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Gas6 stimulates angiogenesis of human retinal endothelial cells and of zebrafish embryos via ERK1/2 signaling.
Gas6/Axl (show AXL Proteins) and Akt (show AKT1 Proteins)/FoxO1a (show FOXO1 Proteins) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Gas6-mediated uptake is not a means to clear the bulk of circulating membrane-derived microparticles (PMPs) but may serve to locally phagocytose PMPs generated at sites of platelet activation and as a way to effect endothelial responses.
Gas6-FoxO-1 (show FOXO1 Proteins) signaling axis plays an important role in VCAM-1 (show VCAM1 Proteins) expression in the context of venous thromboembolism by promoting bone marrow mononuclear cell-endothelial cell adhesion.
Gas6 and Axl (show AXL Proteins) serum levels increase in parallel to chronic liver disease progression inactivation.
Gas6, through upregulation of Ptges (show PTGES Proteins)/PGE2, contributes to cancer-induced venous thrombosis.
Gas6-induced Axl (show AXL Proteins) signaling is a critical driver of pancreatic cancer progression.
Gas6/Axl (show AXL Proteins) signaling is essential for delaying the cellular senescence process regulated by the PI3K/Akt (show AKT1 Proteins)/FoxO (show FOXO3 Proteins) signaling pathway.
The up-regulation of Gas6/Axl (show AXL Proteins) signaling is a protective mechanism which reduces tubulo-interstitial apoptosis and slows progression to end-stage renal failure.
Optimal TAM (show CCNA1 Proteins) signaling requires coincident TAM (show CCNA1 Proteins) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (show CCNA1 Proteins) receptor tyrosine kinases Tyro3 (show TYRO3 Proteins), Axl (show AXL Proteins), and Mer (show ERH Proteins) and their ligands Gas6 and Protein S.
Inhibition of the Gas6 receptor Mer (show ERH Proteins) or therapeutic targeting of Gas6 by warfarin reduced myeloma burden and improved survival in a systemic model of myeloma.
Taken together, these results indicate that E2 exerts inhibitory effects on VSMC apoptosis and calcification through ERalpha (show ESR1 Proteins)-mediated Gas6 transactivation. These findings indicate a potential therapeutic strategy for the prevention of vascular calcification, especially in postmenopausal women.
In this paper, we review the biology of the Gas6/Tyro3 (show TYRO3 Proteins), Axl (show AXL Proteins), and MerTK (show MERTK Proteins)(collectively named TAM (show CCNA1 Proteins) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .
serum testosterone and GAS6 levels were positively associated in male patients with coronary heart disease
investigation of the prognostic values of stromal NK cells and Gas6 in triple negative breast cancer (TNBC), and to eventually establish a prognostic risk model for patients with TNBC
CONCLUSIONS: Our results suggest that GAS6 c.834 + 7G> A polymorphism may have a pivotal role in the pathogenesis of preeclampsia (PE) suggesting that the A allele has a protective role for PE.
High expression of Gas6 correlated with Upper Tract Urothelial Carcinoma.
GAS6 intron 8 c.834 + 7G > A polymorphism was not associated with diabetic nephropathy in type 2 diabetes mellitus. However, heterozygous state of this polymorphism may be a risk factor for diabetic retinopathy in patients with diabetic nephropathy.
decreased plasma Gas6 concentration and labial (show LAT2 Proteins) salivary gland expression were associated with primary Sjogren syndrome(pSS (show CDSN Proteins)); Gas6 may represent a novel independent risk factor for pSS (show CDSN Proteins), with a potential role in salivary gland inflammation and dysfunction
The results imply that the GAS6 gene can be considered a potential candidate for meat quality trait selection and fat deposition in pigs.
This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
growth arrest specific 6
, growth arrest-specific protein 6
, growth arrest-specific 6
, growth arrest-specific protein 6-like
, AXL receptor tyrosine kinase ligand
, GAS 6
, growth-potentiating factor
, AXL stimulatory factor