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Browse our ERBB4 Proteins (ERBB4)

Full name:
V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) Proteins (ERBB4)
On www.antibodies-online.com are 32 V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) Proteins from 10 different suppliers available. Additionally we are shipping ERBB4 Antibodies (354) and ERBB4 Kits (7) and many more products for this protein. A total of 412 ERBB4 products are currently listed.
Synonyms:
c-erbB-4, erbb4, HER4, p180erbB4, si:ch211-227n20.1
list all proteins Gene Name GeneID UniProt
ERBB4 13869 Q61527
ERBB4 59323 Q62956
ERBB4 2066 Q15303

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ERBB4 Proteins (ERBB4) by Origin

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Top referenced ERBB4 Proteins

  1. Human ERBB4 Protein expressed in Baculovirus infected Insect Cells - ABIN2002680 : Vidal, Clark, Marrero, Jones: A constitutively active ERBB4/HER4 allele with enhanced transcriptional coactivation and cell-killing activities. in Oncogene 2007 (PubMed)
    Show all 6 references for ABIN2002680

  2. Human ERBB4 Protein expressed in Human Cells - ABIN2002678 : Elenius, Paul, Allison, Sun, Klagsbrun: Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. in The EMBO journal 1997 (PubMed)
    Show all 6 references for ABIN2002678

  3. Mouse (Murine) ERBB4 Protein expressed in Human Cells - ABIN2008557 : Vidal, Naresh, Marrero, Jones: Presenilin-dependent gamma-secretase processing regulates multiple ERBB4/HER4 activities. in The Journal of biological chemistry 2005 (PubMed)
    Show all 6 references for ABIN2008557

  4. Rat (Rattus) ERBB4 Protein expressed in Human Cells - ABIN2009198 : Carpenter: ErbB-4: mechanism of action and biology. in Experimental cell research 2003 (PubMed)
    Show all 5 references for ABIN2009198

  5. Human ERBB4 Protein expressed in HEK-293 Cells - ABIN2181044 : Garcia, Vasudevan, Buonanno: The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
    Show all 2 references for ABIN2181044

More Proteins for ERBB4 Interaction Partners

Rhesus Monkey V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) interaction partners

  1. the NRG-ErbB4 signaling pathway can potentially influence many functional systems throughout the brain of primates, and suggest that major sites of action are areas of the "corticolimbic" network

  2. Widespread expression of ErbB4 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization, with higher levels in grey matter compared to white matter.

Xenopus laevis V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) interaction partners

  1. ErbB (show EGFR Proteins) signaling control both convergent extension and head mesoderm migration during gastrulation.

Mouse (Murine) V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) interaction partners

  1. A combination of miRNAs induced via endothelial coculture improved embryonic-stem-cell-derived cardiomyocytes maturity, in part through suppression of ErbB4 signaling.

  2. The expression of ERBB3 (show ERBB3 Proteins) in combination with ERBB4 significantly amplifies proliferation of lymphocytes upon ligand stimulation.

  3. These results suggest a mechanism by which cross-talk between DISC1 (show DISC1 Proteins) and NRG1 (show NRG1 Proteins)-ErbB4 signalling may contribute to these deficits.

  4. Findings reveal an intimate reciprocal relationship between ErbB4 and GluN2b (show GRIN2B Proteins) NMDA receptors via NRG2 (show NRG2 Proteins)/ErbB4 signaling.

  5. ERBB4 overexpression potentiates Mesenchymal stem cell survival in the infarcted heart, enhances NRG1 (show NRG1 Proteins) generation to restore the declining NRG1 (show NRG1 Proteins) in the infarcted region and stimulates cardiomyocyte division.

  6. The observations of this study indicated that NRG1 (show NRG1 Proteins)-ErbB4 signaling is critical to maintaining GABAergic activity in the amygdala and thus to modulating anxiety-like behaviors.

  7. Study shows that Cdk5 (show CDK5 Proteins) and its activator p35 (show CDK5R1 Proteins) control the tangential migration of interneurons toward and within the cerebral cortex by modulating the critical neurodevelopmental signaling pathway, ErbB4/phosphatidylinositol 3-kinase

  8. Although ERBB4 is dispensable for naive ERBB2 (show ERBB2 Proteins)+ breast cancer cells, it may play a key role in the survival of ERBB2 (show ERBB2 Proteins)+ cancer cells after they develop resistance to ERBB2 (show ERBB2 Proteins) inhibitors, lapatinib and trastuzumab.

