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Gas6 stimulates angiogenesis of human retinal endothelial cells and of zebrafish embryos via ERK1/2 signaling.
Taken together, in our study Gas6 fails to aggravate calcification against the previous assumption.
The present study provides evidence that the vitamin K-dependent protein growth arrest specific 6 (Gas6) promotes such repair in in vitro cultures of mouse optic nerve and cerebellum.
Gas6 specifically promotes the recruitment of inflammatory CCR2 (show CCR2 Proteins)(hi)CX3CR1 (show CX3CR1 Proteins)(lo) monocytes through the regulation of both CCR2 (show CCR2 Proteins) and CCL2 (show CCL2 Proteins) during deep venous thrombosis.
Gas6/Axl (show AXL Proteins) and Akt (show AKT1 Proteins)/FoxO1a (show FOXO1 Proteins) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Gas6-mediated uptake is not a means to clear the bulk of circulating membrane-derived microparticles (PMPs) but may serve to locally phagocytose PMPs generated at sites of platelet activation and as a way to effect endothelial responses.
Gas6-FoxO-1 (show FOXO1 Proteins) signaling axis plays an important role in VCAM-1 (show VCAM1 Proteins) expression in the context of venous thromboembolism by promoting bone marrow mononuclear cell-endothelial cell adhesion.
Gas6 and Axl (show AXL Proteins) serum levels increase in parallel to chronic liver disease progression inactivation.
Gas6, through upregulation of Ptges (show PTGES Proteins)/PGE2, contributes to cancer-induced venous thrombosis.
Gas6-induced Axl (show AXL Proteins) signaling is a critical driver of pancreatic cancer progression.
Gas6/Axl (show AXL Proteins) signaling is essential for delaying the cellular senescence process regulated by the PI3K/Akt (show AKT1 Proteins)/FoxO (show FOXO3 Proteins) signaling pathway.
The GAS6-AXL (show AXL Proteins) signaling network is a mesenchymal (Mes (show ME1 Proteins)) molecular subtype-specific therapeutic target for ovarian cancer
The expression of AXL was positively associated with GAS6 expression (P < 0.001), and tumor differentiation (P = 0.014) in advanced NSCLC with metastases. AXL expression displayed no association with gender, age, smoking history, pathology, T stage, N stage, CEA, and LDH.
These results demonstrate that Gas6/Axl (show AXL Proteins) axis confers aggressiveness in breast cancer.
Inhibition of the GAS6/AXL (show AXL Proteins) pathway augments the efficacy of chemotherapies
In conclusion, our study shows that SNPsrs8191974 and rs2028299 of the Gas6 are significantly associated with type 2 diabetes mellitus (T2DM) in the Chinese population
High GAS6 expression is associated with Multiple Myeloma.
Data show that the variant growth arrest specific 6 (GAS6) +1332 T allele is associated with a decreased risk for severe preeclampsia in a South West Han Chinese population, but the 834+7G/A polymorphism has no effect on the severe preeclampsia.
Gas6 plasma level within 24 hours of ICU admission may predicts in-ICU mortality in patients with sepsis
Taken together, these results indicate that E2 exerts inhibitory effects on VSMC apoptosis and calcification through ERalpha (show ESR1 Proteins)-mediated Gas6 transactivation. These findings indicate a potential therapeutic strategy for the prevention of vascular calcification, especially in postmenopausal women.
In this paper, we review the biology of the Gas6/Tyro3 (show TYRO3 Proteins), Axl (show AXL Proteins), and MerTK (show MERTK Proteins)(collectively named TAM (show CCNA1 Proteins) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .
The results imply that the GAS6 gene can be considered a potential candidate for meat quality trait selection and fat deposition in pigs.
This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
growth arrest specific 6
, growth arrest-specific protein 6
, growth arrest-specific 6
, growth arrest-specific protein 6-like
, AXL receptor tyrosine kinase ligand
, GAS 6
, growth-potentiating factor
, AXL stimulatory factor