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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Immunofluorescence (fixed cells) (IF/ICC)||5 Antibodies||4 Antibodies||4 Antibodies|
|Cytometry by Time of Flight (CyTOF)||2 Antibodies||1 Antibodies|
|Western Blotting (WB)||202 Antibodies||75 Antibodies||48 Antibodies|
|Neutralization (Neut)||1 Antibodies|
|Immunoprecipitation (IP)||22 Antibodies||15 Antibodies||13 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||85 Antibodies||48 Antibodies||27 Antibodies|
|Immunohistochemistry (IHC)||139 Antibodies||43 Antibodies||27 Antibodies|
|Antigen||V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) Antibodies|
|Epitope||AA 35-51, N-Term Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This ERBB4 antibody is un-conjugated Alternatives|
Western Blotting (WB)
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Product Details anti-ERBB4 AntibodyTarget Details ERBB4 Application Details Handling Images
|Purpose||Rabbit IgG polyclonal antibody for Receptor tyrosine-protein kinase erbB-4(ERBB4) detection. Tested with WB in Human,Mouse,Rat.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Receptor tyrosine-protein kinase erbB-4(ERBB4) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: v-erb-a erythroblastic leukemia viral oncogene homolog 4(avian)
Protein Name: Receptor tyrosine-protein kinase erbB-4
|Purification||Immunogen affinity purified.|
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human ErbB 4(35-51aa KLSSLSDLEQQYRALRK), identical to the related rat and mouse sequences.|
Target Details ERBB4Product Details anti-ERBB4 Antibody Application Details Handling Images back to top
|Alternative Name||ERBB4 (ERBB4 Antibody Abstract)|
ERBB4(V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) also known as ONCOGENE ERBB4 or HER4, is an enzyme that in humans is encoded by the ERBB4 gene. The HER4/ERBB4 gene is a member of the type I receptor tyrosine kinase subfamily that includes EGFR, ERBB2 and ERBB3. The ERBB4 gene is mapped on 2q34. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domainbinding motif. Huang et al.(2000) reported that ERBB4 is enriched in the postsynaptic density and associates with PSD95. ERBB4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding its ligand, heregulin, or activation of protein kinase C by TPA, the ERBB4 ectodomain is cleaved by a metalloprotease. Ni et al.(2001)concluded that gamma-secretase cleavage of ERBB4 may represent another mechanism for receptor tyrosine kinase-mediated signaling.
Synonyms: 4ICD antibody|Avian erythroblastic leukemia viral oncogene homolog 4 antibody|Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4 antibody|E4ICD antibody|EC 220.127.116.11 antibody|ErbB4 antibody|ERBB4 intracellular domain antibody|ERBB4_HUMAN antibody|HER 4 antibody|HER4 antibody|Mer4 antibody|MGC138404 antibody|Oncogene ERBB4 antibody|P180erbB4 antibody|Proto-oncogene-like protein c-ErbB-4 antibody|Receptor protein tyrosine kinase erbB 4 precursor antibody|Receptor tyrosine protein kinase erbB 4 antibody|s80HER4 antibody|Tyrosine kinase type cell surface receptor HER4 antibody|Tyrosine kinase-type cell surface receptor HER4 antibody|v erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody|v erb a erythroblastic leukemia viral oncogene homolog 4 antibody|v-erb-a erythroblastic leukemia viral oncogene homolog 4(avian) antibody|V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4 antibody|Verba avian erythroblastic leukemia viral oncogene homolog like 4 antibody|Verba erythroblastic leukemia viral oncogene homolog 4 antibody|VERBB2 antibody
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-ERBB4 Antibody Target Details ERBB4 Handling Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for ERBB4 is approximately 0.5 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
|Restrictions||For Research Use only|
HandlingProduct Details anti-ERBB4 Antibody Target Details ERBB4 Application Details Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.|
|Preservative||Thimerosal (Merthiolate), Sodium azide|
|Precaution of Use||This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
|Expiry Date||12 months|
ImagesProduct Details anti-ERBB4 Antibody Target Details ERBB4 Application Details Handling back to top