Browse our anti-FGFR3 (FGFR3) Antibodies

Full name:
anti-Fibroblast Growth Factor Receptor 3 Antibodies (FGFR3)
On www.antibodies-online.com are 201 Fibroblast Growth Factor Receptor 3 (FGFR3) Antibodies from 28 different suppliers available. Additionally we are shipping FGFR3 Proteins (52) and FGFR3 Kits (25) and many more products for this protein. A total of 295 FGFR3 products are currently listed.
Synonyms:
ACH, CD333, CEK2, fc27h01, Fgfr-3, FGFR3, Flg-2, FR3, HBGFR, HSFGFR3EX, JTK4, LOC100034114, Mfr3, sam3, wu:fc27h01
list all antibodies Gene Name GeneID UniProt
FGFR3 2261 P22607
FGFR3 14184  
FGFR3 84489  

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anti-Human FGFR3 Antibodies:

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anti-Rat (Rattus) FGFR3 Antibodies:

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Top referenced anti-FGFR3 Antibodies

  1. Human Polyclonal FGFR3 Primary Antibody for EIA, IHC (p) - ABIN359858 : Sturla, Merrick, Burchill: FGFR3IIIS: a novel soluble FGFR3 spliced variant that modulates growth is frequently expressed in tumour cells. in British journal of cancer 2003 (PubMed)
    Show all 5 references for 359858

  2. Human Polyclonal FGFR3 Primary Antibody for IHC (p), WB - ABIN391969 : Lievens, Liboi et al.: The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) ... in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for 391969

  3. Human Polyclonal FGFR3 Primary Antibody for IHC, ELISA - ABIN1533273 : Shimizu, Ishikawa, Iwai, Ueki, Sugihara, Onishi, Kuninaka, Miyamoto, Toyama, Ijiri, Mori, Matsuzaki, Yaguchi, Nishio, Kawakami, Ikeda, Saya: Fibroblast growth factor-2 (Fgf2) is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma. in Molecular cancer research : MCR 2012 (PubMed)

  4. Hamster Polyclonal FGFR3 Primary Antibody for IHC (p), IHC - ABIN407668 : Lim, Yap, Lim, Goh, Ng: Identification of autocrine growth factors secreted by CHO cells for applications in single-cell cloning media. in Journal of proteome research 2013 (PubMed)

  5. Human Monoclonal FGFR3 Primary Antibody for FACS - ABIN4898542 : Chandesris, Soulier, Labaume, Crinquette, Repellini, Chemin, Malphettes, Fieschi, Asli, Uzunhan, Fermand, Bories, Arnulf: Detection and follow-up of fibroblast growth factor receptor 3 expression on bone marrow and circulating plasma cells by flow cytometry in patients with t(4;14) multiple myeloma. in British journal of haematology 2007 (PubMed)

More Antibodies against FGFR3 Interaction Partners

Human Fibroblast Growth Factor Receptor 3 (FGFR3) interaction partners

  1. Liposarcoma patients harboring FGFR1 (show FGFR1 Antibodies)/3 mutations experienced reduced overall survival.

  2. High FGFR3 expression is associated with bladder cancer.

  3. Study provides evidence of the significant oncogenic potential of the FGFR3-TACC3 (show TACC3 Antibodies) fusion protein. The presence of the TACC coiled-coil domain leads to increased and altered levels of FGFR3 activation, fusion protein phosphorylation, downstream signaling, cellular transformation, proliferation, and viability.

  4. we show that low dose of NVP-BGJ398 improves in vivo condyle growth and corrects dysmorphologies in Fgfr3(Y367C/+) mice, suggesting that postnatal treatment with NVP-BGJ398 mice might offer a new therapeutic strategy to improve mandible anomalies in achondroplasia (ACH), and others FGFR3-related disorders.

  5. FGFR3 mRNA missplicing in hepatocellular carcinoma (HCC (show FAM126A Antibodies)), contributes significantly to its malignant character.

  6. Mutations in FGFR3 gene is associated with tubular adenomas.

  7. High FGFR3 expression is associated with multiple myeloma.

  8. FGFR3 was predominantly mutated in infiltrative hepatocellular carcinoma (HCC (show FAM126A Antibodies)) compared to nodular HCC (show FAM126A Antibodies). FGFR3 protein expression was higher in mutated infiltrative HCC (show FAM126A Antibodies) compared to non-mutated infiltrative HCC (show FAM126A Antibodies) and nodular HCC (show FAM126A Antibodies). FGFR3 may be a candidate oncogene (show RAB1A Antibodies) in tumor progression.

