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Human FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN2666735
Bookout, de Groot, Owen, Lee, Gautron, Lawrence, Ding, Elmquist, Takahashi, Mangelsdorf, Kliewer: FGF21 regulates metabolism and circadian behavior by acting on the nervous system. in Nature medicine 2013
Show all 6 references for ABIN2666735
Mouse (Murine) FGF21 Protein expressed in Human Cells - ABIN2007779
Arner, Pettersson, Mitchell, Dunbar, Kharitonenkov, Rydén: FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity. in FEBS letters 2008
Show all 3 references for ABIN2007779
Human FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN2003596
Micanovic, Raches, Dunbar, Driver, Bina, Dickinson, Kharitonenkov: Different roles of N- and C- termini in the functional activity of FGF21. in Journal of cellular physiology 2009
Show all 2 references for ABIN2003596
Human FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN666738
Dostálová, Haluzíková, Haluzík: Fibroblast growth factor 21: a novel metabolic regulator with potential therapeutic properties in obesity/type 2 diabetes mellitus. in Physiological research / Academia Scientiarum Bohemoslovaca 2009
Show all 2 references for ABIN666738
Mouse (Murine) FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN1888798
Stone, Wanders, Orgeron, Cortez, Gettys: Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. in Diabetes 2014
miR (show MLXIP Proteins)-149 could negatively regulate the protein expression level of FGF-21.
As a biomarker for diabetes prediction, serum FGF21 appeared to be superior to other adipokines and, on its own, could be considered as an alternative to the oral glucose tolerance test.
Serum FGF21 rises significantly in humans with acute pancreatitis. The pancreas may be contributing to increased FGF21 levels following injury and FGF21 may play a role in the recovery process.
These findings reveal an iNKT cell-FGF21 axis that defines a new immune-mediated pathway that could be targeted for glycemic control and weight regulation.
have identified fibroblast activation protein (FAP) as the endopeptidase responsible for this site-specific cleavage of human FGF21 (hFGF21), and propose that inhibition of FAP may be a therapeutic strategy to increase endogenous levels of active FGF21.
NS5ATP6 reduces the promoter activity of FGF21. NS5ATP6 may regulate FGF21 expression via miR (show MLXIP Proteins)-577. NS5ATP6 regulates the intracellular triglyceride level via FGF21, and independently of SIRT1 (show SIRT1 Proteins) and SREBP1 (show SREBF1 Proteins).
Study provides Class III evidence that elevated S-FGF21 accurately distinguishes patients with mitochondrial myopathies from patients with other conditions, and FGF21 and GDF15 (show GDF15 Proteins) mitochondrial myopathy from other myopathies.
FGF21-PXR (show NR1I2 Proteins) signaling pathway may be involved in decreased hepatic CYP3A4 (show CYP3A4 Proteins) metabolic activity in Nonalcoholic fatty liver disease.
data show that AHR (show AHR Proteins) contributes to hepatic energy homeostasis, partly through the regulation of FGF21 expression and signaling.
Chronic stimulation of PPARalpha (show PPARA Proteins) may suppress the autophagy capacity in the liver as a result of reduced content of a number of autophagy-associated proteins independent of FGF21.
The present study shows that expression of the FGF21 gene is strongly up-regulated during the transition period; the up-regulation of FGF21 might play an important role in the adaptation of liver metabolism during early lactation in dairy cows such as in other species.
RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low.
liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and white adipose tissue.
the metabolic outcomes associated with elevated FGF21 depend on the nutritional context, differing according to whether the animal is in a state of under- or overfeeding.
These findings indicate that FGF21 is crucial for the fenofibrate-mediated improvement of whole body glucose metabolism in obese mice via the amelioration of WAT dysfunctions.
These new findings reveal that the FGF21-betaKlotho-FGFR1 signaling axis plays roles in maintaining phospholipid homeostasis and the dynamic functions of the lipid droplet, whereas protecting against ER stress, and suggest a potential link of phospholipid biosynthesis, lipid droplet dynamics, ER stress, and energy homeostasis in adipose tissue coordinated by this signaling axis.
CYP2A5 protects against the development of alcoholic fatty liver disease, and the PPARalpha-FGF21 axis contributes to the protective effects of CYP2A5 on alcoholic fatty liver disease.
Heme-Regulated eIF2alpha (show EIF2A Proteins) Kinase Modulates Hepatic FGF21 and Is Activated by PPARbeta (show PPARD Proteins)/delta Deficiency. Findings suggest that HRI (show EIF2AK1 Proteins) is a potential target for regulating hepatic FGF21 levels.
FGF21 promotes myoblast differentiation and serves as a switch of molecular transformation from anaerobic myofibers to aerobic myofibers via the FGF21-SIRT1 (show SIRT1 Proteins)-AMPK (show PRKAA1 Proteins)-PGC1alpha axis.
this study shows that FGF21 exerts an anti-inflammatory effect mainly via enhancing Nrf2 (show NFE2L2 Proteins)-mediated anti-oxidant capacity and suppressing NF-kappaB (show NFKB1 Proteins) signaling pathway
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
fibroblast growth factor 21