You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our FLT1 Proteins (FLT1)

Full name:
Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) Proteins (FLT1)
On www.antibodies-online.com are 70 Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) Proteins from 21 different suppliers available. Additionally we are shipping FLT1 Antibodies (454) and FLT1 Kits (58) and many more products for this protein. A total of 602 FLT1 products are currently listed.
Synonyms:
AI323757, FLT, FLT-1, FLT1, flt1b, sFlt1, VEGFR-1, VEGFR1
list all proteins Gene Name GeneID UniProt
FLT1 14254 P35969
FLT1 2321 P17948
FLT1 54251 P53767

Show all synonyms

FLT1 Proteins (FLT1) by Origin

Select your origin of interest

Top referenced FLT1 Proteins

  1. Human FLT1 Protein expressed in HEK-293 - ABIN2666538 : Ambati, Nozaki, Singh, Takeda, Jani, Suthar, Albuquerque, Richter, Sakurai, Newcomb, Kleinman, Caldwell, Lin, Ogura, Orecchia, Samuelson, Agnew, St Leger, Green, Mahasreshti, Curiel, Kwan, Marsh et al.: Corneal avascularity is due to soluble VEGF receptor-1. ... in Nature 2006 (PubMed)
    Show all 7 references for ABIN2666538

  2. Human FLT1 Protein expressed in HEK-293 Cells - ABIN2181915 : Shibuya, Yamaguchi, Yamane, Ikeda, Tojo, Matsushime, Sato: Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. in Oncogene 1990 (PubMed)
    Show all 5 references for ABIN2181915

  3. Human FLT1 Protein expressed in Human Cells - ABIN2002150 : Kendall, Thomas: Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Show all 2 references for ABIN2002150

  4. Human FLT1 Protein expressed in Human Cells - ABIN2002149 : Starovasnik, Christinger, Wiesmann, Champe, de Vos, Skelton: Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states. in Journal of molecular biology 1999 (PubMed)
    Show all 2 references for ABIN2002149

More Proteins for FLT1 Interaction Partners

Mouse (Murine) Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) interaction partners

  1. these results suggest that VEGFR1 signaling plays a role in regulating the balance between macrophage phenotypes in streptozotocin -induced diabetic wounds, prevents impaired diabetic wound healing, and promotes angiogenesis/lymphangiogenesis.

  2. These data therefore support a tightly controlled, paracrine signaling mechanism of VEGF-B (show VEGFB Proteins) to VEGFR1.

  3. Flt1/VEGF-A (show VEGFA Proteins) signalling has stage-specific effects on vascular morphogenesis.

  4. IL-35 treatment reduced collagen-induced arthritis via inhibiting vascular endothelial growth factor and its receptors

  5. the VEGFR-1 tyrosine kinase (show TYRO3 Proteins) signaling has an effect on angiogenesis.

  6. data suggest that sFlt-1 may have a therapeutic effect on AS, resulting from suppression of VEGF signaling-mediated recruitment of circulating monocytes/macrophages

  7. that Flt-1 plays a critical role in cardiac hypertrophy induced by pressure overload via the activation of AKT (show AKT1 Proteins)

  8. Flt-1 appears to play a role in oxidative stress, which promotes apoptosis of trophoblasts

  9. This article reviews the current evidence on the clinical utility of the sFlt-1/PlGF (show PGF Proteins) ratio at different points in pregnancy and, accordingly, make a proposal for its clinical implementation. [review]

  10. cyclin A1 (show CCNA1 Proteins) in association with vascular endothelial growth factor receptor 1 (VEGFR1), is required for HSPC (show PSMA7 Proteins) and their niches to maintain their function and proper interaction

Human Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) interaction partners

  1. our data demonstrate an association of higher levels of sFLT-1 with increased expression of miR (show MLXIP Proteins)-195-5p in preeclampsia pregnant women.

  2. membranebound VEGFR1 is frequently expressed in normal and cancerous breast epithelium. In addition, reduced or lost VEGFR1 expression may serve as a marker for poor prognosis in patients with breast cancer, who might not optimally benefit from endocrine therapy.

  3. These studies identify uPA (show PRAP1 Proteins)-dependent de-repression of vegfr1 and vegfr2 (show KDR Proteins) gene transcription through binding to HHEX/PRH (show HHEX Proteins) as a novel mechanism by which uPA (show PRAP1 Proteins) mediates the pro-angiogenic effects of VEGF (show VEGFA Proteins) and identifies a potential new target for control of pathologic angiogenesis.

  4. This study aimed to analyze the ultrastructure and histomorphometric changes of the human umbilical cord vessels of preeclampsia compared to healthy pregnancies and the possible role of vascular endothelial growth factor (VEGF) and its receptors.

  5. Our results indicate that the genetically coded increased expression of FLT1 by a functional SNP implicates activation in an inflammatory cascade that might eventually lead to CAD.

  6. sFlt-1 concentrations in saliva (show RAG1AP1 Proteins) and gingival crevicular fluid were significantly higher in patients with pre-eclampsia.

  7. Flt-1 blood levels are increased in women who developed early- or late-onset preeclampsia.

  8. CAIX (show CA9 Proteins) and PTEN had prognostic importance for metastatic renal cell carcinoma (show MOK Proteins) patients receiving first-line VEGFR (show KDR Proteins) TKI. Future validation and mechanistic studies are required.

  9. Underexpression of FLT1 is associated with HPV-positive head and neck cancers.

  10. Studies indicate that natural products have shown efficacy and noted to be exert tumor suppressive effects via inhibition of VEGF (show VEGFA Proteins) and VEGFR (show KDR Proteins) both at mRNA and protein level.

