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|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||3 Antibodies|
|Flow Cytometry (FACS)||6 Antibodies|
|Immunocytochemistry (ICC)||4 Antibodies|
|Immunofluorescence (IF)||11 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||2 Antibodies|
|Immunohistochemistry (IHC)||18 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||11 Antibodies|
|Western Blotting (WB)||58 Antibodies|
|Antigen||Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) Antibodies|
|Conjugate||This DDR2 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|3 references available|
|Supplier||Log in to see|
Product Details anti-DDR2 AntibodyTarget Details DDR2 Application Details Handling References for anti-DDR2 Antibody (ABIN1105936) Images
|Specificity||Recognizes Human DDR2. Other species not tested.|
Target Details DDR2Product Details anti-DDR2 Antibody Application Details Handling References for anti-DDR2 Antibody (ABIN1105936) Images back to top
|Alternative Name||CD167b / DDR2 (DDR2 Antibody Abstract)|
|Background||DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.Synonyms: CD167 antigen-like family member B, Discoidin domain-containing receptor 2, Discoidin domain-containing receptor tyrosine kinase 2, NTRKR3, Neurotrophic tyrosine kinase receptor-related 3, Receptor protein-tyrosine kinase TKT, TKT, TYRO10, Tyrosine-protein kinase TYRO10|
Application DetailsProduct Details anti-DDR2 Antibody Target Details DDR2 Handling References for anti-DDR2 Antibody (ABIN1105936) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-DDR2 Antibody Target Details DDR2 Application Details References for anti-DDR2 Antibody (ABIN1105936) Images back to top
|Buffer||0.03 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
References for anti-DDR2 Antibody (ABIN1105936)Product Details anti-DDR2 Antibody Target Details DDR2 Application Details Handling Images back to top
Leitinger, Kwan: "The discoidin domain receptor DDR2 is a receptor for type X collagen." in: Matrix biology : journal of the International Society for Matrix Biology, Vol. 25, Issue 6, pp. 355-64, 2006 (PubMed).
Shyu, Chao, Wang et al.: "Regulation of discoidin domain receptor 2 by cyclic mechanical stretch in cultured rat vascular smooth muscle cells." in: Hypertension, Vol. 46, Issue 3, pp. 614-21, 2005 (PubMed).
Neale, Kenny, Gershwin: "Cloning and sequencing of protein kinase cDNA from harbor seal (Phoca vitulina) lymphocytes." in: Clinical & developmental immunology, Vol. 11, Issue 2, pp. 157-63, 2004 (PubMed).
ImagesProduct Details anti-DDR2 Antibody Target Details DDR2 Application Details Handling References for anti-DDR2 Antibody (ABIN1105936) back to top