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the NRG-ErbB4 signaling pathway can potentially influence many functional systems throughout the brain of primates, and suggest that major sites of action are areas of the "corticolimbic" network
Widespread expression of ErbB4 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization, with higher levels in grey matter compared to white matter.
ErbB (show EGFR Proteins) signaling control both convergent extension and head mesoderm migration during gastrulation.
findings reveal molecular, cellular, and circuit mechanisms of NRG1 (show NRG1 Proteins)/ErbB4 in regulating the initiation of critical period visual cortical plasticity.
To our knowledge, this is the first evidence that ErbB4 signaling in the MSNs is involved in the pathology of schizophrenia.
opposing signals generated by different ErbB (show EGFR Proteins) dimer combinations function in the same cardiac cushion mesenchymal cells for proper cardiac valve formation.
Study revealed that bed nucleus of the stria terminalis NRG1 (show NRG1 Proteins)-ErbB4 signaling is involved in regulating anxiety, and that blocking this pathway produced anxiety-like behavior.
Parallel microarray profiling identifies Erbb4 as a marker of cyst growth in autosomal dominant polycystic kidney disease and as a prognostic marker for disease progression.
a suppressor of miR (show MLXIP Proteins)-146a, suggesting an autocrine loop. Inhibition of ErbB4/EGFR (show EGFR Proteins) with erlotinib co-treatment of podocytes suppressed this signaling. Findings suggest a novel role for miR (show MLXIP Proteins)-146a in protecting against diabetic glomerulopathy and podocyte injury.
the disruption of NRG1 (show NRG1 Proteins)-ErbB4 signaling in the parvalbumin (show PVALB Proteins) interneurons mediated by neuroinflammation might lead to abnormal gamma oscillations and thus contribute to cognitive impairment in a mouse model of SAE
the cleavage of ErbB4 by calpain contributes to a neuronal cell death cascade during brain ischemia.
Elevated coexpression of KITENIN (show Vangl1 Proteins) and ErbB4-CYT (show CYGB Proteins)-2 promotes the transition of colon adenoma to adenocarcinoma within an APC (show APC Proteins) loss-associated tumor microenvironment
A combination of miRNAs induced via endothelial coculture improved embryonic-stem-cell-derived cardiomyocytes maturity, in part through suppression of ErbB4 signaling.
ERBB4 mutation is associated with Metaplastic Breast Cancer.
Results show higher expression levels of ErbB4 and KITENIN (show Vangl1 Proteins) in stage IV colorectal cancer tissues resulting in elevated phosphorylated level of ERBB2 (show ERBB2 Proteins).
We directly link TDP-43 (show TARDBP Proteins) loss of function toxicity to two genes with rare amyotrophic lateral sclerosis and frontotemporal lobar degeneration-causing mutations, CHMP2B (show CHMP2B Proteins) and ErbB4
Differential expression patterns of EGF (show EGF Proteins), EGFR (show EGFR Proteins), and ERBB4 are essential in epithelial restitution and remodeling in nasal epithelium.
There were significant differences in human epidermal growth factor receptor (show EGFR Proteins) 2 and human epidermal growth factor receptor (show EGFR Proteins) 3 serum levels between the patients with tissue human epidermal growth factor receptor (show EGFR Proteins) 2-positive and tissue human epidermal growth factor receptor (show EGFR Proteins) 2-negative ( p = 0.0026, p = 0.000011) tumors, but not in the serum levels of human epidermal growth factor receptor (show EGFR Proteins) 4 ( p = 0.054).
the HER4 G1109C mutation is an activating oncogenic mutation with a transformational ability and that afatinib was effective against an HER4 G1109C-mutated HNSCC cell line by inhibiting the HER4 signal, both in vitro and in vivo.
identified a novel Her4-induced posttranslational modification on MDMX (show MDM4 Proteins)
In this study, we aimed to investigate the association of ERBB4 rs707284 with the risk of Schizophrenia in an Iranian population. There was no association between the risk of Schizophrenia and rs707284.
Meta-analysis identified a statistically significant association between ErbB4 SNP rs707284 and susceptibility to schizophrenia among Asian and Caucasian populations under allelic model and marginal associations under recessive and homozygous models. In addition, in Asian subgroup analysis, rs707284 was marginally associated with schizophrenia under the recessive model.
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
, receptor tyrosine-protein kinase erbB-4
, v-erb-a erythroblastic leukemia viral oncogene homolog 4
, receptor tyrosine-protein kinase erbB-4-like
, receptor tyrosine kinase ErbB4
, receptor tyrosine-protein kinase ErbB-4
, ovarian receptor tyrosine kinase erbB4 precusor
, receptor tyrosine kinase
, avian erythroblastosis oncogene B 4
, proto-oncogene-like protein c-ErbB-4
, avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4
, tyrosine kinase-type cell surface receptor HER4