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Mouse (Murine) FGF21 Protein expressed in Human Cells - ABIN2007779
Arner, Pettersson, Mitchell, Dunbar, Kharitonenkov, Rydén: FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity. in FEBS letters 2008
Show all 3 Pubmed References
Mouse (Murine) FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN1888798
Stone, Wanders, Orgeron, Cortez, Gettys: Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. in Diabetes 2014
FGF21 has a role in promoting remyelination in the central nervous system
FGF21 genotypes may interact with dietary carbohydrate/fat intake on changes in central adiposity and body fat composition. A low-calorie, high-carbohydrate/low-fat diet was beneficial for overweight or obese individuals carrying the carbohydrate intake-decreasing allele of the FGF21 variant to improve body composition and abdominal obesity.
serum FGF19 and FGF21 and hepatic Klotho expression are inversely associated with hepatic damage in children with NAFLD
Higher vitamin D status, but not FGF21, was associated with greater postprandial glucose oxidation and improved insulin (show INS Proteins) sensitivity in metabolic syndrome.
dietary protein dilution promotes improved glucose homeostasis through an select nonessential amino acids insufficiency-induced liver NUPR1 (show NUPR1 Proteins)/FGF21 axis
In Japanese men, acute endurance exercise lowers serum FGF21 levels 24 h following exercise. The results suggest that acute endurance exercise modulates postprandial FGF21 metabolism regardless of age.
Higher circulating FGF21 levels were associated with a high mortality rate, but not cardiovascular events in patient with end-stage renal disease, suggesting that circulating FGF21 levels serve as a predictive marker for mortality in these subjects.
FGF21 is not critical for bone homeostasis or actions of PPARalpha (show PPARA Proteins) and PPARgamma (show PPARG Proteins).
miR (show MLXIP Proteins)-149 could negatively regulate the protein expression level of FGF-21.
As a biomarker for diabetes prediction, serum FGF21 appeared to be superior to other adipokines and, on its own, could be considered as an alternative to the oral glucose tolerance test.
The present study shows that expression of the FGF21 gene is strongly up-regulated during the transition period; the up-regulation of FGF21 might play an important role in the adaptation of liver metabolism during early lactation in dairy cows such as in other species.
RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low.
liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and white adipose tissue.
Data suggest that expression of Fgf21 in liver responds acutely to dietary protein intake; low-protein high-carbohydrate diet induces Fgf21 expression; high-protein low-carbohydrate diet reduces Fgf21 expression; Fgf21 expression/secretion in cultured hepatocytes appears to be controlled by glucose but not amino acids.
These findings reveal a previously unappreciated anti-inflammatory role for FGF21 in adipose tissue, but do not support that FGF21 is necessary for exercise-mediated anti-inflammatory effects.
our results reveal that ERRgamma (show ESRRG Proteins), induced via activation of the hepatic CB1 (show CNR1 Proteins) receptor, is a regulator of hepatic FGF21 gene expression and secretion.
OPA1 mutant mice are resistant to age- and diet-induced weight gain and insulin (show INS Proteins) resistance, by mechanisms that involve activation of endoplasmic reticulum stress and secretion of fibroblast growth factor 21 (FGF21) from skeletal muscle, resulting in increased metabolic rates and improved whole-body insulin (show INS Proteins) sensitivity.
inhibitor of mTORC1 to control hepatic insulin (show INS Proteins) action and maintain glucose homeostasis
the acute and chronic effects of FGF21 can be dissociated through adipose-dependent and -independent mechanisms.
pancreatic FGF21 is a digestive enzyme secretagogue.
These findings reveal an iNKT cell-FGF21 axis that defines a new immune-mediated pathway that could be targeted for glycemic control and weight regulation.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
fibroblast growth factor 21