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Human FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN2666735
Bookout, de Groot, Owen, Lee, Gautron, Lawrence, Ding, Elmquist, Takahashi, Mangelsdorf, Kliewer: FGF21 regulates metabolism and circadian behavior by acting on the nervous system. in Nature medicine 2013
Show all 6 references for ABIN2666735
Mouse (Murine) FGF21 Protein expressed in Human Cells - ABIN2007779
Arner, Pettersson, Mitchell, Dunbar, Kharitonenkov, Rydén: FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity. in FEBS letters 2008
Show all 3 references for ABIN2007779
Human FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN2003596
Micanovic, Raches, Dunbar, Driver, Bina, Dickinson, Kharitonenkov: Different roles of N- and C- termini in the functional activity of FGF21. in Journal of cellular physiology 2009
Show all 2 references for ABIN2003596
Human FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN666738
Dostálová, Haluzíková, Haluzík: Fibroblast growth factor 21: a novel metabolic regulator with potential therapeutic properties in obesity/type 2 diabetes mellitus. in Physiological research / Academia Scientiarum Bohemoslovaca 2009
Show all 2 references for ABIN666738
Mouse (Murine) FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN1888798
Stone, Wanders, Orgeron, Cortez, Gettys: Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. in Diabetes 2014
Appropriate signaling of FGF21 to neonate is necessary to ensure optimal digestive and endocrine function in developing intestine.
the hepatokine IGFBP1 (show IGFBPI Proteins) is a critical liver-bone hormonal relay that promotes osteoclastogenesis and bone resorption as well as an essential mediator of FGF21-induced bone loss
This study identified fibroblast activation protein (FAP) as the enzyme that cleaves and inactivates human FGF21.
Human FGF-21 Is a Substrate of Fibroblast Activation Protein.
GDF-15 (show GDF15 Proteins) and FGF-21 are elevated in mitochondrial diseases
Among cardiac patients, FGF21 had a negative association with MPV, whereas FGF23 (show FGF23 Proteins) had a positive association.
FGF21 has a role in microvascular disease
Levels of FGF21 are not different in patients with and without LDLR (show LDLR Proteins) mutations, which suggests that decreased LDLR (show LDLR Proteins) expression does not have a negative effect on FGF21 levels.
Serum FGF21 was significantly increased in schizophrenia patients compared to controls.
FGF21 may play an important role in short-term metabolic homoeostasis
RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low.
liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and white adipose tissue.
MiR (show MLXIP Proteins)-577 inhibits pancreatic beta-cell function and survival by targeting fibroblast growth factor 21 (FGF-21)
sustained activation of mTORC1 signaling in skeletal muscle regulated whole-body metabolism through the induction of FGF21, which, over the long term, caused severe lipodystrophy
Data show that enhancing beta-klotho (KLB (show KLB Proteins)) expression in adipose may sensitize to endogenous fibroblast growth factor 21 (FGF21), thus representing a novel strategy to combat metabolic disease.
This study shows that lactate regulates Fgf21 expression through a NADH/NAD-independent pathway, but requires active p38-MAPK (show MAPK14 Proteins) (mitogen activated protein kinase (show MAPK1 Proteins)) signalling.
Mouse FGF-21, however, lacks the FAP (show FAP Proteins) cleavage site and is not cleaved by FAP (show FAP Proteins).
Fenofibrate could prevent type 1 diabetes-induced pathological and functional abnormalities of the heart by increasing FGF21 and up-regulating Sirt1 (show SIRT1 Proteins)-mediated autophagy.
FGF21 protects against high-fat diet induced inflammation and islet hyperplasia in pancreas.
We demonstrate that endogenous FGF21 is not essential for the maintenance of normoglycaemia upon protein and carbohydrate starvation
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
fibroblast growth factor 21