 12, pp. 2469-76, 1996 (PubMed).
ImagesProduct Details anti-CSF1R Antibody Target Details CSF1R Application Details Handling References for anti-CSF1R Antibody (ABIN2658444) back to top