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Human Epiregulin Protein expressed in Escherichia coli (E. coli) - ABIN2666803
Morita, Shirakata, Shiraishi, Kadota, Hashimoto, Higashiyama, Ohashi: Human corneal epithelial cell proliferation by epiregulin and its cross-induction by other EGF family members. in Molecular vision 2007
Show all 7 references for ABIN2666803
Mouse (Murine) Epiregulin Protein expressed in Escherichia coli (E. coli) - ABIN2666805
Yoshikawa, Kojima, Yaguchi, Okada, Saito, Moriyama: Cholesteatoma fibroblasts promote epithelial cell proliferation through overexpression of epiregulin. in PLoS ONE 2013
Show all 7 references for ABIN2666805
Human Epiregulin Protein expressed in Human Cells - ABIN2003203
Toyoda, Komurasaki, Uchida, Morimoto: Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family. in The Biochemical journal 1997
Show all 3 references for ABIN2003203
Mouse (Murine) Epiregulin Protein expressed in Human Cells - ABIN2008047
Sato, Nakamura, Mizuguchi, Miura, Tada, Aizawa, Gomi, Miyamoto, Kawano: Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity. in FEBS letters 2003
Show all 3 references for ABIN2008047
EREG and AREG (show AREG Proteins) are strongly regulated by methylation, and their expression is associated with CIMP status and primary tumour site.
three-dimensional structure of the EPR antibody (the 9E5(Fab (show FANCB Proteins)) fragment) in the presence and absence of EPR
Together, these studies lead to identification of a novel pathway involving EREG and MMP-1 (show MMP1 Proteins) that contributes to the formation of early stage breast cancer
These results suggested that EREG is one of the molecules involved in glioma malignancy
Data indicate that the effects of epiregulin (EREG) and V-ATPase (show ATP6V1H Proteins) (TCIRG1 (show TCIRG1 Proteins)) single nucleotide polymorphism (SNP) on pulmonary tuberculosis susceptibility, to the extent that they exist, are dependent on gene-gene interactions in West African populations.
Patients homozygous for the minor allele A of EREG rs12641042 had a significantly higher 3-year survival rate than patients with allele C (HR 0.48; P=0.034), but significance was lost in multivariable analysis
Epiregulin is a transcriptional target of TSC2 (tuberin).
Epiregulin promotes the proliferation of liver progenitor cells and DNA synthesis by hepatocytes and is upregulated in the serum of patients with liver injury.
Plasma HGF and EREG levels are associated with resistance to treatment with anti-EGFR antibodies in KRAS wild-type patients with metastatic colorectal cancer.
Data suggest that EREG (epiregulin), AREG (amphiregulin (show AREG Proteins)), and BTC (betacellulin (show BTC Proteins)) induced prostaglandin E2 production by induction of COX-2 (prostaglandin-endoperoxide synthase 2 (show PTGS2 Proteins)) through MAP kinase (show MAPK1 Proteins) signaling in granulosa cells.
Pre-maturation with cAMP modulators in conjunction with EGF (show EGF Proteins)-like peptides during in vitro maturation enhances mouse oocyte developmental competence.
EREG and tumor-associated fibroblasts play a crucial role in controlling tumor growth in colitis-associated neoplasms.
Epiregulin can effectively mature isolated cumulus-oocyte complexes, but fails as a substitute for the hCG (show CGA Proteins)/epidermal growth factor (show EGF Proteins) stimulus on cultured follicles.
This study implicates that EREG mediates signals downstream of Areg (show AREG Proteins) mRNA expression and that EGFR (show EGFR Proteins)-ERBB2 (show ERBB2 Proteins) signals contributes to regulation of ovulation process.
A TLR-->MyD88 (show MYD88 Proteins)-->AREG (show AREG Proteins)/EREG-->EGFR (show EGFR Proteins) signaling pathway is represented in nonhematopoietic cells of the intestinal tract, responds to microbial stimuli once barriers are breached, and mediates protection against dextran sulfate sodium-induced colitis.
epidermal growth factor (EGF (show EGF Proteins)) family members amphiregulin (show AREG Proteins), epiregulin, and beta-cellulin are paracrine mediators that propagate the LH signal throughout the ovulatory follicle
Epiregulin plays a critical role in immune/inflammatory-related responses of keratinocytes and macrophages.
Data suggest that epiregulin (Ereg) deficiency does not alter intestinal cancer susceptibility, but that Ereg-null mice are highly susceptible to cancer-predisposing intestinal damage caused by oral dextran sulfate sodium.
Epiregulin is a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors.