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|Antigen||Fibroblast Growth Factor Receptor 3 (FGFR3) Antibodies|
|Conjugate||This FGFR3 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-FGFR3 AntibodyTarget Details FGFR3 Application Details Handling References for anti-FGFR3 antibody (ABIN359858) Images
|Specificity||This antibody reacts to FGFR3.|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human FGFR3.|
Target Details FGFR3Product Details anti-FGFR3 Antibody Application Details Handling References for anti-FGFR3 antibody (ABIN359858) Images back to top
|Alternative Name||CD333 / FGFR3 (FGFR3 Antibody Abstract)|
|Background||FGFR3 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.Synonyms: FGFR-3, Fibroblast growth factor receptor 3, JTK4|
|Gene ID||2261, 9606|
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding|
Application DetailsProduct Details anti-FGFR3 Antibody Target Details FGFR3 Handling References for anti-FGFR3 antibody (ABIN359858) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-FGFR3 Antibody Target Details FGFR3 Application Details References for anti-FGFR3 antibody (ABIN359858) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-FGFR3 antibody (ABIN359858)Product Details anti-FGFR3 Antibody Target Details FGFR3 Application Details Handling Images back to top
Sturla, Merrick, Burchill: "FGFR3IIIS: a novel soluble FGFR3 spliced variant that modulates growth is frequently expressed in tumour cells." in: British journal of cancer, Vol. 89, Issue 7, pp. 1276-84, 2003
Lievens, Liboi et al.: "The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) ..." in: The Journal of biological chemistry, Vol. 278, Issue 19, pp. 17344-9, 2003
Reinhart, Eulert, Bill, Würzler, Phan The, Reuther: "[Typical features of craniofacial growth of the FGFR3-associated coronal synostosis syndrome (so-called Muenke craniosynostosis)]." in: Mund-, Kiefer- und Gesichtschirurgie : MKG, Vol. 7, Issue 3, pp. 132-7, 2003
Pehlivan, Ozkinay, Okutman, Coğulu, Ozcan, Cankaya, Ulgenalp: "Achondroplasia in Turkey is defined by recurrent G380R mutation of the FGFR3 gene." in: The Turkish journal of pediatrics, Vol. 45, Issue 2, pp. 99-101, 2003
Santra, Zhan, Tian, Barlogie, Shaughnessy: "A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript." in: Blood, Vol. 101, Issue 6, pp. 2374-6, 2003
ImagesProduct Details anti-FGFR3 Antibody Target Details FGFR3 Application Details Handling References for anti-FGFR3 antibody (ABIN359858) back to top