Browse our ERBB4 Proteins (ERBB4)

Full name:
V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) Proteins (ERBB4)
On www.antibodies-online.com are 33 V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) Proteins from 11 different suppliers available. Additionally we are shipping ERBB4 Antibodies (393) and ERBB4 Kits (10) and many more products for this protein. A total of 457 ERBB4 products are currently listed.
Synonyms:
c-erbB-4, erbb4, HER4, p180erbB4, si:ch211-227n20.1
list all proteins Gene Name GeneID UniProt
ERBB4 13869 Q61527
ERBB4 59323 Q62956
ERBB4 2066 Q15303

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ERBB4 Proteins (ERBB4) by Origin

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Top referenced ERBB4 Proteins

  1. Human ERBB4 Protein expressed in Baculovirus infected Insect Cells - ABIN2002680 : Vidal, Clark, Marrero, Jones: A constitutively active ERBB4/HER4 allele with enhanced transcriptional coactivation and cell-killing activities. in Oncogene 2007 (PubMed)
    Show all 6 references for 2002680

  2. Mouse (Murine) ERBB4 Protein expressed in Human Cells - ABIN2008557 : Elenius, Paul, Allison, Sun, Klagsbrun: Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. in The EMBO journal 1997 (PubMed)
    Show all 6 references for 2008557

  3. Rat (Rattus) ERBB4 Protein expressed in Human Cells - ABIN2009196 : Vidal, Naresh, Marrero, Jones: Presenilin-dependent gamma-secretase processing regulates multiple ERBB4/HER4 activities. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 references for 2009196

  4. Human ERBB4 Protein expressed in Human Cells - ABIN2002676 : Carpenter: ErbB-4: mechanism of action and biology. in Experimental cell research 2003 (PubMed)
    Show all 5 references for 2002676

  5. Human ERBB4 Protein expressed in HEK-293 Cells - ABIN2181046 : Garcia, Vasudevan, Buonanno: The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
    Show all 2 references for 2181046

More Proteins for ERBB4 Interaction Partners

Rhesus Monkey V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) interaction partners

  1. the NRG-ErbB4 signaling pathway can potentially influence many functional systems throughout the brain of primates, and suggest that major sites of action are areas of the "corticolimbic" network

  2. Widespread expression of ErbB4 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization, with higher levels in grey matter compared to white matter.

Xenopus laevis V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) interaction partners

  1. ErbB (show EGFR Proteins) signaling control both convergent extension and head mesoderm migration during gastrulation.

Mouse (Murine) V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) interaction partners

  1. To our knowledge, this is the first evidence that ErbB4 signaling in the MSNs is involved in the pathology of schizophrenia.

  2. opposing signals generated by different ErbB (show EGFR Proteins) dimer combinations function in the same cardiac cushion mesenchymal cells for proper cardiac valve formation.

  3. Study revealed that bed nucleus of the stria terminalis NRG1 (show NRG1 Proteins)-ErbB4 signaling is involved in regulating anxiety, and that blocking this pathway produced anxiety-like behavior.

  4. Parallel microarray profiling identifies Erbb4 as a marker of cyst growth in autosomal dominant polycystic kidney disease and as a prognostic marker for disease progression.

  5. a suppressor of miR (show MLXIP Proteins)-146a, suggesting an autocrine loop. Inhibition of ErbB4/EGFR (show EGFR Proteins) with erlotinib co-treatment of podocytes suppressed this signaling. Findings suggest a novel role for miR (show MLXIP Proteins)-146a in protecting against diabetic glomerulopathy and podocyte injury.

  6. the disruption of NRG1 (show NRG1 Proteins)-ErbB4 signaling in the parvalbumin (show PVALB Proteins) interneurons mediated by neuroinflammation might lead to abnormal gamma oscillations and thus contribute to cognitive impairment in a mouse model of SAE

  7. the cleavage of ErbB4 by calpain contributes to a neuronal cell death cascade during brain ischemia.

  8. Elevated coexpression of KITENIN and ErbB4-CYT (show CYGB Proteins)-2 promotes the transition of colon adenoma to adenocarcinoma within an APC (show APC Proteins) loss-associated tumor microenvironment

  9. A combination of miRNAs induced via endothelial coculture improved embryonic-stem-cell-derived cardiomyocytes maturity, in part through suppression of ErbB4 signaling.

