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anti-Mouse (Murine) ERBB4 Antibodies:
anti-Rat (Rattus) ERBB4 Antibodies:
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Human Polyclonal ERBB4 Primary Antibody for IF, IHC (p) - ABIN389572
Prickett, Agrawal, Wei, Yates, Lin, Wunderlich, Cronin, Cruz, Rosenberg, Samuels: Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. in Nature genetics 2009
Show all 2 Pubmed References
Human Polyclonal ERBB4 Primary Antibody for IHC (p), WB - ABIN391950
Cheng, Tikhomirov, Zhou, Carpenter: Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment. in The Journal of biological chemistry 2003
Show all 4 Pubmed References
Human Monoclonal ERBB4 Primary Antibody for FACS, ICC - ABIN267015
Kawata, Morikawa, Shiosaka, Tamura: Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation. in Translational psychiatry 2017
Human Monoclonal ERBB4 Primary Antibody for CyTOF, FACS - ABIN251106
Saglam, Xiong, Marchion, Strosberg, Wenham, Johnson, Saeed-Vafa, Cubitt, Hakam, Magliocco: ERBB4 Expression in Ovarian Serous Carcinoma Resistant to Platinum-Based Therapy. in Cancer control : journal of the Moffitt Cancer Center 2017
Human Polyclonal ERBB4 Primary Antibody for ICC, IF - ABIN443062
Hsu, Yang, Lin, Tseng, Lin: The significance of Her2 on androgen receptor protein stability in the transition of androgen requirement in prostate cancer cells. in American journal of physiology. Endocrinology and metabolism 2011
Human Polyclonal ERBB4 Primary Antibody for FACS, IF (p) - ABIN737436
Zhao: Expression and Localization of Neuregulin-1 (Nrg1) and ErbB2/ErbB4 Receptors in Main Endocrine Organs of the Rhesus Monkey. in International journal of endocrinology and metabolism 2013
Human Polyclonal ERBB4 Primary Antibody for IHC (p) - ABIN2473486
Jones: Physiologic emboli changes observed during total hip replacement arthroplasty. A clinical prospective study. in Clinical orthopaedics and related research 1976
Show all 2 Pubmed References
Human Monoclonal ERBB4 Primary Antibody for CyTOF, FACS - ABIN4899977
Khelwatty, Essapen, Seddon, Modjtahedi: Growth response of human colorectal tumour cell lines to treatment with afatinib (BIBW2992), an irreversible erbB family blocker, and its association with expression of HER family members. in International journal of oncology 2011
Human Monoclonal ERBB4 Primary Antibody for FACS - ABIN4897003
Richards, Zweidler-McKay, Van Roy, Speleman, Trevino, Zage, Hughes: Signaling of ERBB receptor tyrosine kinases promotes neuroblastoma growth in vitro and in vivo. in Cancer 2010
Human Polyclonal ERBB4 Primary Antibody for CyTOF, FACS - ABIN4899978
Kastin, Akerstrom, Pan: Neuregulin-1-beta1 enters brain and spinal cord by receptor-mediated transport. in Journal of neurochemistry 2004
the NRG-ErbB4 signaling pathway can potentially influence many functional systems throughout the brain of primates, and suggest that major sites of action are areas of the "corticolimbic" network
Widespread expression of ErbB4 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization, with higher levels in grey matter compared to white matter.
ErbB (show EGFR Antibodies) signaling control both convergent extension and head mesoderm migration during gastrulation.
we show that the antifibrotic effect of neuregulin-1 (show NRG1 Antibodies) is at least partially mediated through anti-inflammatory activity, linked to receptor tyrosine-protein kinase erbB-4 activation in macrophages
These results suggest that the neuropsin (show KLK8 Antibodies)-NRG1 (show NRG1 Antibodies) signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin (show PVALB Antibodies)-expressing interneurons, and that neuropsin (show KLK8 Antibodies) regulates E/I balance and gamma oscillations through NRG1 (show NRG1 Antibodies)-ErbB4 signaling toward parvalbumin (show PVALB Antibodies)-expressing interneurons.
findings reveal molecular, cellular, and circuit mechanisms of NRG1 (show NRG1 Antibodies)/ErbB4 in regulating the initiation of critical period visual cortical plasticity.
