Browse our GFR Proteins (RAPGEF5)

Full name:
Rap Guanine Nucleotide Exchange Factor (GEF) 5 Proteins (RAPGEF5)
On are 5 Rap Guanine Nucleotide Exchange Factor (GEF) 5 (RAPGEF5) Proteins from 3 different suppliers available. Additionally we are shipping GFR Antibodies (66) and GFR Kits (1) and many more products for this protein. A total of 77 GFR products are currently listed.
4932413M22, C86120, D030051B22Rik, GFR, MGC154311, mKIAA0277, mmr-gef, MR-GEF, Mrgef, REPAC, RGD1562891, rMR-GEF
list all proteins Gene Name GeneID UniProt
RAPGEF5 9771 Q92565
RAPGEF5 217944 Q8C0Q9
RAPGEF5 362799 P83900

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Human Rap Guanine Nucleotide Exchange Factor (GEF) 5 (RAPGEF5) interaction partners

  1. Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome

  2. We identified two novel genes, SOS2 (show SOS2 Proteins) and LZTR1 (show LZTR1 Proteins), associated with Noonan syndrome, thereby expanding the molecular spectrum of RASopathies.

  3. multicenter pharmacogenetic study in children (ages 6-11): Data suggest that SNP in SOS2 (show SOS2 Proteins) (rs13379306) in children with growth hormone (show GH1 Proteins) deficiency is associated with drug resistance to hormone replacement therapy with recombinant human growth hormone (show GH1 Proteins).

  4. intracellular Francisella tularensis novicida triggers temporal and early activation of Ras through the SOS2/GrB2/PKCalpha/PKCbetaI quaternary complex; Ras signalling by intracellular F. tularensis is essential for intracellular proliferation in the cytosol

  5. Significant association of single nucleotide polymorphism within three genes--PPARgamma (show PPARG Proteins), SOS2 (show SOS2 Proteins), and PCK1 (show PCK1 Proteins)--with Alzheimer's disease, was confirmed.

  6. Loss of MADD (show ETFA Proteins) expression resulted in reduced Grb2 (show GRB2 Proteins) and Sos1 (show SOS1 Proteins)/2 recruitment to the TNFR1 (show TNFRSF1A Proteins) complex and decreased Ras and MEKK1 (show MAP3K1 Proteins)/2 activation

GFR (RAPGEF5) Protein Profile

Protein Summary

Members of the RAS (see HRAS\; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000

Alternative names and synonyms associated with GFR (RAPGEF5)

  • Rap guanine nucleotide exchange factor (GEF) 5 (RAPGEF5)
  • Rap guanine nucleotide exchange factor (GEF) 5 (rapgef5)
  • Rap guanine nucleotide exchange factor (GEF) 5 (Rapgef5)
  • son of sevenless homolog 2 (Drosophila) (SOS2)
  • 4932413M22 protein
  • C86120 protein
  • D030051B22Rik protein
  • GFR protein
  • MGC154311 protein
  • mKIAA0277 protein
  • mmr-gef protein
  • MR-GEF protein
  • Mrgef protein
  • REPAC protein
  • RGD1562891 protein
  • rMR-GEF protein

Protein level used designations for RAPGEF5

Rap guanine nucleotide exchange factor (GEF) 5 , rap guanine nucleotide exchange factor 5 , rap guanine nucleotide exchange factor 5-like , M-Ras-regulated GEF , M-Ras-regulated Rap GEF , guanine nucleotide exchange factor for Rap1 , related to Epac , MR-GEF , Mras regulated guanine nucleotide exchange factor , guanine nucleotide exchange factor , SOS-2 , guanine nucleotide releasing factor , son of sevenless homolog 2

463284 Pan troglodytes
519566 Bos taurus
711698 Macaca mulatta
779207 Xenopus laevis
100067593 Equus caballus
100337732 Oryctolagus cuniculus
9771 Homo sapiens
217944 Mus musculus
362799 Rattus norvegicus
6655 Homo sapiens
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