  10. The expression of ERBB3 (show ERBB3 Proteins) in combination with ERBB4 significantly amplifies proliferation of lymphocytes upon ligand stimulation.

Human V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) interaction partners

  1. We directly link TDP-43 (show TARDBP Proteins) loss of function toxicity to two genes with rare amyotrophic lateral sclerosis and frontotemporal lobar degeneration-causing mutations, CHMP2B (show CHMP2B Proteins) and ErbB4

  2. Differential expression patterns of EGF (show EGF Proteins), EGFR (show EGFR Proteins), and ERBB4 are essential in epithelial restitution and remodeling in nasal epithelium.

  3. Parallel microarray profiling identifies Erbb4 as a marker of cyst growth in autosomal dominant polycystic kidney disease and as a prognostic marker for disease progression.

  4. There were significant differences in human epidermal growth factor receptor (show EGFR Proteins) 2 and human epidermal growth factor receptor (show EGFR Proteins) 3 serum levels between the patients with tissue human epidermal growth factor receptor (show EGFR Proteins) 2-positive and tissue human epidermal growth factor receptor (show EGFR Proteins) 2-negative ( p = 0.0026, p = 0.000011) tumors, but not in the serum levels of human epidermal growth factor receptor (show EGFR Proteins) 4 ( p = 0.054).

  5. the HER4 G1109C mutation is an activating oncogenic mutation with a transformational ability and that afatinib was effective against an HER4 G1109C-mutated HNSCC cell line by inhibiting the HER4 signal, both in vitro and in vivo.

  6. identified a novel Her4-induced posttranslational modification on MDMX (show MDM4 Proteins)

  7. In this study, we aimed to investigate the association of ERBB4 rs707284 with the risk of Schizophrenia in an Iranian population. There was no association between the risk of Schizophrenia and rs707284.

  8. Meta-analysis identified a statistically significant association between ErbB4 SNP rs707284 and susceptibility to schizophrenia among Asian and Caucasian populations under allelic model and marginal associations under recessive and homozygous models. In addition, in Asian subgroup analysis, rs707284 was marginally associated with schizophrenia under the recessive model.

  9. Our results indicated that SNP rs11895168 C allele located in ErbB4 3'UTR was significantly associated with elevated breast cancer risk.

  10. Advanced bioinformatic analysis softwares were used to analyze the regulatory mechanism after ErbB4 gene mutation in terms of amino acid sequence, primary, secondary, and tertiary structure of the protein and upstream-downstream receptor/ligands. Mutation of the 19th and 113th amino acids at the carboxyl terminus of ErbB4 protein did not affect its biological nature, but its secondary structure changed

ERBB4 Protein Profile

Protein Summary

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.

Alternative names and synonyms associated with ERBB4

  • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4)
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4a (avian) (erbb4a)
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (erbb4)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 (erbb4)
  • receptor tyrosine-protein kinase ErbB-4 (Tsp_13582)
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4)
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (Erbb4)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene 4 (Erbb4)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 (ERBB4)
  • c-erbB-4 protein
  • erbb4 protein
  • HER4 protein
  • p180erbB4 protein
  • si:ch211-227n20.1 protein

Protein level used designations for ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) , erbb4c , receptor tyrosine-protein kinase erbB-4 , v-erb-a erythroblastic leukemia viral oncogene homolog 4 , receptor tyrosine-protein kinase erbB-4-like , receptor tyrosine kinase ErbB4 , receptor tyrosine-protein kinase ErbB-4 , ovarian receptor tyrosine kinase erbB4 precusor , receptor tyrosine kinase , avian erythroblastosis oncogene B 4 , proto-oncogene-like protein c-ErbB-4 , c-erbB-4 , avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4 , tyrosine kinase-type cell surface receptor HER4

GENE ID SPECIES
459919 Pan troglodytes
693341 Macaca mulatta
100077353 Ornithorhynchus anatinus
100007677 Danio rerio
100014865 Monodelphis domestica
100154104 Sus scrofa
100470612 Ailuropoda melanoleuca
100558986 Anolis carolinensis
100598496 Nomascus leucogenys
724070 Xenopus laevis
10900432 Trichinella spiralis
395671 Gallus gallus
13869 Mus musculus
488508 Canis lupus familiaris
100050182 Equus caballus
100009328 Oryctolagus cuniculus
59323 Rattus norvegicus
2066 Homo sapiens
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