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sFlt-1 overexpression in Padi4 (show PADI4 Proteins)(-/-) mice resulted in dramatically lower inflammatory and thrombotic response, which was accompanied by significant reduction in pregnancy losses. Inhibition of NETosis may serve as a novel target in disorders of impaired placentation.
endothelial dysfunction due to high circulating sFLT1 may be the primary event leading to enhanced vasoconstrictor sensitivity that is characteristic of preeclampsia
Flt1 has a role in blood vessel anastomosis during angiogenesis
First-in-class selective PET tracers for imaging VEGFR-1 and VEGFR-2 (show KDR Proteins) were constructed and successfully validated in an orthotopic murine tumor model.
these results suggest that VEGFR1 signaling plays a role in regulating the balance between macrophage phenotypes in streptozotocin -induced diabetic wounds, prevents impaired diabetic wound healing, and promotes angiogenesis/lymphangiogenesis.
These data therefore support a tightly controlled, paracrine signaling mechanism of VEGF-B (show VEGFB Proteins) to VEGFR1.
Flt1/VEGF-A (show VEGFA Proteins) signalling has stage-specific effects on vascular morphogenesis.
IL-35 treatment reduced collagen-induced arthritis via inhibiting vascular endothelial growth factor and its receptors
the VEGFR-1 tyrosine kinase (show TYRO3 Proteins) signaling has an effect on angiogenesis.
data suggest that sFlt-1 may have a therapeutic effect on AS, resulting from suppression of VEGF signaling-mediated recruitment of circulating monocytes/macrophages
this study found no difference in VEGFR1 expression in infantile hemangiomas from the study and control group
MiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA (show VEGFA Proteins), VEGFR1, VEGFR2 (show KDR Proteins), HGF (show HGF Proteins) and MMP2 (show MMP2 Proteins)
The SNPs rs9554322, rs9582036 and rs9943922 were correlated with age-related macular degeneration (AMD (show AMD1 Proteins)). Gene variants in VEGFR1 were linked to a pronounced emerging risk for AMD (show AMD1 Proteins) in a population in northern China.
Leptin (show LEP Proteins)-induced transphosphorylation of vascular endothelial growth factor receptor (show RYK Proteins) increases Notch (show NOTCH1 Proteins) and stimulates endothelial cell angiogenic transformation
The study aimed to assess the usefulness of the determination of cytokines: IL-8 (show IL8 Proteins), VEGF (show VEGFA Proteins) and its soluble receptors: VEGF (show VEGFA Proteins)-R1, VEGF (show VEGFA Proteins)-R2 in patients with endometrial cancer. The concentrations of IL-8 (show IL8 Proteins), VEGF (show VEGFA Proteins), VEGFR1 and CA 125 (show MUC16 Proteins) allowed to distinguish patients for the control group.
Gestational diabetes mellitus is associated with reduced expression of Flt-1 mRNA and protein.
Structure of the full-length VEGFR-1 extracellular domain in complex with VEGF-A (show VEGFA Proteins) has been reported.
Results show that both FLT1 and PGF (show PGF Proteins) are overexpressed in the circulating tumor cells (CTCs) of patients with breast cancer. Also, a functional interaction of sFlt1 and PGF (show PGF Proteins) was found, suggesting that their overexpression in tumor cells inhibits CTCs entering the peripheral blood.
Results indicate that chymotrypsin-like serine protease (show F2 Proteins) enhances soluble fms-like tyrosine kinase 1 production through protease-activated receptor-2 (show F2RL1 Proteins) in trophoblast cells and thus plays an important additional role in preeclampsia pathogenesis.
variants near FLT1 may modulate preeclampsia susceptibility
There is a possibility that steatosis can be suppressed by the CC genotype in VEGFR1.
These results suggest that non-dominant follicles maintain a greater concentration of the mRNA expression of both membrane and soluble VEGF receptors; but follicular dominance is related to a reduction in the mRNA expression of sVEGFR1 and sVEGFR2.
