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Gas6 stimulates angiogenesis of human retinal endothelial cells and of zebrafish embryos via ERK1/2 signaling.
Gas6 and Axl (show AXL Proteins) serum levels increase in parallel to chronic liver disease progression inactivation.
Gas6, through upregulation of Ptges (show PTGES Proteins)/PGE2, contributes to cancer-induced venous thrombosis.
Gas6-induced Axl (show AXL Proteins) signaling is a critical driver of pancreatic cancer progression.
Gas6/Axl (show AXL Proteins) signaling is essential for delaying the cellular senescence process regulated by the PI3K/Akt (show AKT1 Proteins)/FoxO (show FOXO3 Proteins) signaling pathway.
The up-regulation of Gas6/Axl (show AXL Proteins) signaling is a protective mechanism which reduces tubulo-interstitial apoptosis and slows progression to end-stage renal failure.
Optimal TAM (show CCNA1 Proteins) signaling requires coincident TAM (show CCNA1 Proteins) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (show CCNA1 Proteins) receptor tyrosine kinases Tyro3 (show TYRO3 Proteins), Axl (show AXL Proteins), and Mer (show ERH Proteins) and their ligands Gas6 and Protein S.
Inhibition of the Gas6 receptor Mer (show ERH Proteins) or therapeutic targeting of Gas6 by warfarin reduced myeloma burden and improved survival in a systemic model of myeloma.
data are consistent with Growth arrest-specific protein 6 being neuroprotective during experimental autoimmune encephalomyelitis by dampening the inflammatory response, thereby preserving axonal integrity and myelination.
These results demonstrate that Gas6 enhances several features of fungal allergic airway disease.
The expression of TAM (show CCNA1 Proteins) receptor tyrosine kinases and their ligand Gas6 is markedly downregulated in psoriatic epidermis. These data are in concordance with earlier study, demonstrating that TAM (show CCNA1 Proteins)-deficient mice develop systemic autoimmunity.
GAS6 intron 8 c.834 + 7G > A polymorphism was not associated with diabetic nephropathy in type 2 diabetes mellitus. However, heterozygous state of this polymorphism may be a risk factor for diabetic retinopathy in patients with diabetic nephropathy.
decreased plasma Gas6 concentration and labial (show LAT2 Proteins) salivary gland expression were associated with primary Sjogren syndrome(pSS (show CDSN Proteins)); Gas6 may represent a novel independent risk factor for pSS (show CDSN Proteins), with a potential role in salivary gland inflammation and dysfunction
Gas6 increases the metastatic capacity of oral squamous cell carcinoma(OSCC) cells and serum Gas6 could be a candidate biomarker for diagnostic and prognostic use in OSCC patients.
Gas6 gene variants are associated with IR, although their effects on subsequent progression to T2D were minimal in this prospective Asian cohort
Data shoed increased GAS6 and decreased MGP (show MGP Proteins) levels in hemodialysis patients, as mediators of induction or prevention of vascular calcification.
genetic variability of GAS6 and PEAR1 (show PEAR1 Proteins) genes may be associated with platelet hyperaggregability
Suggest an association between low plasma GAS6 levels and conventional cardiometabolic risk factors in psoriasis.
a protective role for AA Gas6 variant in type 2 diabetic patients may be concluded
This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
growth arrest specific 6
, growth arrest-specific protein 6
, growth arrest-specific 6
, growth arrest-specific protein 6-like
, AXL receptor tyrosine kinase ligand
, GAS 6
, growth-potentiating factor
, AXL stimulatory factor