  9. In the current study, we demonstrated that ErbB4 deletion in cpk mice, a murine autosomal recessive polycystic kidney disease model, promoted cyst formation and accelerated renal function decline.

  10. the ErbB4 receptor tyrosine kinase promotes seminiferous tubule development by controlling Sertoli cell and germ cell adhesion

Human V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) interaction partners

  1. The connections of EGFR (show EGFR Proteins) and ERBB4 signaling with SREBP-2 (show SREBF2 Proteins)-regulated cholesterol metabolism are likely to be important in ERBB (show EGFR Proteins)-regulated developmental processes and may contribute to metabolic remodeling in ERBB (show EGFR Proteins)-driven cancers.

  2. nuclear HER4 seem to be co-located with estrogen receptors, however, we did not find support for overall HER4 expression in independently predicting response of tamoxifen treatment in breast cancer

  3. while transcript and protein levels of EGFR (show EGFR Proteins) and ErbB2 (show ERBB2 Proteins) were up-regulated or unaffected, respectively, hepatitis c virus induced a substantial reduction of ErbB3 (show ERBB3 Proteins) and ErbB4 expression.

  4. the presence of activating driver mutations of ERBB4 in non-small cell lung cancer

  5. A combination of miRNAs induced via endothelial coculture improved embryonic-stem-cell-derived cardiomyocytes maturity, in part through suppression of ErbB4 signaling.

  6. NRG1 (show NRG1 Proteins) promotes the proliferation and migration of coronary artery smooth muscle cells by enhancing the phosphorylation of ErbB2 (show ERBB2 Proteins), ErbB3 (show ERBB3 Proteins) and ErbB4.

  7. Identification of a new subclass of ALK-negative Anaplastic large-cell lymphoma characterized by aberrant expression of ERBB4-truncated transcripts carrying intronic 5' untranslated regions.

  8. In this study, we developed an anti-ErbB4 mAb (clone P6-1) that suppresses NRG-dependent activation of ErbB4 and examined its effect on breast cancer cell proliferation in the extracellular matrix.

  9. Dysregulated ErbB4splicing in schizophreniamay contribute to lower activity of parvalbumin (show PVALB Proteins) interneurons and an activity-dependent down-regulation of parvalbumin (show PVALB Proteins) expression.

  10. NRG4 (show NRG4 Proteins) and its receptor ErbB4 are present in human breast milk and developing human intestine, respectively. Thus, NRG4 (show NRG4 Proteins)-ErbB4 signaling may be a novel pathway for therapeutic intervention or prevention in NEC.

ERBB4 Protein Profile

Protein Summary

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.

Alternative names and synonyms associated with ERBB4

  • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4)
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4a (avian) (erbb4a)
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (erbb4)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 (erbb4)
  • receptor tyrosine-protein kinase ErbB-4 (Tsp_13582)
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4)
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (Erbb4)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene 4 (Erbb4)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 (ERBB4)
  • c-erbB-4 protein
  • erbb4 protein
  • HER4 protein
  • p180erbB4 protein
  • si:ch211-227n20.1 protein

Protein level used designations for ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) , erbb4c , receptor tyrosine-protein kinase erbB-4 , v-erb-a erythroblastic leukemia viral oncogene homolog 4 , receptor tyrosine-protein kinase erbB-4-like , receptor tyrosine kinase ErbB4 , receptor tyrosine-protein kinase ErbB-4 , ovarian receptor tyrosine kinase erbB4 precusor , receptor tyrosine kinase , avian erythroblastosis oncogene B 4 , proto-oncogene-like protein c-ErbB-4 , c-erbB-4 , avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4 , tyrosine kinase-type cell surface receptor HER4

GENE ID SPECIES
459919 Pan troglodytes
693341 Macaca mulatta
100077353 Ornithorhynchus anatinus
100007677 Danio rerio
100014865 Monodelphis domestica
100154104 Sus scrofa
100470612 Ailuropoda melanoleuca
100558986 Anolis carolinensis
100598496 Nomascus leucogenys
724070 Xenopus laevis
10900432 Trichinella spiralis
395671 Gallus gallus
13869 Mus musculus
488508 Canis lupus familiaris
100050182 Equus caballus
100009328 Oryctolagus cuniculus
59323 Rattus norvegicus
2066 Homo sapiens
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