Recognizes human VEGF Receptor 3 (FLT4). Western blot and ELISA demonstrate that the antibody is highly specific for VEGFR-3 with no cross-reactivity with human VEGFR-1 or VEGFR-2 protein. VEGFR-3 is not expressed in HEVs of the lymph nodes. In lymphomas staining is seen mostly in collapsed vessels in the cortex of lymph nodes infiltrated by the lymphoma cells. The antibody specifically detects lymphatic endothelium in human lymph node and other organs such as tonsil.
Purified recombinant human VEGFR-3 extracellular domain protein expressed in baculovirus culture.