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Browse our DDR1 Proteins (DDR1)

Full name:
Discoidin Domain Receptor tyrosine Kinase 1 Proteins (DDR1)
On www.antibodies-online.com are 19 Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) Proteins from 5 different suppliers available. Additionally we are shipping DDR1 Antibodies (146) and DDR1 Kits (10) and many more products for this protein. A total of 189 DDR1 products are currently listed.
Synonyms:
6030432F18, AI323681, CAK, CD167, CD167a, CG9488, CG9490, CG11573, CG13984, CG13985, CG33531, CT33540, DDR, Dmel\\CG33531, Dmel_CG13984, Drd1, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, PTK3D, RTK6, TRKE
list all proteins Gene Name GeneID UniProt
DDR1 12305 Q03146
DDR1 780 Q08345
DDR1 25678  

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DDR1 Proteins (DDR1) by Origin

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Top referenced DDR1 Proteins

  1. Human DDR1 Protein expressed in Baculovirus infected Insect Cells - ABIN2003317 : Abdulhussein, McFadden, Fuentes-Prior, Vogel: Exploring the collagen-binding site of the DDR1 tyrosine kinase receptor. in The Journal of biological chemistry 2004 (PubMed)
    Show all 3 references for ABIN2003317

  2. Rat (Rattus) DDR1 Protein expressed in Human Cells - ABIN2009624 : Wang, Yeh, Tang: DDR1/E-cadherin complex regulates the activation of DDR1 and cell spreading. in American journal of physiology. Cell physiology 2009 (PubMed)
    Show all 3 references for ABIN2009624

  3. Human DDR1 Protein expressed in Human Cells - ABIN2003315 : Flynn, Blissett, Calomeni, Agarwal: Inhibition of collagen fibrillogenesis by cells expressing soluble extracellular domains of DDR1 and DDR2. in Journal of molecular biology 2010 (PubMed)
    Show all 3 references for ABIN2003315

More Proteins for DDR1 Interaction Partners

Mouse (Murine) Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) interaction partners

  1. DDR-1 interacts with the TGF-beta (show TGFB1 Proteins) pathway to restrict calcifying extracellular vesicle-mediated mineralization and fibrosis by smooth muscle cells.

  2. alpha5(IV), but not alpha1(IV), promotes lung cancer cell proliferation and tumor angiogenesis through non-integrin collagen receptor (show ITGA2 Proteins) DDR1-mediated ERK (show EPHB2 Proteins) activation.

  3. DDR1 malfunction causes outer hair cells deformation and the separation of the lateral wall, the location of the cellular motor responsible for the electromotile property, explicitly in those regions showing DDR1 and NM-IIA co-localization.

  4. the collagen receptors DDR1 and integrin a2b1 contribute to regulate GBM-maturation and to control matrix accumulation.

  5. Extensive co-localization and relationship of Jag1 (show JAG1 Proteins) and Ddr1 in bile ducts and blood vessels in postnatal liver.

  6. Genetic inhibition of discoidin domain receptor 1 protects mice against crescentic glomerulonephritis.

  7. Data identifyies Syk (show SYK Proteins) as a potent inhibitor of epithelial migration and describes a first functional consequence of the interaction with the collagen receptor (show ITGA2 Proteins) DDR1.

  8. Results show that DDR1 promotes cell-cell adhesion and differentiation through stabilization of E-cadherin (show CDH1 Proteins), which is mediated by Cdc42 (show CDC42 Proteins) inactivation.

  9. Collagen I stimulates the self-renewal of embryonic stem cells mediated by Bmi-1 (show BMI1 Proteins) through alpha2beta1 integrin-dependent ILK (show ILK Proteins), Notch (show NOTCH1 Proteins), Gli-1 (show GLI1 Proteins), and DDR1-dependent Ras, PI3K/Akt (show AKT1 Proteins), and ERK (show EPHB2 Proteins).

