We are preparing the requested document. Please wait, this may take a while...!
|Antigen||Fms-Related tyrosine Kinase 3 (FLT3) Antibodies|
|Epitope||pTyr589, pTyr591 Alternatives|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This FLT3 antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-FLT3 AntibodyTarget Details FLT3 Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic phosphopeptide derived from human FLT3 around the phosphorylation site of Tyr589/591|
Target Details FLT3Product Details anti-FLT3 Antibody Application Details Handling Images back to top
|Alternative Name||Flt3 (FLT3 Antibody Abstract)|
CD135 is a tyrosine kinase receptor expressed on normal cells including CD34+ hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. CD135 is also expressed on malignant hematopoietic cells including AML, ALL and CML BC. CD135, also known as FMS-like tyrosine kinase 3, FLT3, STK1, and Flk2, is a growth factor receptor that binds the FLT3 ligand to promote the growth and differentiation of primitive hematopoietic cells. The intracytoplasmic domain of CD135 is modified by phosphorylation and has been shown to interact with Grb2, SOCS1, VAV1, and Shc. In humans, expression of Flt3 is restricted to subsets of CD34 positive as well as CD34 negative normal bone marrow cells. In these cells, the level of expression of Flt3 is rather low. Most of the CD34 bright Flt3+ cells co-express CD117 at high levels. They may represent early cycling, but not quiescent stem cells. Flt3+ cells in the CD34lo and CD34- populations do not co-express CD117 Molecule and may represent B lymphoid precursors.
Synonyms: CD135 antigen, Fetal liver kinase 2, FL cytokine receptor, Flk 2, Flk2, Flt 3, Flt3, FMS like tyrosine kinase 3, Fms related tyrosine kinase 3, Growth factor receptor tyrosine kinase type III, Stem cell tyrosine kinase 1, Stk 1, Stk1, Tyrosine protein kinase receptor FLT3, FLT3_HUMAN.
Application DetailsProduct Details anti-FLT3 Antibody Target Details FLT3 Handling Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-FLT3 Antibody Target Details FLT3 Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
ImagesProduct Details anti-FLT3 Antibody Target Details FLT3 Application Details Handling back to top