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Browse our FLT1 Proteins (FLT1)

Full name:
Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) Proteins (FLT1)
On www.antibodies-online.com are 68 Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) Proteins from 19 different suppliers available. Additionally we are shipping FLT1 Antibodies (291) and FLT1 Kits (61) and many more products for this protein. A total of 442 FLT1 products are currently listed.
Synonyms:
AI323757, FLT, FLT-1, FLT1, flt1b, sFlt1, VEGFR-1, VEGFR1
list all proteins Gene Name GeneID UniProt
FLT1 14254 P35969
FLT1 2321 P17948
FLT1 54251 P53767

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FLT1 Proteins (FLT1) by Origin

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Top referenced FLT1 Proteins

  1. Human FLT1 Protein expressed in HEK-293 - ABIN2666538 : Ambati, Nozaki, Singh, Takeda, Jani, Suthar, Albuquerque, Richter, Sakurai, Newcomb, Kleinman, Caldwell, Lin, Ogura, Orecchia, Samuelson, Agnew, St Leger, Green, Mahasreshti, Curiel, Kwan, Marsh et al.: Corneal avascularity is due to soluble VEGF receptor-1. ... in Nature 2006 (PubMed)
    Show all 7 references for ABIN2666538

  2. Human FLT1 Protein expressed in HEK-293 Cells - ABIN2181915 : Shibuya, Yamaguchi, Yamane, Ikeda, Tojo, Matsushime, Sato: Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. in Oncogene 1990 (PubMed)
    Show all 5 references for ABIN2181915

  3. Human FLT1 Protein expressed in Human Cells - ABIN2002150 : Kendall, Thomas: Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Show all 2 references for ABIN2002150

  4. Human FLT1 Protein expressed in Human Cells - ABIN2002149 : Starovasnik, Christinger, Wiesmann, Champe, de Vos, Skelton: Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states. in Journal of molecular biology 1999 (PubMed)
    Show all 2 references for ABIN2002149

More Proteins for FLT1 Interaction Partners

Mouse (Murine) Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) interaction partners

  1. data suggest that sFlt-1 may have a therapeutic effect on AS, resulting from suppression of VEGF signaling-mediated recruitment of circulating monocytes/macrophages

  2. that Flt-1 plays a critical role in cardiac hypertrophy induced by pressure overload via the activation of AKT (show AKT1 Proteins)

  3. Flt-1 appears to play a role in oxidative stress, which promotes apoptosis of trophoblasts

  4. This article reviews the current evidence on the clinical utility of the sFlt-1/PlGF (show PGF Proteins) ratio at different points in pregnancy and, accordingly, make a proposal for its clinical implementation. [review]

  5. cyclin A1 (show CCNA1 Proteins) in association with vascular endothelial growth factor receptor 1 (VEGFR1), is required for HSPC (show PSMA7 Proteins) and their niches to maintain their function and proper interaction

  6. VEGFR1 signaling facilitates angiogenesis in ischemia by recruiting CXCR4 (show CXCR4 Proteins)+VEGFR1-expressing cells from bone marrow.

  7. The hypoxia-induced rise in sFlt-1 levels seems not to be mediated by IL-6 (show IL6 Proteins) in vivo.

  8. FLT1 inhibition reduces tumor metastatic efficiency even after initial seeding, suggesting that these pathways represent therapeutic targets in metastatic disease.

  9. Vandetanib treatment can reduce arteriosclerosis induced by abdominal aorta transplantation by blocking VEGFR1 and VEGFR2 (show KDR Proteins) in endothelial progenitor cells

  10. Tumor-derived VEGF-A (show VEGFA Proteins), PLGF-2 (show PGF Proteins), and VEGF-B (show VEGFB Proteins) augment pain sensitivity through selective activation of VEGF receptor 1 (VEGFR1) expressed in sensory neurons in human cancer and mouse models.

Human Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) interaction partners

  1. Findings indicate that hnRNP (show HNRNPC Proteins) D and arginine methylation play important roles in the regulation of Flt-1 mRNA alternative polyadenylation.

  2. the target gene FLT1 regulated by miRNA-30e-3p and miRNA-369-3p may play key role in the progression and development of AD.

  3. High expression of VEGFR1 is associated with astrocytomas.

  4. Our results validate previous findings that suggest VEGFR1-positive cells in benign lymph nodes can predict clinical outcome

  5. soluble fms-like tyrosine kinase-1 and placental growth factor (show PGF Proteins) as biomarkers in patients with coronary artery disease

  6. VEGFR-1 activation-induced MMP-9 (show MMP9 Proteins)-dependent invasion in hepatocellular carcinoma

  7. Results show that overexpression of c-MET and its phosphorylation with up-regulation of VEGFR1 are associated with chemo-resistance phenotype of colon cancer.

  8. Higher sFlt-1 and lower VEGF levels in the group with preeclampsia, as well as higher sFlt-1 levels in small for gestational age neonates, reflect a predominance of antiangiogenic mechanisms in preeclampsia and growth restriction.

  9. There is a significant negative correlation between the concentration of sFLt-1 and PlGF (show PGF Proteins) in normal pregnancy.

  10. High expression levels of VEGFR1 and VEGFR3 (show FLT4 Proteins) were associated with a higher rate of lung metastasis.

