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Human FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN2666735
Bookout, de Groot, Owen, Lee, Gautron, Lawrence, Ding, Elmquist, Takahashi, Mangelsdorf, Kliewer: FGF21 regulates metabolism and circadian behavior by acting on the nervous system. in Nature medicine 2013
Show all 6 references for ABIN2666735
Mouse (Murine) FGF21 Protein expressed in Human Cells - ABIN2007779
Arner, Pettersson, Mitchell, Dunbar, Kharitonenkov, Rydén: FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity. in FEBS letters 2008
Show all 3 references for ABIN2007779
Human FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN2003596
Micanovic, Raches, Dunbar, Driver, Bina, Dickinson, Kharitonenkov: Different roles of N- and C- termini in the functional activity of FGF21. in Journal of cellular physiology 2009
Show all 2 references for ABIN2003596
Human FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN666738
Dostálová, Haluzíková, Haluzík: Fibroblast growth factor 21: a novel metabolic regulator with potential therapeutic properties in obesity/type 2 diabetes mellitus. in Physiological research / Academia Scientiarum Bohemoslovaca 2009
Show all 2 references for ABIN666738
Mouse (Murine) FGF21 Protein expressed in Escherichia coli (E. coli) - ABIN1888798
Stone, Wanders, Orgeron, Cortez, Gettys: Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. in Diabetes 2014
The results showed that the FGF21 promoter contains three response elements for ATF4 (show ATF4 Proteins), suggesting that FGF21 is a sensitive target of ATF4 (show ATF4 Proteins).
Serum FGF21 level was highest in obese children with the highest insulin (show INS Proteins) resistance or abnormal glucose tolerance.
The association observed between cord blood FGF21 and postnatal BMI may suggest a potential role during intrauterine life that may influence future metabolic imbalance.
Data suggest that, in patients with newly diagnosed type 2 diabetes, plasma FGF21 levels are up-regulated as compared to control subjects; elevated FGF21 levels are significantly decreased with treatment (here, treatment with metformin). This case-control study was conducted in China.
Results provide evidence that leptin (show LEP Proteins) regulates FGF21 expression.
FGF-21 might involve in the development and maintenance of atrial fibrosis in atrial fibrillation with rheumatic heart disease, and FGF-21 could be used as a novel biomarker to evaluate myocardial fibrosis in the future.
Appropriate signaling of FGF21 to neonate is necessary to ensure optimal digestive and endocrine function in developing intestine.
the hepatokine IGFBP1 (show IGFBPI Proteins) is a critical liver-bone hormonal relay that promotes osteoclastogenesis and bone resorption as well as an essential mediator of FGF21-induced bone loss
This study identified fibroblast activation protein (FAP) as the enzyme that cleaves and inactivates human FGF21.
Human FGF-21 Is a Substrate of Fibroblast Activation Protein.
RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low.
liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and white adipose tissue.
These results suggest for the first time that FF prevents the development of diabetic nephropathy via up-regulating FGF21 and stimulating PI3K/Akt (show AKT1 Proteins)/GSK-3b/Fyn (show FYN Proteins)-mediated activation of the Nrf2 (show NFE2L2 Proteins) pathway.
The requirement of fibroblast growth factor 21 for the metabolic actions of hepatic cJun (show JUN Proteins) NH2-terminal kinase provides a mechanism for metabolic regulation by the JNK (show MAPK8 Proteins)-signaling pathway in the liver.
These findings establish Rev-erbalpha (show NR1D1 Proteins) as a specific modulator of FGF21 signaling in adipose tissue.
the liver regulates carbohydrate intake through production of the hepatokine fibroblast growth factor 21 (FGF21), which markedly suppresses consumption of simple sugars, but not complex carbohydrates, proteins, or lipids.
FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys.
MiR (show MLXIP Proteins)-577 inhibits pancreatic beta-cell function and survival by targeting fibroblast growth factor 21 (FGF-21)
sustained activation of mTORC1 signaling in skeletal muscle regulated whole-body metabolism through the induction of FGF21, which, over the long term, caused severe lipodystrophy
Data show that enhancing beta-klotho (KLB (show KLB Proteins)) expression in adipose may sensitize to endogenous fibroblast growth factor 21 (FGF21), thus representing a novel strategy to combat metabolic disease.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
fibroblast growth factor 21