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|Application / Reactivity||Human|
|Blocking Antibody (Inhibition)||1 Antibodies|
|Enzyme Immunoassay (EIA)||4 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||6 Antibodies|
|Immunofluorescence (IF)||3 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||32 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||11 Antibodies|
|Immunoprecipitation (IP)||8 Antibodies|
|Neutralization (Neut)||1 Antibodies|
|Western Blotting (WB)||69 Antibodies|
|Antigen||Fibroblast Growth Factor 4 (FGF4) Antibodies|
|Conjugate||This FGF4 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-FGF4 AntibodyTarget Details FGF4 Application Details Handling References for anti-FGF4 Antibody (ABIN360661) Images
|Specificity||This antibody reacts to FGF4.|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human FGF4.|
Target Details FGF4Product Details anti-FGF4 Antibody Application Details Handling References for anti-FGF4 Antibody (ABIN360661) Images back to top
|Alternative Name||FGF4 (FGF4 Antibody Abstract)|
|Background||FGF4 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The gene for FGF4 was identified by its oncogenic transforming activity. The gene for FGF4 and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.Synonyms: Fibroblast growth factor 4, HST, HST-1, HSTF1, Heparin secretory-transforming protein, Heparin-binding growth factor 4, KS3, Transforming protein KS3|
|Gene ID||2249, 9606|
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-FGF4 Antibody Target Details FGF4 Handling References for anti-FGF4 Antibody (ABIN360661) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-FGF4 Antibody Target Details FGF4 Application Details References for anti-FGF4 Antibody (ABIN360661) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-FGF4 Antibody (ABIN360661)Product Details anti-FGF4 Antibody Target Details FGF4 Application Details Handling Images back to top
Lopez-Sanchez, Climent, Schoenwolf et al.: "Induction of cardiogenesis by Hensen's node and fibroblast growth factors." in: Cell and tissue research, Vol. 309, Issue 2, pp. 237-49, 2002 (PubMed).
Koh, Ohta, Nakamae et al.: "Differential effects of fibroblast growth factor-4, epidermal growth factor and transforming growth factor-beta1 on functional development of stromal layers in acute myeloid leukemia." in: Leukemia research, Vol. 26, Issue 10, pp. 933-8, 2002 (PubMed).
Sieuwerts, Martens, Dorssers et al.: "Differential effects of fibroblast growth factors on expression of genes of the plasminogen activator and insulin-like growth factor systems by human breast fibroblasts." in: Thrombosis and haemostasis, Vol. 87, Issue 4, pp. 674-83, 2002 (PubMed).
Yamamoto, Ochiya, Tamamushi et al.: "HST-1/FGF-4 gene activation induces spermatogenesis and prevents adriamycin-induced testicular toxicity." in: Oncogene, Vol. 21, Issue 6, pp. 899-908, 2002 (PubMed).
Galland, Stefanova, Lafage et al.: "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23." in: Cytogenetics and cell genetics, Vol. 60, Issue 2, pp. 114-6, 1992 (PubMed).
ImagesProduct Details anti-FGF4 Antibody Target Details FGF4 Application Details Handling References for anti-FGF4 Antibody (ABIN360661) back to top