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Findings demonstrated that mutant alpha2-chimaerin and EphA4 have different genetic interactions in distinct motor neuron pools: abducens neurons use bidirectional ephrin signaling via mutant alpha2-chimaerin to direct growth, while cervical spinal neurons use only ephrin forward signaling
The present study demonstrates that EphA4 and EphA7 (show EPHA7 ELISA Kits) receptors, despite their similar structure, have distinct in vivo effects on corticothalamic system projections into the ventrobasal complex /medial division of the posterior nuclear group.
These results suggest that EphA4, a novel and promising target for treatment, exacerbates EBI (show TBL1X ELISA Kits) through an Ephexin-1 (show NGEF ELISA Kits)/ROCK2 (show ROCK2 ELISA Kits) pathway after subarachnoid hemorrhage.
Our studies show that forward signaling through the EphA4 tyrosine kinase receptor (show KDR ELISA Kits), mediated by ephrins expressed by subpopulations of neuroblasts and astrocytes, is required for compact, directional organization of neuroblasts and astrocytes within the pathway and efficient transit of neuroblasts through the anterior forebrain to the olfactory bulb.
Findings suggest a putative novel mechanism for desipramine to modulate long-term potentiation through the regulation of the ephrinA3/EphA4 signaling pathway
Delineation of the specific mutation in EphA4 in this strain is important for further functional studies, such as protein-protein interactions, immunostaining and gene compensatory studies, investigating the mechanism underlying the effects of altered function of Eph (show EPHA1 ELISA Kits) family of receptor tyrosine kinases on phenotype.
the results of the present study demonstrated that angiogenesis occurs, and that the molecules EphA4 and ephrin-A5 (show EFNA5 ELISA Kits) are expressed in the hippocampal CA1 (show CA1 ELISA Kits) and CA3 (show CA3 ELISA Kits) areas throughout epileptogenesis. PECAM-1 (show PECAM1 ELISA Kits) may detect epileptic microvessel patterns in the hippocampi of mice and EphA4 may contribute to the microvessel plasticity via the ephrin-A5 (show EFNA5 ELISA Kits) signaling pathway.
results suggest that EphA4 is involved in circadian sleep regulation
The findings of this study revealed the behavioral and circuit-level impact of conditional EphA4 mutation in a transcriptionally defined spinal interneuron subpopulation.
Data show the effects of genetic loss of ephrin-A5, Eph receptors EphA4, and EphA7 on the development of medulloblastoma tumors in the smoothened (Smo) transgenic mouse model.
Molecular interactions of EphA4, growth hormone receptor (show GHR ELISA Kits), Jak2 (show JAK2 ELISA Kits), and STAT5B (show STAT5B ELISA Kits) have been described.
Reduced EphA4 expression is associated with EBV-associated B lymphoma.
No difference was found in the expression of EPHA4 in morphologically normal glands, HGPIN, or prostatic cancer.
we supposed that EphA4 interacted with CDK5 (show CDK5 ELISA Kits) and promoted its expression which in turn enhanced p-AKT (show AKT1 ELISA Kits) expression and promoted cell adhesion-mediated drug resistance in multiple myeloma.
EphA4 was reduced in breast carcinoma, which is associated with high grade, advanced TNM (show ODZ1 ELISA Kits) stage, lymph node metastasis, and poor outcome of patients
Host EphA4 expression regulates cancer development mainly via EphA4-mediated IGF1 (show IGF1 ELISA Kits) synthesis signal.
EPHA4 is overexpressed but not functionally active in Sezary syndrome.
The signaling complex appears to integrate the input from FGFR (show FGFR2 ELISA Kits) and EphA4, and release the output signal through FRS2alpha (show FRS2 ELISA Kits).
EphA4 induced accumulation of amyloid precursor protein (show APP ELISA Kits) through a Lyn (show LYN ELISA Kits)-mediated pathway.
expression of Eph (show EPHA1 ELISA Kits) A1, A2, A4, and A7 was strongly detected in endometrial epithelial cells during early pregnancy.
The EphA4 gene is significantly associated with litter size in pigs.
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
ephrin receptor epsilon
, EPH receptor A4
, ephrin receptor EphA4
, ephrin type-A receptor 4
, ephrin receptor EphA4-like
, ephrin type-A receptor 4-like
, tyrosine-protein kinase receptor MPK-3
, tyrosine-protein kinase receptor SEK-1
, EPH-like kinase 8
, TYRO1 protein tyrosine kinase
, receptor protein-tyrosine kinase HEK8
, tyrosine-protein kinase TYRO1
, tyrosine-protein kinase receptor SEK