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anti-Mouse (Murine) EPH Receptor B4 antibody for Enzyme Immunoassay

Recommended EPH Receptor B4 Antibody (supplied by: Log in to see )

Antigen
EPH Receptor B4 (EPHB4) Antibodies
  • AI042935
  • ephB4a
  • ephb4b
  • HTK
  • htk
  • Htk
  • MDK2
  • MGC130997
  • MYK1
  • Myk1
  • myk1
  • TYRO11
  • tyro11
  • Tyro11
Reactivity
Mouse (Murine)
129
50
9
1
1
1
1
1
1
1
Host
Rat
66
66
16
12
Clonality
Monoclonal
Conjugate
This EPH Receptor B4 antibody is un-conjugated
6
6
6
4
4
4
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
115
97
26
21
19
14
4
4
2
2
1
1
Supplier
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Catalog No. ABIN1107116
$ 643.50
Plus shipping costs $45.00

Top referenced anti-EPH Receptor B4 antibody for Enzyme Immunoassay

Similar anti-EPH Receptor B4 Antibodies

Application / Reactivity Mouse (Murine)
ELISA 29 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies
Flow Cytometry (FACS) 5 Antibodies
Immunoassay (IA) 2 Antibodies
Immunocytochemistry (ICC) 2 Antibodies
Immunofluorescence (IF) 7 Antibodies
Immunohistochemistry (IHC) 8 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 3 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 4 Antibodies
Western Blotting (WB) 43 Antibodies

General

Antigen EPH Receptor B4 (EPHB4) Antibodies
Reactivity Mouse (Murine)
(129), (50), (9), (1), (1), (1), (1), (1), (1), (1)
Host Rat
(66), (66), (16), (12)
Clonality (Clone)
Monoclonal   ( )
Conjugate This EPH Receptor B4 antibody is un-conjugated
(6), (6), (6), (4), (4), (4), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
(115), (97), (26), (21), (19), (14), (4), (4), (2), (2), (1), (1)
Pubmed 1 reference available
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Product Details anti-EPH Receptor B4 Antibody

Target Details EPH Receptor B4 Application Details Handling References for anti-EPH Receptor B4 Antibody (ABIN1107116) Images
Cross-Reactivity (Details) Species reactivity (tested):Mouse
Purification Purified
Clone VEB4-7E4
Isotype IgG2a

Target Details EPH Receptor B4

Product Details anti-EPH Receptor B4 Antibody Application Details Handling References for anti-EPH Receptor B4 Antibody (ABIN1107116) Images back to top
Antigen
Alternative Name EPHB4 (EPHB4 Antibody Abstract)
Background Erythropoietin-producing human hepatocellular carcinoma (Eph) receptors and ephrins are membrane proteins. They are classified into 2 broad subclasses, namely A and B, according to structural homologies and binding specificities. Eph receptors are tyrosine kinases, which autophosphorylate upon binding to their cognate ephrin ligands. Eph receptors and ephrins are frequently expressed in reciprocal patterns that correlate with cellular boundaries during embryonic development. The interaction between EphB4 and its ligand, Ephrin-B2, plays an important role in cell-cell, cell-extracellular matrix interactions as well as in cell migration, adhesion and proliferation. During the early stages of vascular development, EphB4 is specifically expressed in venous endothelium, whereas Ephrin-B2 is expressed in arterial endothelium. In mouse embryo's, EphB4 and Ephrin-B2 are essential for embryonic heart development and angiogenesis. In adult microcirculation, EphB4 is not a ubiquitous marker of arterial/venous polarity, but is expressed along both venules and arterioles. Furthermore, EphB4 is upregulated by endothelial cells along blind-ended capillary sprouts versus connecting capillaries. As such, EphB4 is thought to play a role in the patterning of new vessels during angiogenesis. EphB4 is also expressed in a variety of tumor cells, like gastrointestinal, prostate, bladder, breast, liver, lung and ovarian cancers, as well as leukemia, mesothelioma, malignant breast tumors and melanoma. Reduction of EphB4 activity accelerated tumorigenesis in colon and rectum. In head and neck squamous cell carcinoma and endometrial carcinoma, overexpression of EphB4 is inversely related to a poor prognosis. However, in mesothelioma, up-regulation of EphB4 resulted in growth of the tumor. Besides the essential expression of EphB4, coexpression of other EphB4 family members or EphB-ligands may affect tumor cell viability and proliferation as well.Synonyms: Ephrin type-B receptor 4, HTK, TYRO11, Tyrosine-protein kinase TYRO11, Tyrosine-protein kinase receptor HTK
Gene ID 13846
NCBI Accession NP_034274
UniProt P54761
Pathways RTK Signaling

Application Details

Product Details anti-EPH Receptor B4 Antibody Target Details EPH Receptor B4 Handling References for anti-EPH Receptor B4 Antibody (ABIN1107116) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-EPH Receptor B4 Antibody Target Details EPH Receptor B4 Application Details References for anti-EPH Receptor B4 Antibody (ABIN1107116) Images back to top
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.

References for anti-EPH Receptor B4 Antibody (ABIN1107116)

Product Details anti-EPH Receptor B4 Antibody Target Details EPH Receptor B4 Application Details Handling Images back to top
Background publications

Huang, Yamada, Kidoya, Naito, Nagahama, Kong, Katoh, Li, Ueno, Takakura: "EphB4 overexpression in B16 melanoma cells affects arterial-venous patterning in tumor angiogenesis." in: Cancer research, Vol. 67, Issue 20, pp. 9800-8, 2007