We are preparing the requested document. Please wait, this may take a while...!
|Antigen||Fms-Related tyrosine Kinase 3 (FLT3) Antibodies|
|Conjugate||This FLT3 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-FLT3 AntibodyTarget Details FLT3 Application Details Handling References for anti-FLT3 antibody (ABIN359869) Images
|Specificity||This antibody reacts to FLT3 (CD135).|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human FLT3.|
Target Details FLT3Product Details anti-FLT3 Antibody Application Details Handling References for anti-FLT3 antibody (ABIN359869) Images back to top
|Alternative Name||CD135 / FLT3 (FLT3 Antibody Abstract)|
|Background||Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).Synonyms: FL cytokine receptor, STK1, Stem cell tyrosine kinase 1, Tyrosine-protein kinase receptor FLT3|
|Gene ID||2322, 9606|
|Research Area||CD Antigens, Surface Receptors of Immune Cells|
Application DetailsProduct Details anti-FLT3 Antibody Target Details FLT3 Handling References for anti-FLT3 antibody (ABIN359869) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50- 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-FLT3 Antibody Target Details FLT3 Application Details References for anti-FLT3 antibody (ABIN359869) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-FLT3 antibody (ABIN359869)Product Details anti-FLT3 Antibody Target Details FLT3 Application Details Handling Images back to top
Seidlits, Reza, Briand, Sereno: "Voluntary spatial attention has different effects on voluntary and reflexive saccades." in: TheScientificWorldJournal, Vol. 3, pp. 881-902, 2003
Minami, Yamamoto, Kiyoi, Ueda, Saito, Naoe: "Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia." in: Blood, Vol. 102, Issue 8, pp. 2969-75, 2003
Zwaan, Meshinchi, Radich, Veerman, Huismans, Munske, Podleschny, Hählen, Pieters, Zimmermann, Reinhardt, Harbott, Creutzig, Kaspers, Griesinger: "FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: prognostic significance and relation to cellular drug resistance." in: Blood, Vol. 102, Issue 7, pp. 2387-94, 2003
Galimberti, Rossi, Palumbo, Morabito, Guerrini, Vincelli, Fazzi, Santini, Petrini: "FLT3 mutations do not influence MDR-1 gene expression in acute myeloid leukemia." in: Anticancer research, Vol. 23, Issue 4, pp. 3419-26, 2003
Kottaridis, Gale, Linch: "Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia." in: Leukemia & lymphoma, Vol. 44, Issue 6, pp. 905-13, 2003
ImagesProduct Details anti-FLT3 Antibody Target Details FLT3 Application Details Handling References for anti-FLT3 antibody (ABIN359869) back to top