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Browse our anti-GRB2 (GRB2) Antibodies

Full name:
anti-Growth Factor Receptor-Bound Protein 2 Antibodies (GRB2)
On www.antibodies-online.com are 155 Growth Factor Receptor-Bound Protein 2 (GRB2) Antibodies from 24 different suppliers available. Additionally we are shipping GRB2 Kits (36) and GRB2 Proteins (23) and many more products for this protein. A total of 223 GRB2 products are currently listed.
Synonyms:
AA408164, ASH, EGFRBP-GRB2, grb2, Grb3-3, MST084, MSTP084, NCKAP2, wu:fb18e12, wu:fb34e06, zgc:73077

Most Popular Reactivities for anti-GRB2 (GRB2) Antibodies

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anti-Mouse (Murine) GRB2 Antibodies:

anti-Rat (Rattus) GRB2 Antibodies:

anti-Human GRB2 Antibodies:

All available anti-GRB2 Antibodies

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Top referenced anti-GRB2 Antibodies

  1. Human Monoclonal GRB2 Primary Antibody for WB - ABIN2853618 : Rozakis-Adcock, Fernley, Wade, Pawson, Bowtell: The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. in Nature 1993 (PubMed)
    Show all 6 references for ABIN2853618

  2. Chicken Monoclonal GRB2 Primary Antibody for BI, IP - ABIN967754 : Elowe, Holland, Kulkarni, Pawson: Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction. in Molecular and cellular biology 2001 (PubMed)
    Show all 5 references for ABIN967754

  3. Human Polyclonal GRB2 Primary Antibody for IHC (p), WB - ABIN390236 : Kondo, Hirayama, Sugito, Shono, Tanaka, Kitamura: Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation. in The Journal of biological chemistry 2008 (PubMed)
    Show all 3 references for ABIN390236

  4. Human Polyclonal GRB2 Primary Antibody for EIA, IHC (p) - ABIN358793 : Morimatsu, Takagi, Ota, Iwamoto, Yanagida, Sako: Multiple-state reactions between the epidermal growth factor receptor and Grb2 as observed by using single-molecule analysis. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
    Show all 3 references for ABIN358793

  5. Human Polyclonal GRB2 Primary Antibody for EIA, IHC (p) - ABIN358795 : Martínez, García-Domínguez, Domingo, Oliva, Zarich, Sánchez, Gutiérrez-Eisman, Llopis, Rojas: Sprouty2 binds Grb2 at two different proline-rich regions, and the mechanism of ERK inhibition is independent of this interaction. in Cellular signalling 2007 (PubMed)
    Show all 3 references for ABIN358795

  6. Human Polyclonal GRB2 Primary Antibody for ELISA, WB - ABIN1534949 : Fath, Schweighoffer, Rey, Multon, Boiziau, Duchesne, Tocqué: Cloning of a Grb2 isoform with apoptotic properties. in Science (New York, N.Y.) 1994 (PubMed)
    Show all 2 references for ABIN1534949

  7. Human Polyclonal GRB2 Primary Antibody for IHC, ELISA - ABIN1532105 : Nishida, Yoshida, Itoh, Fukada, Ohtani, Shirogane, Atsumi, Takahashi-Tezuka, Ishihara, Hibi, Hirano: Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. in Blood 1999 (PubMed)
    Show all 2 references for ABIN1532105

  8. Cow (Bovine) Polyclonal GRB2 Primary Antibody for EIA, IHC (p) - ABIN782889 : Lowenstein, Daly, Batzer, Li, Margolis, Lammers, Ullrich, Skolnik, Bar-Sagi, Schlessinger: The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. in Cell 1992 (PubMed)

More Antibodies against GRB2 Interaction Partners

Mouse (Murine) Growth Factor Receptor-Bound Protein 2 (GRB2) interaction partners

  1. Grb2-deficient T cells show defects in T cell development, increased Th1 (show HAND1 Antibodies) and Th17 cell differentiation capacities, and impaired proliferation after activation by dendritic cells, which likely reduce the clinical symptoms of EAE.

  2. provide evidence that CD28 (show CD28 Antibodies) and the TCR complex regulate NF-kappaB (show NFKB1 Antibodies) via different signaling modules of GRB-2/VAV1 (show VAV1 Antibodies) and LAT (show LAT Antibodies)/ADAP (show APP Antibodies) pathways respectively.

  3. GRB2 physically links cyt (show CYGB Antibodies)-PTPe (show PTPRE Antibodies) with Src (show SRC Antibodies) and enables cyt (show CYGB Antibodies)-PTPe (show PTPRE Antibodies) to activate Src (show SRC Antibodies) downstream of activated integrins in osteoclast-like cells.

  4. SUMOylation of Grb2 enhances the ERK (show EPHB2 Antibodies) activity by increasing its binding with Sos1 (show SOS1 Antibodies).

  5. Data indicate that growth factor receptor (show RYK Antibodies) protein binding protein 2 (Grb2) is upregulated and regulated by Forkhead Box D3 (Foxd3 (show FOXD3 Antibodies)), and pregulated Grb2 interacts with huntingtin (Htt (show HTT Antibodies)).

  6. Grb2 contributes to immunoreceptor tyrosine-based activation motif signaling in platelets during hemostasis and thrombosis.

