anti-Rat (Rattus) FLT4 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended FLT4 Antibody (supplied by: Log in to see )

Antigen
Fms-Related Tyrosine Kinase 4 (FLT4) Antibodies
  • AI323512
  • Chy
  • Flt-4
  • VEGFR-3
  • VEGFR3
  • FLT41
  • LMPH1A
  • PCL
  • Vegfr3
  • cb1059
  • 6130401C07
  • Flk-1
  • Flk1
  • Krd-1
  • Ly73
  • VEGFR-2
  • VEGFR2
  • sVEGFR-2
  • FMS-like tyrosine kinase 4
  • fms-related tyrosine kinase 4
  • kinase insert domain protein receptor
  • Flt4
  • FLT4
  • flt4
  • Kdr
Epitope
AA 910-960
30
21
15
15
14
12
10
10
9
7
6
6
4
3
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
198
129
45
Host
Rabbit
124
94
48
9
1
Clonality
Polyclonal
Conjugate
This FLT4 antibody is un-conjugated
19
10
8
6
6
6
5
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
174
106
91
66
65
27
25
24
11
9
6
5
3
3
3
3
2
2
2
1
1
Options
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Catalog No. ABIN678578
$ 307.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN5518991 IHC (p) WB Rabbit IgG Log in to see Polyclonal
1 ABIN737406 IF (p) IHC (p) WB Rabbit IgG AA 920-970 Log in to see Polyclonal 1
1 ABIN1492009 IHC (p) IP WB Rabbit C-Term Log in to see Polyclonal
1 ABIN737415 IHC (p) WB HRP Rabbit IgG AA 920-970 Log in to see Polyclonal
1 ABIN678587 IHC (p) WB HRP Rabbit IgG AA 910-960 Log in to see Polyclonal
1 ABIN737408 IHC (p) WB Biotin Rabbit IgG AA 920-970 Log in to see Polyclonal
1 ABIN678580 IHC (p) WB Biotin Rabbit IgG AA 910-960 Log in to see Polyclonal
1 ABIN4901547 ELISA IHC (p) WB Rabbit IgG Log in to see Polyclonal
1 ABIN4365190 IHC IHC (p) Rabbit C-Term Log in to see Polyclonal
1 ABIN1804664 IHC (p) ELISA Rabbit Log in to see Polyclonal
1 ABIN1734382 IHC (p) IP WB Rabbit IgG C-Term Log in to see Polyclonal
1 ABIN5552442 IHC (p) WB Rabbit C-Term Log in to see Polyclonal
1 ABIN1839820 IHC (p) Rabbit C-Term Log in to see Polyclonal
1 ABIN329911 IHC (p) Rabbit IgG C-Term Log in to see Polyclonal

General

Antigen Fms-Related Tyrosine Kinase 4 (FLT4) Antibodies
Epitope AA 910-960
(30), (21), (15), (15), (14), (12), (10), (10), (9), (7), (6), (6), (4), (3), (2), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(198), (129), (45)
Host Rabbit
(124), (94), (48), (9), (1)
Clonality
Polyclonal
Conjugate This FLT4 antibody is un-conjugated
(19), (10), (8), (6), (6), (6), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(174), (106), (91), (66), (65), (27), (25), (24), (11), (9), (6), (5), (3), (3), (3), (3), (2), (2), (2), (1), (1)
Pubmed 3 references available
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Product Details anti-FLT4 Antibody

Target Details FLT4 Application Details Handling References for anti-FLT4 antibody (ABIN678578) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human VEGFR-3
Isotype IgG

Target Details FLT4

Product Details anti-FLT4 Antibody Application Details Handling References for anti-FLT4 antibody (ABIN678578) Images back to top
Antigen
Alternative Name Vegfr3 (FLT4 Antibody Abstract)
Background

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades, isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.

Subcellular location: Cytoplasm

Synonyms: PCL, FLT41, LMPH1A, VEGFR3, Vascular endothelial growth factor receptor 3, VEGFR-3, Fms-like tyrosine kinase 4, FLT-4, Tyrosine-protein kinase receptor FLT4, FLT4

Gene ID 2324
UniProt P35916
Pathways RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling

Application Details

Product Details anti-FLT4 Antibody Target Details FLT4 Handling References for anti-FLT4 antibody (ABIN678578) Images back to top
Application Notes WB 1:100-1000
FCM 1:20-100
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-FLT4 Antibody Target Details FLT4 Application Details References for anti-FLT4 antibody (ABIN678578) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-FLT4 antibody (ABIN678578)

Product Details anti-FLT4 Antibody Target Details FLT4 Application Details Handling Images back to top
Product cited in:

Wang, Wang, Li, Wu, Sun, Chen, Feng, Chen, Cai, Xu, He: "CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrin β1/FAK/AKT signaling." in: Cancer letters, Vol. 385, pp. 28-38, 2016 Method employed by authors: Immunofluorescence (fixed cells) (IF/ICC) (Sample species: Human).

Zhuo, Jia, Song, Lu, Ding, Wang, Song, Fu, Luo: "The CXCL12-CXCR4 chemokine pathway: a novel axis regulates lymphangiogenesis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 19, pp. 5387-98, 2012

Wang, Zhou, Lin, Wang, Lin, Li: "RhGH attenuates ischemia injury of intrahepatic bile ducts relating to liver transplantation." in: The Journal of surgical research, Vol. 171, Issue 1, pp. 300-10, 2011

Images

Product Details anti-FLT4 Antibody Target Details FLT4 Application Details Handling References for anti-FLT4 antibody (ABIN678578) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Fms-Related Tyrosine Kinase 4 (FLT4) (AA 910-960) antibody (ABIN678578) Formalin-fixed and paraffin embedded human gastric cancer labeled with Anti-VEGFR3 Po...
Immunohistochemistry (IHC) image for anti-Fms-Related Tyrosine Kinase 4 (FLT4) (AA 910-960) antibody (ABIN678578) Formalin-fixed and paraffin embedded human gastric cancer labeled with Anti-VEGFR3 P...
Flow Cytometry (FACS) image for anti-Fms-Related Tyrosine Kinase 4 (FLT4) (AA 910-960) antibody (ABIN678578) A549 cells probed with VEGFR3 Polyclonal Antibody, Unconjugated at 1:100 for 30 min...