  9. Our findings show that grade heterogeneity in urothelial carcinoma is characterized by increased MIB-1 labelling, and particularly in the FGFR3 mutant pathway, with homozygous deletions of CDKN2A (show CDKN2A Antibodies) in low- and high-grade areas

  10. We argue that routine use of molecular genomic tumour analysis in urothelial carcinoma may inform selection of patients for appropriate trials and we further investigate the potential of FGFR3 as a meaningful clinical target for this difficult disease

Mouse (Murine) Fibroblast Growth Factor Receptor 3 (FGFR3) interaction partners

  1. data suggest that FGF2 (show FGF2 Antibodies) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (show NR3C1 Antibodies) expression, an effect that is likely receptor mediated, albeit not by FGFR1 (show FGFR1 Antibodies), FGFR2 (show FGFR2 Antibodies), and FGFR3.

  2. we show that low dose of NVP-BGJ398 improves in vivo condyle growth and corrects dysmorphologies in Fgfr3(Y367C/+) mice, suggesting that postnatal treatment with NVP-BGJ398 mice might offer a new therapeutic strategy to improve mandible anomalies in achondroplasia (ACH), and others FGFR3-related disorders.

  3. Conditional Fgfr3 deletion in mice aggravated destabilization of medial meniscus (DMM (show COL2A1 Antibodies))-induced cartilage degeneration. FGFR-3 activation attenuated cartilage degeneration induced by DMM (show COL2A1 Antibodies) surgery and age.

  4. Using a mouse model of Thanatophoric Dysplasia Type II (TDII) we show that both HDAC6 (show HDAC6 Antibodies) deletion and treatment with the small molecule HDAC6 (show HDAC6 Antibodies) inhibitor tubacin reduced FGFR3 accumulation in the growth plate and improved endochondral bone growth

  5. This study reveals that chondrocyte FGFR3 is involved in the regulation of bone formation and bone remodeling by a paracrine mechanism.

  6. Results show that Fgfr3-deficient mice exhibit progressive osteoarthritis-like defects in temporomandibular Joint (TMJ) changes, indicating that FGFR3 signaling is critically involved in the maintenance of the structure integrity and function of TMJ articular cartilage during adult stage.

  7. loss of Fgfr3 function leads to the formation of chondroma-like lesions via downregulation of MEK (show MDK Antibodies)/ERK (show EPHB2 Antibodies) signaling and upregulation of IHH (show IHH Antibodies).

  8. A proliferation-independent and SOX9 (show SOX9 Antibodies)-dependent differentiation block is a key driving mechanism responsible for poor endochondral bone growth in achondroplasia disorders caused by mutations in FGFR3.

  9. This study showed constitutively active form of Fgfr3 to increase FGF signaling.

  10. FGFR3 induces degradation of Bmpr1a (show BMPR1A Antibodies) to regulate skeletal development.

Zebrafish Fibroblast Growth Factor Receptor 3 (FGFR3) interaction partners

Cow (Bovine) Fibroblast Growth Factor Receptor 3 (FGFR3) interaction partners

  1. The ectodomain of FGFR3 is proteolytically cleaved in response to ligand-induced receptor activation by FGF1, but unlike most regulated intramembrane proteolysis target proteins, it requires endocytosis and does not involve a metalloproteinase.

  2. Alterations in the expression of VEGF-A (show VEGFA Antibodies) and bFGF (show FGF2 Antibodies) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

  3. chondrodysplastic dwarfism in Japanese brown cattle is not caused by mutation in the FGFR3 gene

FGFR3 Antigen Profile

Antigen Summary

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Alternative names and synonyms associated with FGFR3

  • fibroblast growth factor receptor 3 (FGFR3) antibody
  • fibroblast growth factor receptor 3 (LOC100034114) antibody
  • FGF receptor 3 (fgfr3) antibody
  • fibroblast growth factor receptor 3 (Fgfr3) antibody
  • fibroblast growth factor receptor 3 (fgfr3) antibody
  • ACH antibody
  • CD333 antibody
  • CEK2 antibody
  • fc27h01 antibody
  • Fgfr-3 antibody
  • FGFR3 antibody
  • Flg-2 antibody
  • FR3 antibody
  • HBGFR antibody
  • HSFGFR3EX antibody
  • JTK4 antibody
  • LOC100034114 antibody
  • Mfr3 antibody
  • sam3 antibody
  • wu:fc27h01 antibody

Protein level used designations for FGFR3

fibroblast growth factor receptor 3 , FGFR-3 , fibroblast growth factor receptor 3 variant 4 , hydroxyaryl-protein kinase , tyrosine kinase JTK4 , heparin-binding growth factor receptor , fibroblast growth factor receptor 3-IIIc , tyrosine kinase (cek2) , tyrosine kinase receptor CEK2 , fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)

GENE ID SPECIES
461067 Pan troglodytes
554324 Ovis aries
712829 Macaca mulatta
100034114 Equus caballus
100141386 Felis catus
399347 Xenopus laevis
2261 Homo sapiens
14184 Mus musculus
84489 Rattus norvegicus
396515 Gallus gallus
100732948 Cavia porcellus
58129 Danio rerio
488808 Canis lupus familiaris
281769 Bos taurus
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