  7. Findings indicate Grb2 as a new FAK (show PTK2 Antibodies) activator and in coordinating PTPalpha (show PTPRA Antibodies) tyrosine phosphorylation to enable downstream integrin signaling and migration.

  8. Grb2 is not required for the establishment of the glomerular filtration barrier in vivo.

  9. Study shows that the ability of Sos1/Grb2 to appropriately regulate pluripotency and differentiation factors and to initiate primitive endoderm development requires collective binding of multiple Sos1/Grb2 domains to their protein and phospholipid ligands.

  10. findings suggest a novel role for GRB2 in ecotropic MLV entry and infection by facilitating mCAT-1 (show SLC7A1 Antibodies) trafficking

Human Growth Factor Receptor-Bound Protein 2 (GRB2) interaction partners

  1. TGF-beta2 (show TGFB2 Antibodies) induces Grb2 to recruit PI3-K (show PIK3CA Antibodies) to TGF-RII that activates JNK (show MAPK8 Antibodies)/AP-1 (show FOSB Antibodies)-signaling and augments invasiveness of Theileria-transformed macrophages.

  2. Genetic variation near GRB2 on chromosome 17q25.1 is associated with sight-threatening diabetic retinopathy.

  3. Only monomeric Grb2 is capable of upregulating MAP kinase (show MAPK1 Antibodies) signalling. The dimeric state is inhibitory to this process. The self-association/dissociation of Grb2 represents a switch that regulates MAP kinase (show MAPK1 Antibodies) activity and hence controls cancer progression.

  4. The immunoglobulin tail tyrosine motif in the cytoplasmic segments of membrane-bound IgGs acts as the principle signal amplifier by incorporating a Grb2-Btk (show BTK Antibodies) signaling.

  5. findings show that regions outside of the consensus PxxPxR sites drive the high affinity association of GRB2 with SH3 domain (show ITSN1 Antibodies) ligands

  6. down-regulated molecule growth factor receptor-bound protein 2 (GRB2) was a prominent node in fourteen cell proliferation-related sub-pathways.

  7. C-SH3 of Grb2 mediates the interaction with mutant Htt (show HTT Antibodies) and this interaction being stronger could replace Gab1 (show GAB1 Antibodies), with mutant Htt (show HTT Antibodies) becoming the preferred partner. This would have immense effect on downstream signaling events.

  8. GRB2 was an independent factor in prognosis of esophageal squamous cell carcinoma patients

  9. In addition, GRB2 and UBC (show RPS27A Antibodies) were found to be hub nodes in the differentially expressed subnetwork and may be used as potential biomarkers or targets for the diagnosis of bladder cancer.

  10. The N-terminal SH3 domain (show ITSN1 Antibodies) of Grb2 specifically interacts with UVRAG (show UVRAG Antibodies), unlike the C-terminal SH3 domain (show ITSN1 Antibodies). This interaction helps to understand the role of Grb2 in the autophagic maturation of vesicles.

Pig (Porcine) Growth Factor Receptor-Bound Protein 2 (GRB2) interaction partners

  1. in VSMCs exposed to hyperglycemia, IGF-I (show IGF1 Antibodies) stimulation of Shc (show SHC1 Antibodies) facilitates the transfer of Grb2 to p85 (show ARHGEF7 Antibodies) resulting in enhanced PI3K activation and AKT (show AKT1 Antibodies) phosphorylation leading to enhanced cell proliferation and migration

GRB2 Antigen Profile

Antigen Summary

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with GRB2

  • growth factor receptor-bound protein 2 (GRB2) antibody
  • Growth factor receptor-bound protein 2 (grb2) antibody
  • growth factor receptor-bound protein 2 (grb2) antibody
  • growth factor receptor bound protein 2 (Grb2) antibody
  • growth factor receptor-bound protein 2 (LOC100342500) antibody
  • growth factor receptor-bound protein 2 (Grb2) antibody
  • growth factor receptor-bound protein 2b (grb2b) antibody
  • AA408164 antibody
  • ASH antibody
  • EGFRBP-GRB2 antibody
  • grb2 antibody
  • Grb3-3 antibody
  • MST084 antibody
  • MSTP084 antibody
  • NCKAP2 antibody
  • wu:fb18e12 antibody
  • wu:fb34e06 antibody
  • zgc:73077 antibody

Protein level used designations for GRB2

growth factor receptor-bound protein 2 , Growth factor receptor-bound protein 2 , SH2/SH3 adapter GRB2 , adapter protein GRB2 , protein Ash , HT027 , abundant SRC homology , epidermal growth factor receptor-binding protein GRB2 , growth factor receptor-bound protein 3 , growth factor receptor bound protein 2 , fb18e12

GENE ID SPECIES
737245 Pan troglodytes
100306767 Salmo salar
100528114 Ictalurus punctatus
14784 Mus musculus
81504 Rattus norvegicus
2885 Homo sapiens
483312 Canis lupus familiaris
535298 Bos taurus
100342500 Oryctolagus cuniculus
100715453 Cavia porcellus
100192436 Sus scrofa
386572 Gallus gallus
101109893 Ovis aries
100173972 Pongo abelii
406308 Danio rerio
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