Cow (Bovine) Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) interaction partners

  1. VEGFR-1 negatively regulates primary bovine retinal pericytes survival, and its blockade protects the blood-brain barrier integrity.

  2. gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1

  3. VEGFR1 mRNA expression was lower at estrus and at the early I and early II luteal stages than at the other stages, whereas VEGFR1 protein expression did not change significantly throughout the estrous cycle (P<0.05)

  4. Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

  5. inhibition of VEGFR-1 results in decrease in number of capillary connections indicating VEGFR-1 ligands promote branching angiogenesis.

  6. TGF-beta1 (show TGFB1 Proteins) induction of VEGFR-1 in endothelial cells explains pericyte protection of vessels and the selective vulnerability of neonatal vessels to oxygen(VEGFR-1)

  7. the activation of VEGFR-1 and VEGFR-2 (show KDR Proteins) heterodimer (VEGFR-1/R-2) is essential for PGI(2 (show PTGIR Proteins)) synthesis mediated by VEGF-A (show VEGFA Proteins)(165) and VEGF-A (show VEGFA Proteins)(121), which cannot be reproduced by the parallel activation of VEGFR-1 and VEGFR-2 (show KDR Proteins) homodimers with corresponding agonists

  8. PEDF (show SERPINF1 Proteins) and VEGFR-1 have roles in the negative regulation of angiogenesis

Pig (Porcine) Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) interaction partners

  1. we analyzed the expression and cellular distribution of Flt-1(VEGFR-1) and Flk-1 (KDR/VEGFR-2 (show KDR Proteins))in newborn piglet brain

  2. data shows that members of the VEGF (show VEGFA Proteins)-VEGFR (show KDR Proteins) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy

  3. The VEGFR1 was stably expressed during the whole lifespan of mesonephric glomeruli, and VEGFR1 is important for the maintenance of endothelial fenestrations.

  4. increased placental expression of the VEGF receptor system is associated with increased placental vascular density observed with the advancement of gestation in the pig.

  5. EGFR (show EGFR Proteins), VEGFR (show KDR Proteins) and FGFR (show FGFR2 Proteins) are expressed in porcine oviduct and endometrium during the time of implantation [review]

  6. VEGF ligand-receptor system may play an important role in the development and maintenance of the corpus luteum in pigs.

  7. VEGF (show VEGFA Proteins)/Flk-1 (show KDR Proteins)/Flt-1 system is activated during myocardial ischemia reperfusion injury.

  8. Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (show VEGFA Proteins), pro-MMP-9 (show MMP9 Proteins), MMP-2 (show MMP2 Proteins), VEGFR-1, VEGFR-2 (show KDR Proteins), and TIMP-1 (show TIMP1 Proteins), which may contribute to the development of venous stenosis.

  9. in experimental intervertebral disc degeneration, VEGF receptors were expressed in the damaged disc and paradiscal tissues

Zebrafish Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) interaction partners

  1. Flt1-tyrosine kinase (TK) activity contributed significantly in endothelial cells survival and vascular development during embryo angiogenesis in zebrafish by engaging PI3K/Akt (show AKT1 Proteins) pathway.

  2. Elevated Notch (show NOTCH1 Proteins) signaling downstream of perturbed VEGF (show VEGFA Proteins) signaling contributes to aberrant flt-1(-/-) blood vessel formation.

  3. Data indicate that the increase in FLT1/sFLT1 protein levels upon miR-10 (show LILRB2 Proteins) knockdown inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 (show KDR Proteins) signaling.

FLT1 Protein Profile

Protein Summary

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

Alternative names and synonyms associated with FLT1

  • fms-related tyrosine kinase 1 (FLT1)
  • vascular endothelial growth factor receptor 1 (CpipJ_CPIJ012087)
  • FMS-like tyrosine kinase 1 (Flt1)
  • FMS-related tyrosine kinase 1 (Flt1)
  • fms-related tyrosine kinase 1 (Flt1)
  • fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1)
  • fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (flt1)
  • vascular endothelial growth factor receptor-1 (FLT-1)
  • AI323757 protein
  • FLT protein
  • FLT-1 protein
  • FLT1 protein
  • flt1b protein
  • sFlt1 protein
  • VEGFR-1 protein
  • VEGFR1 protein

Protein level used designations for FLT1

fms-related tyrosine kinase 1 , vascular endothelial growth factor receptor 1 , embryonic receptor kinase 2 , tyrosine-protein kinase receptor FLT , vascular endothelial growth factor receptor-1 , vascular permeability factor receptor , fms-like tyrosine kinase 1 , fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) , tyrosine-protein kinase FRT , FLT-1 , FMS-like tyrosine kinase 1 , Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) , VEGF-receptor , flt-receptor , vascular endothelial growth factor 1 , vascular endothelial growth factor/vascular permeability factor receptor , ascular endothelial growth factor/vascular permeability factor receptor , VEGFR-1 , flt-1 type VEGF receptor , receptor tyrosine kinase Flt1b , soluble fms-like tyrosine kinase 1

GENE ID SPECIES
443088 Ovis aries
6044537 Culex quinquefasciatus
14254 Mus musculus
2321 Homo sapiens
54251 Rattus norvegicus
100732326 Cavia porcellus
503620 Bos taurus
403727 Canis lupus familiaris
374100 Gallus gallus
396763 Sus scrofa
544667 Danio rerio
443182 Ovis aries
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