  10. Loss of Discoidin domain receptor 1 is associated with inflammation and fibrosis in obstructive nephropathy

Human Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) interaction partners

  1. Knockdown DDR1 reversed the effects of Galpha13 (show GNA13 Proteins) knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen.

  2. Data suggest SCl2 (Streptococcus pyogenes) binds to DDR (DDR1, DDR2 (show DDR2 Proteins)) ectodomain w/o stimulating receptor signaling; here, protein engineering was used to construct SCl (show KRT7 Proteins)-like proteins that inhibit collagen-DDR interactions and macrophage migration.

  3. DDR1 is a key modulator of RIT (show RIT1 Proteins) activity.

  4. DDR1 expression is a prognostic indicator in pancreatic ductal carcinoma.

  5. alpha5(IV), but not alpha1(IV), promotes lung cancer cell proliferation and tumor angiogenesis through non-integrin collagen receptor (show ITGA2 Proteins) DDR1-mediated ERK (show EPHB2 Proteins) activation.

  6. Hypoxia can increase DDR1 expression in pituitary adenoma cells, leading to improved MMP-2 (show MMP2 Proteins) and MMP-9 (show MMP9 Proteins) secretion, and promoting pituitary adenoma cell proliferation and invasion.

  7. suggest that DDR1 suppression may enhance adipose-derived stem cell chondrogenesis by enhancing the expression of chondrogenic genes and cartilaginous matrix deposition.

  8. MT1-MMP (show MMP14 Proteins)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells

  9. Defective Ca(2 (show CA2 Proteins)+) binding in a conserved binding site causes incomplete N-glycan processing and endoplasmic reticulum trapping of DDR1 and DDR2 (show DDR2 Proteins) receptors.

  10. A DDR1(Low)/DDR2 (show DDR2 Proteins)(High) protein profile is associated with TNBC and may identify invasive carcinomas with worse prognosis.

DDR1 Protein Profile

Protein Summary

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Alternative names and synonyms associated with DDR1

  • Discoidin domain receptor (Ddr)
  • discoidin domain receptor family, member 1 (Ddr1)
  • discoidin domain receptor tyrosine kinase 1 (DDR1)
  • discoidin domain receptor tyrosine kinase 1 (Ddr1)
  • 6030432F18 protein
  • AI323681 protein
  • CAK protein
  • CD167 protein
  • CD167a protein
  • CG9488 protein
  • CG9490 protein
  • CG11573 protein
  • CG13984 protein
  • CG13985 protein
  • CG33531 protein
  • CT33540 protein
  • DDR protein
  • Dmel\\CG33531 protein
  • Dmel_CG13984 protein
  • Drd1 protein
  • EDDR1 protein
  • HGK2 protein
  • MCK10 protein
  • NEP protein
  • NTRK4 protein
  • PTK3 protein
  • PTK3A protein
  • PTK3D protein
  • RTK6 protein
  • TRKE protein

Protein level used designations for DDR1

CG33531-PA , CG33531-PB , Ddr-PA , Ddr-PB , discoidin domain receptor , CD167 antigen-like family member A , cell adhesion kinase , discoidin receptor tyrosine kinase , epithelial discoidin domain receptor 1 , epithelial discoidin domain-containing receptor 1 , protein-tyrosine kinase MPK-6 , tyrosine kinase DDR , tyrosine-protein kinase CAK , PTK3A protein tyrosine kinase 3A , mammary carcinoma kinase 10 , neuroepithelial tyrosine kinase , neurotrophic tyrosine kinase, receptor, type 4 , protein-tyrosine kinase RTK-6 , discoidin domain receptor family, member 1 , neurotrophic tyrosine kinase receptor type 4 , protein-tyrosine kinase 3 , protein-tyrosine kinase PTK-3

GENE ID SPECIES
3346209 Drosophila melanogaster
12305 Mus musculus
780 Homo sapiens
25678 Rattus norvegicus
100144462 Sus scrofa
462548 Pan troglodytes
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