VEGFR-1 negatively regulates primary bovine retinal pericytes survival, and its blockade protects the blood-brain barrier integrity.
gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1
VEGFR1 mRNA expression was lower at estrus and at the early I and early II luteal stages than at the other stages, whereas VEGFR1 protein expression did not change significantly throughout the estrous cycle (P<0.05)
Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
inhibition of VEGFR-1 results in decrease in number of capillary connections indicating VEGFR-1 ligands promote branching angiogenesis.
TGF-beta1 (show TGFB1 Proteins) induction of VEGFR-1 in endothelial cells explains pericyte protection of vessels and the selective vulnerability of neonatal vessels to oxygen(VEGFR-1)
the activation of VEGFR-1 and VEGFR-2 (show KDR Proteins) heterodimer (VEGFR-1/R-2) is essential for PGI(2 (show PTGIR Proteins)) synthesis mediated by VEGF-A (show VEGFA Proteins)(165) and VEGF-A (show VEGFA Proteins)(121), which cannot be reproduced by the parallel activation of VEGFR-1 and VEGFR-2 (show KDR Proteins) homodimers with corresponding agonists
PEDF (show SERPINF1 Proteins) and VEGFR-1 have roles in the negative regulation of angiogenesis
we analyzed the expression and cellular distribution of Flt-1(VEGFR-1) and Flk-1 (KDR/VEGFR-2 (show KDR Proteins))in newborn piglet brain
data shows that members of the VEGF (show VEGFA Proteins)-VEGFR (show KDR Proteins) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy
The VEGFR1 was stably expressed during the whole lifespan of mesonephric glomeruli, and VEGFR1 is important for the maintenance of endothelial fenestrations.
increased placental expression of the VEGF receptor system is associated with increased placental vascular density observed with the advancement of gestation in the pig.
EGFR (show EGFR Proteins), VEGFR (show KDR Proteins) and FGFR (show FGFR2 Proteins) are expressed in porcine oviduct and endometrium during the time of implantation [review]
VEGF ligand-receptor system may play an important role in the development and maintenance of the corpus luteum in pigs.
VEGF (show VEGFA Proteins)/Flk-1 (show KDR Proteins)/Flt-1 system is activated during myocardial ischemia reperfusion injury.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (show VEGFA Proteins), pro-MMP-9 (show MMP9 Proteins), MMP-2 (show MMP2 Proteins), VEGFR-1, VEGFR-2 (show KDR Proteins), and TIMP-1 (show TIMP1 Proteins), which may contribute to the development of venous stenosis.
in experimental intervertebral disc degeneration, VEGF receptors were expressed in the damaged disc and paradiscal tissues
we determined that radial glia control this process via the Vegf (show VEGFA Proteins) decoy receptor sFlt1: sflt1 mutants exhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 overexpression rescues it. Genetic mosaic analyses show that sFlt1 function in trunk endothelial cells can limit their over-sprouting.
Flt1-tyrosine kinase (TK) activity contributed significantly in endothelial cells survival and vascular development during embryo angiogenesis in zebrafish by engaging PI3K/Akt (show AKT1 Proteins) pathway.
Elevated Notch (show NOTCH1 Proteins) signaling downstream of perturbed VEGF (show VEGFA Proteins) signaling contributes to aberrant flt-1(-/-) blood vessel formation.
Data indicate that the increase in FLT1/sFLT1 protein levels upon miR-10 (show LILRB2 Proteins) knockdown inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 (show KDR Proteins) signaling.
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
fms-related tyrosine kinase 1
, vascular endothelial growth factor receptor 1
, embryonic receptor kinase 2
, tyrosine-protein kinase receptor FLT
, vascular endothelial growth factor receptor-1
, vascular permeability factor receptor
, fms-like tyrosine kinase 1
, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
, tyrosine-protein kinase FRT
, FMS-like tyrosine kinase 1
, Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
, vascular endothelial growth factor 1
, vascular endothelial growth factor/vascular permeability factor receptor
, ascular endothelial growth factor/vascular permeability factor receptor
, flt-1 type VEGF receptor
, receptor tyrosine kinase Flt1b
, soluble fms-like tyrosine kinase 1