To our knowledge, this is the first evidence that ErbB4 signaling in the MSNs is involved in the pathology of schizophrenia.
opposing signals generated by different ErbB (show EGFR Antibodies) dimer combinations function in the same cardiac cushion mesenchymal cells for proper cardiac valve formation.
Study revealed that bed nucleus of the stria terminalis NRG1 (show NRG1 Antibodies)-ErbB4 signaling is involved in regulating anxiety, and that blocking this pathway produced anxiety-like behavior.
Parallel microarray profiling identifies Erbb4 as a marker of cyst growth in autosomal dominant polycystic kidney disease and as a prognostic marker for disease progression.
a suppressor of miR (show MLXIP Antibodies)-146a, suggesting an autocrine loop. Inhibition of ErbB4/EGFR (show EGFR Antibodies) with erlotinib co-treatment of podocytes suppressed this signaling. Findings suggest a novel role for miR (show MLXIP Antibodies)-146a in protecting against diabetic glomerulopathy and podocyte injury.
the disruption of NRG1 (show NRG1 Antibodies)-ErbB4 signaling in the parvalbumin (show PVALB Antibodies) interneurons mediated by neuroinflammation might lead to abnormal gamma oscillations and thus contribute to cognitive impairment in a mouse model of SAE
the cleavage of ErbB4 by calpain contributes to a neuronal cell death cascade during brain ischemia.
High ERBB4 expression is associated with Merkel cell carcinoma
High ERBB4 expression is associated with colon cancer metastasis.
ERBB4 mutation is associated with Metaplastic Breast Cancer.
Results show higher expression levels of ErbB4 and KITENIN (show Vangl1 Antibodies) in stage IV colorectal cancer tissues resulting in elevated phosphorylated level of ERBB2 (show ERBB2 Antibodies).
We directly link TDP-43 (show TARDBP Antibodies) loss of function toxicity to two genes with rare amyotrophic lateral sclerosis and frontotemporal lobar degeneration-causing mutations, CHMP2B (show CHMP2B Antibodies) and ErbB4
Differential expression patterns of EGF (show EGF Antibodies), EGFR (show EGFR Antibodies), and ERBB4 are essential in epithelial restitution and remodeling in nasal epithelium.
There were significant differences in human epidermal growth factor receptor (show EGFR Antibodies) 2 and human epidermal growth factor receptor (show EGFR Antibodies) 3 serum levels between the patients with tissue human epidermal growth factor receptor (show EGFR Antibodies) 2-positive and tissue human epidermal growth factor receptor (show EGFR Antibodies) 2-negative ( p = 0.0026, p = 0.000011) tumors, but not in the serum levels of human epidermal growth factor receptor (show EGFR Antibodies) 4 ( p = 0.054).
the HER4 G1109C mutation is an activating oncogenic mutation with a transformational ability and that afatinib was effective against an HER4 G1109C-mutated HNSCC cell line by inhibiting the HER4 signal, both in vitro and in vivo.
identified a novel Her4-induced posttranslational modification on MDMX (show MDM4 Antibodies)
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
, receptor tyrosine-protein kinase erbB-4
, v-erb-a erythroblastic leukemia viral oncogene homolog 4
, receptor tyrosine-protein kinase erbB-4-like
, receptor tyrosine kinase ErbB4
, receptor tyrosine-protein kinase ErbB-4
, ovarian receptor tyrosine kinase erbB4 precusor
, receptor tyrosine kinase
, avian erythroblastosis oncogene B 4
, proto-oncogene-like protein c-ErbB-4
, avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4
, tyrosine kinase-type cell surface receptor HER4