Cow (Bovine) Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) interaction partners

  1. These results suggest that non-dominant follicles maintain a greater concentration of the mRNA expression of both membrane and soluble VEGF receptors; but follicular dominance is related to a reduction in the mRNA expression of sVEGFR1 and sVEGFR2.

  2. VEGFR-1 negatively regulates primary bovine retinal pericytes survival, and its blockade protects the blood-brain barrier integrity.

  3. gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1

  4. VEGFR1 mRNA expression was lower at estrus and at the early I and early II luteal stages than at the other stages, whereas VEGFR1 protein expression did not change significantly throughout the estrous cycle (P<0.05)

  5. Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

  6. inhibition of VEGFR-1 results in decrease in number of capillary connections indicating VEGFR-1 ligands promote branching angiogenesis.

  7. TGF-beta1 (show TGFB1 Proteins) induction of VEGFR-1 in endothelial cells explains pericyte protection of vessels and the selective vulnerability of neonatal vessels to oxygen(VEGFR-1)

  8. the activation of VEGFR-1 and VEGFR-2 (show KDR Proteins) heterodimer (VEGFR-1/R-2) is essential for PGI(2 (show PTGIR Proteins)) synthesis mediated by VEGF-A (show VEGFA Proteins)(165) and VEGF-A (show VEGFA Proteins)(121), which cannot be reproduced by the parallel activation of VEGFR-1 and VEGFR-2 (show KDR Proteins) homodimers with corresponding agonists

  9. PEDF (show SERPINF1 Proteins) and VEGFR-1 have roles in the negative regulation of angiogenesis

Pig (Porcine) Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) interaction partners

  1. we analyzed the expression and cellular distribution of Flt-1(VEGFR-1) and Flk-1 (KDR/VEGFR-2 (show KDR Proteins))in newborn piglet brain

  2. data shows that members of the VEGF (show VEGFA Proteins)-VEGFR (show KDR Proteins) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy

  3. The VEGFR1 was stably expressed during the whole lifespan of mesonephric glomeruli, and VEGFR1 is important for the maintenance of endothelial fenestrations.

  4. increased placental expression of the VEGF receptor system is associated with increased placental vascular density observed with the advancement of gestation in the pig.

  5. EGFR (show EGFR Proteins), VEGFR (show KDR Proteins) and FGFR (show FGFR2 Proteins) are expressed in porcine oviduct and endometrium during the time of implantation [review]

  6. VEGF ligand-receptor system may play an important role in the development and maintenance of the corpus luteum in pigs.

  7. VEGF (show VEGFA Proteins)/Flk-1 (show KDR Proteins)/Flt-1 system is activated during myocardial ischemia reperfusion injury.

  8. Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (show VEGFA Proteins), pro-MMP-9 (show MMP9 Proteins), MMP-2 (show MMP2 Proteins), VEGFR-1, VEGFR-2 (show KDR Proteins), and TIMP-1 (show TIMP1 Proteins), which may contribute to the development of venous stenosis.

  9. in experimental intervertebral disc degeneration, VEGF receptors were expressed in the damaged disc and paradiscal tissues

Zebrafish Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) interaction partners

  1. Flt1-tyrosine kinase (TK) activity contributed significantly in endothelial cells survival and vascular development during embryo angiogenesis in zebrafish by engaging PI3K/Akt (show AKT1 Proteins) pathway.

  2. Elevated Notch (show NOTCH1 Proteins) signaling downstream of perturbed VEGF (show VEGFA Proteins) signaling contributes to aberrant flt-1(-/-) blood vessel formation.

  3. Data indicate that the increase in FLT1/sFLT1 protein levels upon miR-10 (show LILRB2 Proteins) knockdown inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 (show KDR Proteins) signaling.

FLT1 Protein Profile

Protein Summary

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

Alternative names and synonyms associated with FLT1

  • fms-related tyrosine kinase 1 (FLT1)
  • vascular endothelial growth factor receptor 1 (CpipJ_CPIJ012087)
  • FMS-like tyrosine kinase 1 (Flt1)
  • FMS-related tyrosine kinase 1 (Flt1)
  • fms-related tyrosine kinase 1 (Flt1)
  • fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1)
  • fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (flt1)
  • vascular endothelial growth factor receptor-1 (FLT-1)
  • AI323757 protein
  • FLT protein
  • FLT-1 protein
  • FLT1 protein
  • flt1b protein
  • sFlt1 protein
  • VEGFR-1 protein
  • VEGFR1 protein

Protein level used designations for FLT1

fms-related tyrosine kinase 1 , vascular endothelial growth factor receptor 1 , embryonic receptor kinase 2 , tyrosine-protein kinase receptor FLT , vascular endothelial growth factor receptor-1 , vascular permeability factor receptor , fms-like tyrosine kinase 1 , fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) , tyrosine-protein kinase FRT , FLT-1 , FMS-like tyrosine kinase 1 , Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) , VEGF-receptor , flt-receptor , vascular endothelial growth factor 1 , vascular endothelial growth factor/vascular permeability factor receptor , ascular endothelial growth factor/vascular permeability factor receptor , VEGFR-1 , flt-1 type VEGF receptor , receptor tyrosine kinase Flt1b , soluble fms-like tyrosine kinase 1

GENE ID SPECIES
443088 Ovis aries
6044537 Culex quinquefasciatus
14254 Mus musculus
2321 Homo sapiens
54251 Rattus norvegicus
100732326 Cavia porcellus
503620 Bos taurus
403727 Canis lupus familiaris
374100 Gallus gallus
396763 Sus scrofa
544667 Danio rerio
443182 Ovis aries
Selected quality suppliers for FLT1 Proteins (FLT1)
Did you look for something else?