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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Western Blotting (WB)||77 Antibodies||26 Antibodies||17 Antibodies|
|Neutralization (Neut)||1 Antibodies|
|Immunoprecipitation (IP)||8 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||25 Antibodies||7 Antibodies||7 Antibodies|
|Immunohistochemistry (IHC)||53 Antibodies||22 Antibodies||13 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies||11 Antibodies||11 Antibodies|
|Immunofluorescence (IF)||3 Antibodies||1 Antibodies||1 Antibodies|
|Immunocytochemistry (ICC)||5 Antibodies|
|Antigen||Fibroblast Growth Factor Receptor 3 (FGFR3) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This FGFR3 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-FGFR3 AntibodyTarget Details FGFR3 Application Details Handling Images
|Specificity||This antibody detects endogenous levels of FGFR3 protein. (region surrounding Trp153)|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
|Purification||Affinity Chromatography using epitope-specific immunogen.|
Target Details FGFR3Product Details anti-FGFR3 Antibody Application Details Handling Images back to top
|Alternative Name||CD333 / FGFR3 (FGFR3 Antibody Abstract)|
|Background||Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors.These include the Flg receptor or FGFR-1, the Bek receptor (or FGFR-2), FGFR-3, FGFR- 4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligandbinding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human Bek (also designated K-sam) maps to chromosome 10q26 and is alternatively spliced to produce several isoforms. Heterogeneous mutations in Bek are associated with a range of craniosynostosis syndromes including Pfeiffer syndrome, Crouzon syndrome, Jackson-Weiss syndrome and Apert syndrome.Synonyms: FGFR-3, Fibroblast growth factor receptor 3, JTK4|
|Molecular Weight||approx. 95 kDa|
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-FGFR3 Antibody Target Details FGFR3 Handling Images back to top
ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-FGFR3 Antibody Target Details FGFR3 Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
ImagesProduct Details anti-FGFR3 Antibody Target Details FGFR3 Application Details Handling back to top