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Human FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN2666735
Bookout, de Groot, Owen, Lee, Gautron, Lawrence, Ding, Elmquist, Takahashi, Mangelsdorf, Kliewer: FGF21 regulates metabolism and circadian behavior by acting on the nervous system. in Nature medicine 2013
Show all 6 references for ABIN2666735
Mouse (Murine) FGF21 Protein expressed in Human Cells - ABIN2007779
Arner, Pettersson, Mitchell, Dunbar, Kharitonenkov, Rydén: FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity. in FEBS letters 2008
Show all 3 references for ABIN2007779
Human FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN2003596
Micanovic, Raches, Dunbar, Driver, Bina, Dickinson, Kharitonenkov: Different roles of N- and C- termini in the functional activity of FGF21. in Journal of cellular physiology 2009
Show all 2 references for ABIN2003596
Human FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN666738
Dostálová, Haluzíková, Haluzík: Fibroblast growth factor 21: a novel metabolic regulator with potential therapeutic properties in obesity/type 2 diabetes mellitus. in Physiological research / Academia Scientiarum Bohemoslovaca 2009
Show all 2 references for ABIN666738
Mouse (Murine) FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN1888798
Stone, Wanders, Orgeron, Cortez, Gettys: Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. in Diabetes 2014
FGF21-PXR (show NR1I2 Proteins) signaling pathway may be involved in decreased hepatic CYP3A4 (show CYP3A4 Proteins) metabolic activity in Nonalcoholic fatty liver disease.
data show that AHR (show AHR Proteins) contributes to hepatic energy homeostasis, partly through the regulation of FGF21 expression and signaling.
Chronic stimulation of PPARalpha (show PPARA Proteins) may suppress the autophagy capacity in the liver as a result of reduced content of a number of autophagy-associated proteins independent of FGF21.
Study compared the diagnostic utility of GDF-15 (show GDF15 Proteins) with FGF-21 in an adult mitochondrial disease cohort. GDF-15 (show GDF15 Proteins) outperforms FGF-21 as an indicator of mitochondrial diseases. GDF-15 (show GDF15 Proteins) is generally indicative of inherited mitochondrial disease regardless of clinical phenotype, whereas FGF-21 seems to be more indicative of mitochondrial disease when muscle manifestations are present
The results suggest that increased circulating CK-18 (show KRT18 Proteins) and FGF-21 are associated with Nonalcoholic Fatty Liver Disease and may be used for initial assessment, but not enough
Plasma FGF21 concentrations are increased in prediabetic first-degree relatives of patients with type 2 diabetes mellitus and that there is a significant association between FGF21 and obesity and insulin (show INS Proteins) sensitivity.
This review will give a comprehensive understanding of the underlying role of FGF21 and its possible interaction with other molecules in Diabetic nephropathy
FGF21 is a novel surrogate diagnostic biomarker in initial stages of T2 Diabetic retinopathy (particularly with FGF21 values above 135.5pg/mL).
Accumulation of adipose tissue in the RS is related with the visceral adipose amount, KIM-1 (show HAVCR1 Proteins) and FGF-21 concentration increase in the blood serum.
The results showed that the FGF21 promoter contains three response elements for ATF4 (show ATF4 Proteins), suggesting that FGF21 is a sensitive target of ATF4 (show ATF4 Proteins).
RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low.
liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and white adipose tissue.
this study shows that FGF21 exerts an anti-inflammatory effect mainly via enhancing Nrf2 (show NFE2L2 Proteins)-mediated anti-oxidant capacity and suppressing NF-kappaB (show NFKB1 Proteins) signaling pathway
FGF21 corrects multiple metabolic parameters on NAFLD in vitro and in vivo by inducing autophagy.
these data reveal a previously unidentified role for FGF21 on bile acid metabolism and may be relevant to understand the effects of FGF21 analogs in clinical studies.
These results suggest for the first time that FF prevents the development of diabetic nephropathy via up-regulating FGF21 and stimulating PI3K/Akt (show AKT1 Proteins)/GSK-3b/Fyn (show FYN Proteins)-mediated activation of the Nrf2 (show NFE2L2 Proteins) pathway.
The requirement of fibroblast growth factor 21 for the metabolic actions of hepatic cJun (show JUN Proteins) NH2-terminal kinase provides a mechanism for metabolic regulation by the JNK (show MAPK8 Proteins)-signaling pathway in the liver.
These findings establish Rev-erbalpha (show NR1D1 Proteins) as a specific modulator of FGF21 signaling in adipose tissue.
the liver regulates carbohydrate intake through production of the hepatokine fibroblast growth factor 21 (FGF21), which markedly suppresses consumption of simple sugars, but not complex carbohydrates, proteins, or lipids.
FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
fibroblast growth factor 21